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Mechanisms of Secondary Brain Damage

  • Book
  • © 1986

Overview

Editors:
  1. A. Baethmann

    1. University of Munich, Munich, West Germany

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  2. K. G. Go

    1. University of Groningen, Groningen, Holland

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  3. A. Unterberg

    1. University of Munich, Munich, West Germany

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Part of the book series: NATO Science Series A: (NSSA, volume 115)

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-x
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  2. Neuropathology of Primary and Secondary Brain Damage

    1. Head Injury

      1. Primary Brain Damage in Non-Missile Head Injury
        • J. Hume Adams, D. I. Graham, T. A. Gennarelli
        Pages 1-13
      2. Diffuse Axonal Injury — A New Conceptual Approach to an Old Problem
        • Thomas A. Gennarelli, J. H. Adams, D. I. Graham
        Pages 15-28
      3. Histopathology and Computerized Tomography of Human Traumatic Cerebral Swelling
        • Raymond A. Clasen, P. Guariglia, R. J. Stein, S. Pandolfi, J. J. Lobick
        Pages 29-45
      4. The Temporal Genesis of Primary and Secondary Brain Damage in Experimental and Clinical Head Injury
        • Donald P. Becker
        Pages 47-64

    2. Cerebral Ischemia

      1. Evolution of Neuronal Ischemic Injury
        • Julio H. Garcia, K. A. Conger
        Pages 65-83
      2. Secondary Changes in Human and Experimental Brain Infarction with Particular Consideration of Microembolism
        • K. J. Zülch
        Pages 85-97
      3. Ischemic Brain Damage in the Rat in a Long Term Recovery Model
        • Roland N. Auer, M.-L. Smith, B. K. Siesjö
        Pages 99-108
      4. Microthrombosis: A Contributing Factor to the Progression of Cerebral Infarction in Man
        • J. Cervos-Navarro, J. Figols, G. Ebhardt
        Pages 109-119
      5. The CT Normal But Low Flow Infarct Periphery: Selective Neuronal Necrosis?
        • Jens Astrup, M. Nedergaard, L. Klinken
        Pages 121-126

  3. Pathophysiological and Biochemical Mechanisms

    1. Cerebral Edema

      1. Disturbances of Extracellular Homeostasis after a Primary Insult as a Mechanism in Secondary Brain Damage
        • K. G. Go
        Pages 127-137
      2. Role of Mediator Compounds in Secondary Brain Damage — Current Evidence
        • Andreas Unterberg, K. Maier-Hauff, C. Dautermann, U. Hack, L. Schürer, A. Baethmann
        Pages 139-150
      3. Neurochemical Sequelae of Brain Damage and Their Role in Functional Disturbances
        • Hanna M. Pappius, L. S. Wolfe
        Pages 151-167
      4. Changes in Brain Edema Movement Following Experimental Brain Insults and Acute Therapy
        • Hector E. James, R. Werner, M. del Bigio
        Pages 169-178
      5. Disturbances of Cellular Membranes and Membrane-Bound Enzymes in Cryogenic Brain Edema
        • Francois Cohadon, N. Averet, M. Rigoulet
        Pages 179-189
      6. Modifications of cAMP and Creatine Kinase-Isoenzymes in CSF in Experimental Head Injury
        • Raffael Vara-Thorbeck, M. Ruiz-Morales
        Pages 191-201
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Keywords

About this book

A distinction between primary and secondary brain damage of vari­ ous origin, particularly in acute lesions, such as head injury and ische­ mia is not entirely new. The concept is of practical significance, be­ cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam­ age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent scientists and clinicians from various fields to pro­ vide a competent introduction and survey of the various aspects involved in secondary brain damage. It was attempted to provide criteria for the distinction between the primary and secondary phenomena on a morpho­ logical and functional level, on the basis of the kinetics involved and, most importantly, regarding the different specific manifestations, such as disturbances of microcirculation, aspects of the blood-brain barrier, and of cellular structure and function at a molecular level. Although it was not expected that a grand unifying hypothesis will be reached recon­ cilable with the many, occasionally opposing views on such a complex subject, nevertheless, the present volume attains an appropriate result. It can best be described as a mosaic of many different pieces which only as an ensemble reflect the current state of the art.

Editors and Affiliations

  • University of Munich, Munich, West Germany

    A. Baethmann, A. Unterberg

  • University of Groningen, Groningen, Holland

    K. G. Go

Bibliographic Information

  • Book Title: Mechanisms of Secondary Brain Damage

  • Editors: A. Baethmann, K. G. Go, A. Unterberg

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-5203-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1986

  • Softcover ISBN: 978-1-4684-5205-1Published: 25 November 2012

  • eBook ISBN: 978-1-4684-5203-7Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: X, 406

  • Number of Illustrations: 105 b/w illustrations

  • Topics: Organic Chemistry

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