Skip to main content
SpringerLink
Log in

Cellular and Molecular Aspects of Inflammation

  • Book
  • © 1988

Overview

Editors:
  1. George Poste

    1. Department of Molecular Pharmacology, Smith Kline & French Laboratories, Philadelphia, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Stanley T. Crooke

    1. Department of Molecular Pharmacology, Smith Kline & French Laboratories, Philadelphia, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: New Horizons in Therapeutics (NHTH)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (23 chapters)

  1. Front Matter

    Pages i-xxv
    Download chapter PDF

  2. Cellular Interactions in Inflammatory Processes

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Cellular Interactions Regulating Inflammation

      • T. D. Geppert, P. E. Lipsky
      Pages 3-29

    3. Triggering and Activation of Human Neutrophils

      • Kathleen A. Haines, Joan Reibman, Gerald Weissmann
      Pages 31-40

    4. Neutrophil Emigration

      • Myron I. Cybulsky, M. K. William Chan, Henry Z. Movat
      Pages 41-56

    5. The Role of Endothelium in Chronic Inflammation

      • Morris Ziff, Druie Cavender
      Pages 57-64

  3. Peptide Mediators of Inflammation

    1. Front Matter

      Pages 65-65
      Download chapter PDF

    2. Peptide Mediators of Inflammation

      • Stephen M. Krane
      Pages 67-73

    3. Interleukin-1

      • Steven B. Mizel
      Pages 75-95

    4. Structure—Function Relations for the Interleukin-2 Receptor

      • Richard J. Robb
      Pages 97-122

    5. Cachectin (Tumor Necrosis Factor)

      • Kirk R. Manogue, Anthony Cerami
      Pages 123-150

  4. Biosynthesis and Release of Lipid Mediators of Inflammation

    1. Front Matter

      Pages 151-151
      Download chapter PDF

    2. Arachidonic Acid Metabolism in Tissue Injury

      • Stephen M. Spaethe, Philip Needleman
      Pages 153-169

    3. Lipoxygenase Metabolites

      • Joshua Rokach, Brian J. Fitzsimmons
      Pages 171-206

  5. Molecular Intermediates in Signal Transductions

    1. Front Matter

      Pages 207-207
      Download chapter PDF

    2. Guanine Nucleotide Regulatory Proteins in Inflammatory and Immune Responses

      • Allen M. Spiegel
      Pages 209-227

    3. Regulation of Phosphoinositide Breakdown

      • John H. Exton
      Pages 229-263

    4. Regulation of Protein Kinase C by Sphingosine/Lysosphingolipids

      • Robert M. Bell, Carson R. Loomis, Yusuf A. Hannun
      Pages 265-286

    5. Regulation of Inositol Trisphosphate Formation and Action

      • James W. Putney Jr.
      Pages 287-302

  6. Receptors and Signal Transduction Processes Involved in Inflammation

    1. Front Matter

      Pages 303-303
      Download chapter PDF
Back to top

Keywords

About this book

The characterization of the cellular and molecular mechanisms that mediate inflammation provides a foundation that supports future studies that will de­ fine mechanisms more intimately. It encourages substantial optimism about the opportunities to understand the inflammatory process and to use that information to develop novel therapeutic approaches. Recent progress has defined the cells that mediate the inflammatory response, many of the inter­ cellular transmitters, the receptors, signal transduction processes and regula­ tory mechanisms. Thus, we now have the opportunity to understand inflammation in pharmacologic terms and to attack the key molecular targets to develop new therapeutics. Among the cells involved in the inflammatory response are the lympho­ cytes, neutrophils and endothelial cells. Maintenance of homeostasis, re­ sponse to proinflammatory stimuli and pathophysiologic responses are products of complex interactions between these and other elements of the immune systems. Each of these cells displays a variety of receptors to define the stimuli to which they respond. The receptors displayed that the signal transduction processes and cellular responses are regulated genetically and epigenetic ally . The critical role of membranes and particularly the phospho­ lipid components of the membranes is emphasized by recent studies.

Editors and Affiliations

  • Department of Molecular Pharmacology, Smith Kline & French Laboratories, Philadelphia, USA

    George Poste, Stanley T. Crooke

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation