Influenza

1. Front Matter

   Pages i-xxi

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. History of Influenza

      • Edwin D. Kilbourne

      Pages 3-22

3. The Influenza Viruses

   1. Front Matter

      Pages 23-23

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   2. Taxonomy and Comparative Virology of the Influenza Viruses

      • Edwin D. Kilbourne

      Pages 25-32

   3. Viral Structure and Composition

      • Edwin D. Kilbourne

      Pages 33-56

   4. Replication of Influenza Viruses

      • Edwin D. Kilbourne

      Pages 57-87

   5. Cytopathogenesis and Cytopathology of Influenza Virus Infection of Cells in Culture

      • Edwin D. Kilbourne

      Pages 89-110

   6. Influenza Virus Genetics, Viral Adaptation, and Evolution

      • Edwin D. Kilbourne

      Pages 111-154

4. Influenza: Infection and Disease

   1. Front Matter

      Pages 155-155

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   2. Influenza in Man

      • Edwin D. Kilbourne

      Pages 157-218

   3. The Laboratory Diagnosis of Influenza

      • Edwin D. Kilbourne

      Pages 219-228

   4. Animal Influenza

      • Edwin D. Kilbourne

      Pages 229-251

5. Epidemiology, Surveillance, and Control

   1. Front Matter

      Pages 253-253

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   2. The Epidemiology of Influenza

      • Edwin D. Kilbourne

      Pages 255-289

   3. The Control of Influenza

      • Edwin D. Kilbourne

      Pages 291-345

6. Back Matter

   Pages 347-359

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My lifetime encompasses the postwar subsidence in the early 1920s of the greatest influenza pandemic in history, direct encounters with FM1 virus at Fort Mon­ mouth in 1947, the care of influenza patients in the 1950s, the pursuit of the in­ fluenza virus through the modern pandemics of 1957 and 1968, and a present in which the genes of the virus have dissembled in the DNA of vaccinia virus and Escherichia coli through the wand of "high tech. " If my corpus could be fossilized for archival and archaeological purposes, it would be found to contain immune cells branded with the imprint of the "swine" influenza virus of post-1918 and brain cells no less imprinted with memories of the abortive return of its descendant during America's bicentennial. But before that unlikely event, I wanted to try to make some sense out of this baffling dis­ ease and its viruses-expecting no definitive revelations but hoping for a sharper definition of problems. Hence this book. It is an audacious act in these days of specialization to essay a book such as this singlehandedly, but I have done so for selfish reasons. I wanted to reexam­ ine old questions about the nature of influenza and its epidemics in the light of the dazzling advances in molecular biology of the past few years. No virus has been better studied, but few diseases are less well understood.

• biology
• epidemics
• molecular biology
• pandemics
• virus
• infectious diseases

• Mount Sinai School of Medicine, City University of New York, New York, USA

  Edwin D. Kilbourne

Policies and ethics