The Respiratory Burst and Its Physiological Significance

1. Front Matter

   Pages i-xxiii

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2. The Respiratory Burst

   • Niels Borregaard

   Pages 1-31

3. The Respiratory Burst of Phagocytes

   • Giorgio Berton, Stefano Dusi, Paolo Bellavite

   Pages 33-52

4. The Respiratory Burst and the NADPH Oxidase of Phagocytic Leukocytes

   • Dirk Roos, René Lutter, Ben G. J. M. Bolscher

   Pages 53-76

5. The Respiratory Burst and Cellular Ion Homeostasis

   • Barbara Styrt, Mark S. Klempner

   Pages 77-98

6. An Expanded View of the Phagocytic Respiratory Burst

   • Myron S. Cohen, Bradley E. Britigan

   Pages 99-116

7. The Respiratory Burst and Endothelial Cells

   • Aldo Dobrina, Pierluigi Patriarca

   Pages 117-140

8. The Respiratory Burst of Eosinophils

   • Giuliano Zabucchi, Renzo Menegazzi, Pierluigi Patriarca

   Pages 141-157

9. The Respiratory Burst and Lymphocyte Function

   • Arthur L. Sagone Jr.

   Pages 159-190

10. Modulation of the Respiratory Burst by Naturally Occurring Substances

    • Stanley D. Somerfield, Emil Skamene

    Pages 191-201

11. Oxidants Formed by the Respiratory Burst

    • Peter J. O’Brien

    Pages 203-232

12. Drug-Induced Agranulocytosis and Other Effects Mediated by Peroxidases during the Respiratory Burst

    • Jack P. Uetrecht

    Pages 233-243

13. The Respiratory Burst and the Metabolism of Drugs

    • Arthur L. Sagone Jr.

    Pages 245-276

14. The Respiratory Burst and Carcinogenesis

    • Leo I. Gordon, Sigmund A. Weitzman

    Pages 277-298

15. The Respiratory Burst and Mechanisms of Oxygen Radical-Mediated Tissue Injury

    • Jeffrey S. Warren, Peter A. Ward, Kent J. Johnson

    Pages 299-314

16. The Respiratory Burst of Neutrophilic Granulocytes and Its Influence on Infected Tissues

    • Jan Maciej Zgliczyński, Teresa Stelmaszyńska

    Pages 315-347

17. The Respiratory Burst and Psoriasis

    • Rudolf E. Schopf

    Pages 349-371

18. The Respiratory Burst and Diabetes Mellitus

    • József T. Nagy, Tamás Fülöp Jr., George Paragh, Gabriella Fóris

    Pages 373-383

19. The Respiratory Burst of Fertilization

    • Eric E. Turner, Bennett M. Shapiro

    Pages 385-403

20. The Respiratory Burst and Atherosclerosis

    • George Paragh, Éva M. Kovács, József T. Nagy, Gabriella Foŕis, Tamás Fülöp Jr.

    Pages 405-418

When phagocytes are exposed to a number of different stimuli, they undergo dra­ matic changes in the way they process oxygen. Oxygen uptake increases markedly, frequently more than 50-fold; the phagocytes begin to produce large quantities of superoxide and hydrogen peroxide; and they immediately begin to metabolize large amounts of glucose by way of the hexose monophosphate shunt. This series of changes has become known as the respiratory burst. It was first believed that the major function of this respiratory burst was to generate powerful antibacterial agents by the partial reduction of oxygen. It is becoming apparent that the respiratory burst has much wider application, and its physiological function in many different biolog­ ical areas is clear. In this volume, we have attempted to bring together the work of experts who have published extensively on the involvement of the respiratory burst in different physiological functions. In the first three chapters, Dr. Borregaard and Dr. Berton and co-workers and Dr. Roos and co-workers bring together what is known about the respiratory burst. They present up-to-date versions of the biochemical and metabolic activities associ­ ated with the burst. In Chapter 4, Dr. Styrt and Dr. Klempner discuss the respiratory burst as it affects cellular ion homeostasis. Dr. Cohen and Dr. Britigan (Chapter 5) present some interesting data on the competition between the respiratory burst and bacteria for oxygen. Dr. Dobrina and Dr.

• Calcium
• DNA
• EPO
• Fructose
• Nucleotide
• Oxidation
• bacteria
• development
• enzymes
• growth
• homeostasis
• metabolism
• microorganism
• pharmacology
• protein

• St. Margaret’s Hospital for Women, Boston, USA

  Anthony J. Sbarra

• Tufts University School of Medicine, Boston, USA

  Anthony J. Sbarra

• Clinical Pathology Facility, Inc., Pittsburgh, USA

  Robert R. Strauss

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