Genetic Engineering of Animals

1. Front Matter

   Pages i-viii

   PDF

2. Introduction

   1. Introduction

      • J. Warren Evans

      Pages 1-2

3. Welcome: Challenges Encountered by the College of Agricultural and Environmental Sciences

   1. Welcome: Challenges Encountered by the College of Agricultural and Environmental Sciences

      • Charles E. Hess

      Pages 3-6

4. Concepts in Genetic Engineering

   1. Genetic Engineering of Animals

      • W. French Anderson

      Pages 7-13

   2. Manipulation of Genes in Vitro and in Vivo

      • Dean H. Hamer

      Pages 15-18

   3. Expression of the Bovine Growth Hormone Gene in Cultured Rodent Cells

      • John J. Kopchick, Francoise Pasleau, Frederick C. Leung

      Pages 19-37

5. Sources of Genetic Material

   1. Mapping Genes in Domesticated Animals

      • Frank H. Ruddle, Rudolf Fries

      Pages 39-57

   2. Gene Transfer into Animals by Retroviral Vectors

      • W. F. Anderson, P. W. Kantoff, M. A. Eglitis, E. Gilboa

      Pages 59-65

   3. Booroola (F) Gene: Major Gene Affecting Ovine Ovarian Function

      • B. M. Bindon, L. R. Piper

      Pages 67-93

   4. Casein Genes and Genetic Engineering of the Caseins

      • Young Kang, Rafael Jimenez-Flores, Tom Richardson

      Pages 95-111

   5. Avian Hormones

      • Frederick C. Leung

      Pages 113-125

6. Applications in Laboratory and Domestic Animals: Overview and History

   1. History of Genetic Engineering of Laboratory and Farm Animals

      • Caird E. Rexroad Jr.

      Pages 127-138

   2. Genetic Analysis in Mammals: Past, Present, and Future

      • Stephen J. O’Brien

      Pages 139-149

   3. Introduction and Regulation of Cloned Genes for Agricultural Livestock Improvement

      • Thomas E. Wagner

      Pages 151-161

   4. A Technique for Bisection of Embryos to Produce Identical Twins

      • Susan E. Donahue

      Pages 163-173

   5. Production of Experimental Chimeras in Livestock by Blastocyst Injection

      • James E. Butler

      Pages 175-185

   6. Gene Transfer by Direct Pronuclei Microinjection

      • Albert W. Tam

      Pages 187-194

7. Applications in Laboratory and Domestic Animals: Disease Aspects

   1. Application of Bioengineering to Disease Diagnosis

      • Bennie I. Osburn

      Pages 195-205

   2. Recombinant DNA Approaches to Feline Leukemia Virus Immunization

      • Paul Luciw, Debbie Parkes, Gary Van Nest, Dino Dina, Kathleen Hendrix, Murray B. Gardner

      Pages 207-215

   3. Molecular Approaches to Vaccines

      • Howard L. Bachrach

      Pages 217-242

J. Warren Evans Department of Animal Science Texas A&M University College Station, Texas 77843 In the near future, improvement of domestic animals for the production of food and fiber is poised to undergo a revolution by the utilization of recent breakthroughs and advances in molecular genetics, embryo manipula­ tions, and gene transfer systems. Utilization of these techniques will have a wide impact on animal agriculture by improvement of production effi­ ciency via manipulation and control of many physiological systems. The end result will be to decrease production costs, increase food production and quality, and lower food costs. Health and well being of domestic and other animals will be improved as a result of new methods of disease diagnosis, vaccine production, and disease prevention practices. Genetic engineering also offers the possibility of utilizing animals for the development of pharmaceutical products to benefit society. Research progress will be en­ hanced via manipulation of the gene pool. The objectives of this Conference were to discuss the current status of animal bioengineering and to realistically assess the potential applica­ tions of current and future genetic technologies for the production of food and fiber to meet the needs of our hungry world, and to provide animal sci­ entists who may wish to utilize bioengineering in current or future re­ search programs with current background information regarding concepts, ap­ plications, and methodologies.

• bioengineering
• gene transfer
• genetic engineering
• genetics
• molecular genetics
• pharmaceutical

• College of Agriculture and Environmental Sciences, University of California, Davis Davis, USA

  J. Warren Evans

• Council for Research Planning in Biological Sciences, Inc., USA

  Alexander Hollaender, Claire M. Wilson

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