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Mechanisms of Lymphocyte Activation and Immune Regulation

  • Book
  • © 1987

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Editors:
  1. Sudhir Gupta

    1. University of California, Irvine, USA

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  2. William E. Paul

    1. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

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  3. Anthony S. Fauci

    1. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 213)

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. T Cell Receptor

    1. The T Cell Receptor: Its Repertoire and Role in Thymocyte Development

      • Philippa Marrack, Marcia McDuffie, Willi Born, Marica Blackman, Charles Hannum, John Kappler
      Pages 1-12

    2. Murine T-Cell Receptor Genes

      • M. M. Davis, N. R. J. Gascoigne, T. Lindsten, C. Goodnow, Y. Chien
      Pages 13-17

    3. Correspondence Between Functionally Significant Sequences in Immunoglobulin and the T Cell Receptor for Antigen

      • Stephen M. Hedrick, Isaac Engel, Pamela J. Fink
      Pages 19-27

  3. T Cell Activation

    1. The Early Mitogenic Pathway in Mouse Thymocytes: An Analysis of the Dual Signal Hypothesis

      • James C. Metcalfe, Gerry A. Smith, John P. Moore, Robin Hesketh
      Pages 29-44

    2. The Role of the Antigen Receptor/T3 Complex in T-Cell Activation

      • Arthur Weiss, John Imboden, Ken Hardy, John Stobo
      Pages 45-49

    3. Early Events in Lymphocyte Activation Triggered Via CD3/Ti or CD2

      • P. C. L. Beverley, D. L. Wallace, K. O’Flynn, D. C. Linch
      Pages 51-58

    4. Human T Lymphocyte Activation

      • Claudio Milanese, Robert F. Siliciano, Neil E. Richardson, Hsiu-Ching Chang, Andres Alcover, Ellis L. Reinherz
      Pages 59-68

    5. Transmembrane Signals in the Activation of T Lymphocytes

      • John W. Hadden
      Pages 69-83

    6. Ion Channels in T Lymphocytes

      • Michael D. Cahalan, K. George Chandy, Thomas E. DeCoursey, Sudhir Gupta, Richard S. Lewis, Jeffrey B. Sutro
      Pages 85-101

  4. Interleukins and Their Receptors

    1. The Multiple Biological Properties of Interleukin-1 Influencing Immunocompetent Cells

      • Charles A. Dinarello
      Pages 103-114

    2. Autocrine Growth Function of Interleukin-1-Like Molecules Secreted by Neoplastic Human B Cells

      • G. Scala, F. Ferrara, T. Pastore, F. Alfinito, R. Pizzano, L. Corbo et al.
      Pages 115-124

    3. Dissection of the Molecular Events Occurring During T Cell Cycle Progression

      • Kendall A. Smith
      Pages 125-128

    4. The Interleukin-2 Receptor on Normal and Malignant Lymphocytes

      • Thomas A. Waldmann
      Pages 129-137

    5. IL-2 Receptor Gene Activation by ATL-Derived Factor (ADF)

      • Junji Yodoi, Masafumi Okada, Yutaka Tagaya, Yoshihisa Taniguchi, Keisuke Teshigawara, Tadashi Kasahara et al.
      Pages 139-148

    6. Mechanisms in Interleukin 3 Regulated Growth and Differentiation

      • James N. Ihle, Yacob Weinstein, Ulf R. Rapp, John L. Cleveland, E. Premkumar Reddy
      Pages 149-162

  5. B Lymphocyte Activation, Proliferation and Differentiation

    1. The Activation, Proliferation, and Differentiation of Human B Lymphocytes

      • Julian L. Ambrus Jr., Cynthia H. Jurgensen, Debra L. Bowen, Shohken Tomita, Toshimasa Nakagawa, Naoko Nakagawa et al.
      Pages 163-175

    2. Delineation of Human B Cell Differentiation: Immunological and Molecular Characterization of Human B Cell Differentiation Factor (BSF-2)

      • Tadamitsu Kishimoto, Toshio Hirano, Hitoshi Kikutani, Atsushi Muraguchi
      Pages 177-188

    3. Transmembrane Signaling Reactions Generated in B Cells in Response to ANTI-IgM or Lipopolysaccharide

      • Anthony L. DeFranco
      Pages 189-193

    4. Coupling of B Cell Surface Ig, Ia and BSF1 Receptors to Intracellular “Second Messengers”

      • J. C. Cambier, J. T. Ransom, L. K. Harris, K. M. Coggeshall, Z. Z. Chen, M. K. Newell et al.
      Pages 195-205
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Keywords

About this book

During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.

Editors and Affiliations

  • University of California, Irvine, USA

    Sudhir Gupta

  • National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

    William E. Paul, Anthony S. Fauci

Bibliographic Information

  • Book Title: Mechanisms of Lymphocyte Activation and Immune Regulation

  • Editors: Sudhir Gupta, William E. Paul, Anthony S. Fauci

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5323-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1987

  • Softcover ISBN: 978-1-4684-5325-6Published: 27 December 2012

  • eBook ISBN: 978-1-4684-5323-2Published: 11 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: IX, 337

  • Topics: Classical Mechanics, Cell Biology

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