This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.
Editors and Affiliations
Thomas Jefferson University, Philadelphia, USA
James J. Kocsis
Medical University of South Carolina, Charleston, USA
David J. Jollow
Rutgers University, Piscataway, USA
Charlotte M. Witmer,
Robert Snyder
University of Maryland, College Park, USA
Judd O. Nelson
Bibliographic Information
Book Title: Biological Reactive Intermediates III
Book Subtitle: Mechanisms of Action in Animal Models and Human Disease
Editors: James J. Kocsis, David J. Jollow, Charlotte M. Witmer, Judd O. Nelson, Robert Snyder
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1986
Softcover ISBN: 978-1-4684-5136-8Published: 01 September 2013
eBook ISBN: 978-1-4684-5134-4Published: 06 December 2012
