Cellular and Molecular Aspects of Inflammation

1. Front Matter

   Pages i-xxv

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2. Cellular Interactions in Inflammatory Processes

   1. Front Matter

      Pages 1-1

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   2. Cellular Interactions Regulating Inflammation

      • T. D. Geppert, P. E. Lipsky

      Pages 3-29

   3. Triggering and Activation of Human Neutrophils

      • Kathleen A. Haines, Joan Reibman, Gerald Weissmann

      Pages 31-40

   4. Neutrophil Emigration

      • Myron I. Cybulsky, M. K. William Chan, Henry Z. Movat

      Pages 41-56

   5. The Role of Endothelium in Chronic Inflammation

      • Morris Ziff, Druie Cavender

      Pages 57-64

3. Peptide Mediators of Inflammation

   1. Front Matter

      Pages 65-65

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   2. Peptide Mediators of Inflammation

      • Stephen M. Krane

      Pages 67-73

   3. Interleukin-1

      • Steven B. Mizel

      Pages 75-95

   4. Structure—Function Relations for the Interleukin-2 Receptor

      • Richard J. Robb

      Pages 97-122

   5. Cachectin (Tumor Necrosis Factor)

      • Kirk R. Manogue, Anthony Cerami

      Pages 123-150

4. Biosynthesis and Release of Lipid Mediators of Inflammation

   1. Front Matter

      Pages 151-151

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   2. Arachidonic Acid Metabolism in Tissue Injury

      • Stephen M. Spaethe, Philip Needleman

      Pages 153-169

   3. Lipoxygenase Metabolites

      • Joshua Rokach, Brian J. Fitzsimmons

      Pages 171-206

5. Molecular Intermediates in Signal Transductions

   1. Front Matter

      Pages 207-207

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   2. Guanine Nucleotide Regulatory Proteins in Inflammatory and Immune Responses

      • Allen M. Spiegel

      Pages 209-227

   3. Regulation of Phosphoinositide Breakdown

      • John H. Exton

      Pages 229-263

   4. Regulation of Protein Kinase C by Sphingosine/Lysosphingolipids

      • Robert M. Bell, Carson R. Loomis, Yusuf A. Hannun

      Pages 265-286

   5. Regulation of Inositol Trisphosphate Formation and Action

      • James W. Putney Jr.

      Pages 287-302

6. Receptors and Signal Transduction Processes Involved in Inflammation

   1. Front Matter

      Pages 303-303

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The characterization of the cellular and molecular mechanisms that mediate inflammation provides a foundation that supports future studies that will de­ fine mechanisms more intimately. It encourages substantial optimism about the opportunities to understand the inflammatory process and to use that information to develop novel therapeutic approaches. Recent progress has defined the cells that mediate the inflammatory response, many of the inter­ cellular transmitters, the receptors, signal transduction processes and regula­ tory mechanisms. Thus, we now have the opportunity to understand inflammation in pharmacologic terms and to attack the key molecular targets to develop new therapeutics. Among the cells involved in the inflammatory response are the lympho­ cytes, neutrophils and endothelial cells. Maintenance of homeostasis, re­ sponse to proinflammatory stimuli and pathophysiologic responses are products of complex interactions between these and other elements of the immune systems. Each of these cells displays a variety of receptors to define the stimuli to which they respond. The receptors displayed that the signal transduction processes and cellular responses are regulated genetically and epigenetic ally . The critical role of membranes and particularly the phospho­ lipid components of the membranes is emphasized by recent studies.

• Lipid
• immune system
• inflammation
• molecular aspects
• receptor

• Department of Molecular Pharmacology, Smith Kline & French Laboratories, Philadelphia, USA

  George Poste, Stanley T. Crooke

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