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Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System

  • Book
  • © 1987

Overview

Editors:
  1. Mohan K. Raizada

    1. University of Florida, Gainesville, USA

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  2. M. Ian Phillips

    1. University of Florida, Gainesville, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Derek LeRoith

    1. Diabetes Branch, NIDDK, NIH, Bethesda, USA

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-viii
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  2. Insulin Receptors: Structure and Function

    1. Internalization of Insulin and Its Receptor: Role in Signaling

      • Barry I. Posner, Masood N. Khan, John J. M. Bergeron
      Pages 1-10

    2. Insulin-Activated Phosphorylation on Tyrosine of a 15 Kilodalton Cytosolic Protein in 3T3-L1 Adipocytes

      • Michel Bernier, Susan C. Frost, Don M. Laird, Ronald A. Kohanski, M. Daniel Lane
      Pages 11-26

    3. Role of Protein Phosphorylation in Growth Factor Signal Transduction

      • S. L. Pelech, D. A. Tinker, C. P. Chan, E. G. Krebs
      Pages 27-46

    4. The Processing and Transport of Peptide Hormones Across Endothelial Cell Barriers

      • Donald P. Bottaro, George L. King
      Pages 47-60

    5. The Role of Phospholipid Metabolism in Insulin Action

      • Robert V. Farese, Denise R. Cooper
      Pages 61-69

    6. Glucose Transporters: Overview and Implications for the Brain

      • Eddy Karnieli, W. Timothy Garvey
      Pages 71-92

    7. Alteration of Insulin Receptor Binding and Protein Kinase Activity in Rat Liver and Placenta by ß-Naphthoflavone

      • Shoou-Lih Wang, Mohan K. Raizada, Kathleen T. Shiverick
      Pages 93-106

  3. Insulin and Insulin Receptors in the Central Nervous System

    1. Evolution of Insulin and Insulin Receptors

      • Derek LeRoith, William L. Lowe Jr., Charles T. Roberts Jr.
      Pages 107-120

    2. Evidence for Central Nervous System Insulin Synthesis

      • Derrel W. Clarke, Jennifer J. Poulakos, Laura M. Mudd, Mohan K. Raizada, David L. Cooper
      Pages 121-130

    3. Localization of Insulin to Neuronal Cells

      • Sherin Devaskar, Ruben Schechter, Arnold Kahn
      Pages 131-137

    4. Synthesis of Insulin or a Similar Peptide in the Pituitary Gland and in Retinal Muller Cells

      • G. Colin Budd, Ben Pansky
      Pages 139-149

    5. Insulin in the Central Nervous System: A Regulator of Appetite and Body Weight

      • Dianne P. Figlewicz, Stephen C. Woods, Denis G. Baskin, Daniel M. Dorsa, Barbara J. Wilcox, Leslie J. Stein et al.
      Pages 151-162

    6. Insulin in the Brain: A Feedback Loop Involving Brain Insulin and Circumventricular Organs

      • M. Ian Phillips
      Pages 163-175

    7. Structural Evidence for a Subtype of Insulin Receptor in the Central Nervous System

      • Kim A. Heidenreich
      Pages 177-190

    8. Physiologically Unique Insulin Receptors on Neuronal Cells

      • Mohan K. Raizada, Frederick T. Boyd, Derrel W. Clarke, Derek Le Roith
      Pages 191-200

    9. Insulin Receptors in Brain Development

      • William A. Brennan Jr.
      Pages 201-208

    10. Insulin Downregulates Alpha-2 Adrenergic Receptors in Cultured Glial Cells

      • Elaine M. Richards, Mohan K. Raizada, Colin Sumners
      Pages 209-214

  4. Insulin-Like Growth Factor and Insulin-Like Growth Factor Receptors in the Central Nervous System

    1. Somatomedins (Insulin-Like Growth Factors) and the Nervous System

      • Yutaka Oomura, Carlos R. Plata-Salamán
      Pages 215-244

    2. Insulin-Like Growth Factor Receptors in the Brain

      • Denis G. Baskin, Nancy J. Bohannon, Dianne P. Figlewicz
      Pages 245-260
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Keywords

About this book

Traditionally, intercellular communication and the regulation of biological functions of the body have been considered the role of two major and distinct systems: the nervous system and the endocrine system. The classic nervous system transmitted its signal rapidly by using electrical currents, whereas the signals used by the endocrine system were hormones produced by endocrine glands which reached the target tissues via the blood stream. During the past few decades, it has become apparent that these systems of intercellular com­ munication are not distinct and the signal messenger molecules are not unique to one or the other system. Many classic endocrine hormones are found in and act on nervous tissues and evidence exists for their de novo synthesis by neural­ related tissues. An exciting development in this area is the possibility that insulin and insulin-like growth factors (IGF) are not only produced by neural tissues but also exert profound physiological and biochemical effects on these tissues. The area of investigation of CNS insulin and IGF has been expanding rapidly and the availability of this book complete with up-to-date reviews on the subject by leaders in the field allows other scientists to utilize the knowledge in planning and adapting the latest ideas for future experiments. In addition, the book provides a collection of up-to-date articles for teachers to be used for the latest instructional material. The first section of the book covers general aspects of insulin receptors and insulin action.

Editors and Affiliations

  • University of Florida, Gainesville, USA

    Mohan K. Raizada, M. Ian Phillips

  • Diabetes Branch, NIDDK, NIH, Bethesda, USA

    Derek LeRoith

Bibliographic Information

  • Book Title: Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System

  • Editors: Mohan K. Raizada, M. Ian Phillips, Derek LeRoith

  • DOI: https://doi.org/10.1007/978-1-4684-5380-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1987

  • Softcover ISBN: 978-1-4684-5382-9Published: 19 March 2012

  • eBook ISBN: 978-1-4684-5380-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 358

  • Topics: Tree Biology

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