Overview
- Editors:
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Illani Atwater
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National Institutes of Health, Bethesda, USA
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Eduardo Rojas
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National Institutes of Health, Bethesda, USA
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Bernat Soria
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University of Alicante, Alicante, Spain
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Table of contents (46 chapters)
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New Experimental Approaches
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- E. Rojas, E. Forsberg, H. B. Pollard
Pages 7-29
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- E. Perez-Armendariz, I. Atwater
Pages 31-51
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K-Channels
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- F. M. Ashcroft, D. E. Harrison, S. J. H. Ashcroft
Pages 53-62
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- D. L. Cook, C. N. Hales, L. S. Satin
Pages 63-67
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- M. L. J. Ashford, N. C. Sturgess, D. L. Cook, C. N. Hales
Pages 69-76
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- O. H. Petersen, I. Findlay, M. J. Dunne
Pages 77-82
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- J. C. Henquin, M. G. Garrino, M. Nenquin, G. Paolisso, M. Hermans
Pages 83-93
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- R. M. Santos, H. Finol, E. Rojas
Pages 109-123
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- J. Lopez-Barneo, L. Tabares, A. Castellano
Pages 125-137
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Ca-Channels
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- A. G. Garcia, C. R. Artalejo, R. Borges, J. A. Reig, F. Sala
Pages 139-157
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- M. Vasseur, A. Debuyser, M. Joffre
Pages 195-200
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- F. Malaisse-Lagae, A. Sener, W. J. Malaisse
Pages 201-205
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Role of Ionic Channels
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- P. C. Croghan, C. M. Dawson, A. M. Scott, J. A. Bangham
Pages 207-223
About this book
Pancreatic a-cell biophysics has undergone a veritable informa tion explosion in the past two years. Single channel and macroscopic currents have become easily accessible following the introduction of the patch clamp technique. In addition to this new approach, further development of techniques for optical measurements, ion-sensitive microelectrodes, permeabilized cells and mathematical modelling have recently added to the now classical techniques of membrane potential recording and tracer flux measurement. The International Workshop on Biophysics of the Pancreatic a-Cell held in Alicante (Spain) on Sep tember 30 - October 1, 1985, has now given us the opportunity to share experiences with these new techniques applied to the a-cell. Further more this was the first occasion for most of the groups doing patch clamp studies of the a-cell to decide on appropriate nomenclature and to debate the different characteristics of the a-cell ionic channels. To make this information available to the larger scientific community a record of the meeting has been assembled in this book. It is a collection of research papers by leading scientists at the meet ing working on biophysical, biochemical and physiological aspects. of secretion. We grouped their contributions in seven sections, includ ing new experimental approaches, K-channels, Ca-channels, role of ionic channels, intracellular ionized calcium, neural regulation and mechanisms of insulin release. Each section gives an account of the state of the problem at the time of the meeting, and the subjects are analyzed from the different perspectives of the various contributors.
