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New Experimental Modalities in the Control of Neoplasia

  • Book
  • © 1986

Overview

Editors:
  1. Prakash Chandra

    1. University of Frankfurt, Frankfurt am Main, Federal Republic of Germany

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Part of the book series: NATO Science Series A: (NSSA, volume 120)

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. A Developmental Biologist’s View on Cancer

    • Francois Gros, Marc Fiszman, Didier Montarras
    Pages 1-13

  3. Oncogenes in Development, Neoplasia, and Evolution

    • Fritz Anders, Annerose Anders, Manfred Schartl, Thomas Gronau, Wolfgang Lüke, Carl-Rudolf Schmidt et al.
    Pages 15-40

  4. Acquisition of Metastatic Properties via Somatic Cell Fusion: Implications for Tumor Progression in Vivo

    • Patrick De Baetselier, Ed Roos, Hendrik Verschueren, Steven Verhaegen, Daniel Dekegel, Lea Brys et al.
    Pages 41-55

  5. Oncogenes and Tyrosine Kinase Activities as a Function of the Metastatic Phenotype

    • Lea Eisenbach, Michael Feldman
    Pages 57-70

  6. Immune Reactivities During the Precancer and Early Cancer Periods: Novel Approaches for Immunomodulation

    • Isaac P. Witz, Liora Agassy-Cahalon, Benjamin Fish, Yaron Lidor, Yardena Ovadia, Haim Pinkas et al.
    Pages 71-80

  7. Immunomodulation of Tumor Metastases

    • L. Eisenbach, S. Katzav, M. Feldman
    Pages 81-90

  8. Monoclonal Antibody Targeting of Anti-Cancer Agents

    • R. W. Baldwin
    Pages 91-99

  9. Treatment of Human B Cell Lymphoma with Monoclonal Anti-Idiotype Antibodies

    • E. M. Rankin, A. Hekman
    Pages 101-122

  10. Human Monoclonal Antibodies Directed Against HuMTV Antigens from Human Breast Cancer Cells

    • I. Keydar, I. Tsarfaty, N. Smorodinsky, E. Sahar, Y. Shoenfeld, S. Chaitchik
    Pages 123-135

  11. Recent Advances in Thymic Hormone Research

    • Marcelo B. Sztein, Allan L. Goldstein
    Pages 137-164

  12. T-Cell Growth Factor (Interleukin-2)

    • Suresh K. Arya, M. G. Sarngadharan
    Pages 165-182

  13. Drug Resistance: New Approaches to Treatment

    • J. R. Bertino, S. Srimatkandada, M. D. Carman, M. Jastreboff, L. Mehlman, W. D. Medina et al.
    Pages 183-193

  14. Mechanisms of Membrane-Mediated Cytotoxicity by Adriamycin

    • Thomas Grace, Yigal H. Ehrlich, Thomas R. Tritton
    Pages 195-202

  15. Terminal Transferase and Adenosine Deaminase Activities in Human Neoplasia: Their Role in Modulating Cancer Treatment

    • P. S. Sarin, A. Thornton, D. Sun
    Pages 203-212

  16. Inhibitors of Terminal Transferase: A New Strategy for the Treatment of Human Leukemia

    • Ronald McCaffrey, Amy Ahrens, Richard Bell, Robert Duff, Henry Hoppe, Anne Lillquist et al.
    Pages 213-221

  17. DNA-Protein Crosslinking of Platinum Coordination Complex in Living Cells: Implication to Evaluate the Cytotoxic Effects of Chemotherapeutic Agents

    • L. S. Hnilica, R. Olinski, Z. M. Banjar, W. N. Schmidt, R. C. Briggs
    Pages 223-233

  18. Antitumor Activity, Pharmacology and Clinical Trials of Elliptinium (NSC 264-137)

    • Anette Kragh Larsen, Claude Paoletti
    Pages 235-241

  19. Therapeutic Efficacy of Oxazaphosphorines by Immunomodulation

    • R. Voegeli, J. Pohl, T. Reissmann, J. Stekar, P. Hilgard
    Pages 243-247

  20. The Role of Cellular Glutathione in Protecting Mammalian Cells from X Radiation and Chemotherapy Agents in Vitro

    • Dennis C. Shrieve
    Pages 249-253
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Keywords

About this book

Acquisition of new knowledge about the biological and bio­ chemical nature of neoplastic cells has led to the design and development of several experimental approaches in the tre&tment of cancer. These approaches emerge from the recent work in tu­ mor virology, e. g. the control of vital cellular genes by viral regulatory signals; the implication of monoclonal antibodies as a vehicle for the targeted drug delivery and selective de­ struction of tumor cells; immunologic advances in the recog­ nition of some specific events during metastatic growth; the role of biological response modifiers in modifying or rever­ sing malignant growth; and biochemical advances, such as the role of gene amplification in drug resistance and the app­ roaches to the reversal of resistance in drug refractory cancer, the role of membranes in designing useful strategies, the identification of new enzymic targets in some types of cancer cells, and the characterization of metabolically active forms of cytostatic compounds. These are the important issues which were addressed in an international NATO Advanced Study Institute (ASI) attended by scientists from allover the world representing a wide spectrum of scientific disciplines. Although the acquired immune deficiency syndrome (AIDS) is not a malignant disease, but the etiological involvement of a retrovirus belonging to the family of human T-cell lympho­ tropic viruses which cause leukemia and lymphomas in man, justifies its inclusion in the agenda of this Study Institute. Scientific presentations from Drs.

Editors and Affiliations

  • University of Frankfurt, Frankfurt am Main, Federal Republic of Germany

    Prakash Chandra

Bibliographic Information

  • Book Title: New Experimental Modalities in the Control of Neoplasia

  • Editors: Prakash Chandra

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-5242-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1986

  • Softcover ISBN: 978-1-4684-5244-0Published: 12 December 2012

  • eBook ISBN: 978-1-4684-5242-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 402

  • Number of Illustrations: 80 b/w illustrations

  • Topics: Biochemistry, general

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