Immunobiology of Proteins and Peptides IV

1. Front Matter

   Pages i-xi

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2. The Major Histocompatibility Complex and Protein Recognition by T Lymphocytes

   • Jan Klein

   Pages 1-10

3. Murine Ia Genes: Organization, Polymorphism and Heterogeneity

   • Kathleen Donovan, Chella S. David

   Pages 11-35

4. Intermediates in Class II HLA Antigen Biosynthesis

   • Peter Cresswell, Drew N. Kelner, Michael S. Marks

   Pages 37-42

5. Trinitrophenyl Reactive T-Cell Clones in Functional and Molecular Analysis of the HLA-D Region

   • Robert R. Rich, Jeffrey H. Hanke, Richard G. Cook

   Pages 43-54

6. T-Cells Recognize IA Conformation in the Interaction with Antigen Presenting Cells

   • Harley Y. Tse, Ted H. Hansen, Shirley C-C. Lin, Alan S. Rosenthal

   Pages 55-63

7. T-Cell Recognition and Antigen Presentaion of Myoglobin

   • M. Z. Atassi, Garvin S. Bixler Jr.

   Pages 65-87

8. T-Cell Recognition and Antigen Presentation of Lysozyme

   • Garvin S. Bixler Jr., M. Zouhair Atassi

   Pages 89-101

9. The Regions of T-cell Recognition on the Extracellular Part of the α Chain of Torpedo Californica Acetylcholine Receptor

   • Tsuyoshi Yokoi, Biserka Mulac-Jericevic, M. Zouhair Atassi

   Pages 103-113

10. Structural Considerations of T-Cell Cognizance of Antigen

    • Eli Benjamini, Beatrice C. Langton, Carl E. Mackewicz

    Pages 115-127

11. Antigen Presenting Cells: Detection and Quantification of a Cytochrome c Determinant Important for Activation of T-Cells on Bone Marrow Derived Macrophages by using Specific Anti Cytochrome c Monoclonal Antibody

    • Stéphane Demotz, Claudio Vita, Giampietro Corradin

    Pages 129-145

12. Antigen Processing and Presentation at a Molecular Level

    • Paul M. Allen, Emil R. Unanue

    Pages 147-154

13. The Role of Surface Immunoglobulin in the Processing and Presentation of Antigen

    • Lisa A. Casten, Susan K. Pierce

    Pages 155-159

14. A Peptide Binding Protein Which Plays a Role in Antigen Presentation

    • E. K. Lakey, J. A. Smith, E. Margoliash, S. K. Pierce

    Pages 161-164

15. T-Cell Clones Specific for Synthetic Polypeptides in Cellular Collaborations

    • Edna Mozes, Heidy Zinger, Ofra Axelrod

    Pages 165-181

16. Modulation of T-Cell Functions by Peptide Hormones

    • Christopher J. Krco, Tu T. Nguyen, Vay Liang W. Go

    Pages 183-188

17. Endosome Acidification and the Pathways of Receptor-Mediated Endocytosis

    • Frederick R. Maxfield, Darrell J. Yamashiro

    Pages 189-198

18. Intracellular Traffic of the Mannose 6-Phosphate Receptor and Its Ligands

    • Catherine M. Nolan, William S. Sly

    Pages 199-212

19. Use of Synthetic Peptides in the Delineation of the Role of Non-Antigen Receptors in Mast Cell Signalling Processes

    • D. R. Stanworth

    Pages 213-222

20. Structure and Expression of Genes Involved in T Lymphocyte Recognition and Activation

    • M. J. Owen, M. J. Crumpton, J. Dunne, G. Krissansen, J. Lamb, W. Sewell

    Pages 223-231

This symposium was established in 1976 for the purpose of bringing to­ gether once every two or three years, active investigators in the fore­ front of contemporary immunology, to present their findings and to discuss their significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the under­ standing of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptides which should have enormous potential in biological, therapeutic and basic applications. This anticipated explosion has finally occurred and many applications of these peptides are now being realized. The main symposia topics of the fourth symposium were: T-cell recognition of proteins, structure and function of the T-cell receptor, presentation of protein antigens, recycling and activation of membrane receptor molecules, Ir-gene control of T-cell responses and methods of cell separation. The molecular features recognized by antibodies on proteins were the first immune recognition sites to be local ized and confirmed by synthetic peptides. The complete antigenic structures of several proteins have been defined, and individual antigenic sites have been described on many more proteins. More recently, major breakthroughs have been reported in the immune recognition of proteins by T cells.

• antibody
• antigen
• immunobiology
• immunology
• proteins

• Baylor College of Medicine, Houston, USA

  M. Zouhair Atassi

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