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Gene Transfer

  • Book
  • © 1986

Overview

Editors:
  1. Raju Kucherlapati

    1. Center for Genetics, University of Illinois College of Medicine, Chicago, USA

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Gene Transfer: A Perspective

    • Frank H. Ruddle
    Pages 1-4

  3. Cell Hybridization and the 24 Human Gene Maps

    • Thomas B. Shows
    Pages 5-78

  4. Microcell Fusion and Mammalian Gene Transfer

    • Tracy G. Lugo, R. E. K. Fournier
    Pages 79-93

  5. Use of Metaphase-Chromosome Transfer for Mammalian Gene Mapping

    • David E. Housman, David L. Nelson
    Pages 95-115

  6. Vectors for Gene Transfer Derived from Animal DNA Viruses: Transient and Stable Expression of Transferred Genes

    • Vijay R. Baichwal, Bill Sugden
    Pages 117-148

  7. Retrovirus Vectors for Gene Transfer: Efficient Integration into and Expression of Exogenous DNA in Vertebrate Cell Genomes

    • Howard M. Temin
    Pages 149-187

  8. Transgenic Mice: Gene Transfer into the Germ Line

    • Shirley M. Tilghman, Arnold J. Levine
    Pages 189-221

  9. Expression of Transfected Genes

    • Moses V. Chao
    Pages 223-241

  10. Mutation of Autonomously Replicating Plasmids

    • Michele P. Calos
    Pages 243-261

  11. Gene Purification by Transfection Methods

    • Angel Pellicer
    Pages 263-287

  12. Applications of Gene Transfer in the Analysis of Gene Amplification

    • G. M. Wahl, S. Carroll, P. Gaudray, J. Meinkoth, J. Ruiz
    Pages 289-323

  13. Retroviral Integration and Insertional Mutagenesis

    • Stephen P. Goff
    Pages 325-361

  14. Homologous Recombination in Mammalian Somatic Cells

    • Raju Kucherlapati
    Pages 363-381

  15. Intrachromosomal Recombination in Mammalian Cells

    • Anthea Letsou, R. Michael Liskay
    Pages 383-409

  16. Developments Leading to Human Gene Therapy

    • John W. Belmont, C. Thomas Caskey
    Pages 411-441

  17. Back Matter

    Pages 443-447
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Keywords

About this book

Genetic analysis of microbial systems provided us with the foundation for un­ derstanding gene structure, expression, and regulation. It was long felt that the ability to generate mutants and conduct genetic studies in mammalian systems would prove to be equally useful. However, genetic analysis based on sexual systems is difficult in mammals because of the long generation times and the inability to perform controlled matings. As a result, genetic analysis of mam­ malian systems had to await the development of parasexual systems. This book is an attempt to bring together descriptions of a number of these parasexual systems. A common theme of all the parasexual systems is the transfer of genetic information from a defined source into a specific cell type. This volume deals with a number of methods of gene transfer into mammalian cells. The early methods of gene transfer involved transfer of relatively large amounts of genetic information. These include somatic cell hybridization, microcell fusion, and chromosome transfer, which constitute the first part of this book. Each of these methods has already proven to be of enormous value in arriving at a genetic understanding of the mammalian genome. Development of recombinant DNA methods, and the ability to introduce purified DNA into mammalian cells, has had a significant impact on our ability to dissect important aspects of mammalian gene expression and regulation. The second part of this book deals with gene transfer systems involving defined nucleic acid sequences.

Editors and Affiliations

  • Center for Genetics, University of Illinois College of Medicine, Chicago, USA

    Raju Kucherlapati

Bibliographic Information

  • Book Title: Gene Transfer

  • Editors: Raju Kucherlapati

  • DOI: https://doi.org/10.1007/978-1-4684-5167-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1986

  • Softcover ISBN: 978-1-4684-5169-6Published: 30 March 2012

  • eBook ISBN: 978-1-4684-5167-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 462

  • Topics: Human Genetics, Animal Anatomy / Morphology / Histology, Plant Sciences

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