Steroid Hormone Resistance

1. Front Matter

   Pages i-xiii

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2. Molecular Actions of Steroid Hormones

   1. Molecular Actions of Steroid Hormones

      • Bert W. O’Malley, William T. Schrader, Ming-Jer Tsai

      Pages 1-10

   2. Steroid Receptor Activation: The Glucocorticoid Receptor as a Model System

      • Gerald Litwack, Thomas J. Schmidt, Andrea Miller-Diener, Maria Webb, Peter Bodine, Carol A. Barnett et al.

      Pages 11-22

   3. “Defective” Receptors in Steroid-Resistant Conditions may be Proteolytic Artifacts

      • Merry R. Sherman, Fe B. Tuazon, Yee-Wan Stevens, Joseph A. Carlino, En-Mei Niu

      Pages 23-51

   4. Characteristics and Specificity of the Glucocorticoid “Carrier” of Rat Liver Plasma Membrane

      • Axel Allera, Govind S. Rao

      Pages 53-65

3. Glucocorticoid Functions and Resistance

   1. Mechanisms of Glucocorticoid Hormone Action

      • Emily P. Slater, Thomas Anderson, Peter Cattini, Randi Isaacs, Morris J. Birnbaum, David G. Gardner et al.

      Pages 67-80

   2. Glucocorticoid Physiology, Pharmacology and Stress

      • Allan Munck, Paul M. Guyre

      Pages 81-96

   3. Cortisol Resistance in Man

      • Mortimer B. Lipsett, Masako Tomita, David D. Brandon, Monique M. De Vroede, D. Lynn Loriaux, George P. Chrousos

      Pages 97-109

   4. Glucocorticoid Receptors and Glucocorticoid Resistance in Human Leukemia in Vivo and in Vitro

      • E. Brad Thompson, Jeffrey M. Harmon

      Pages 111-127

   5. The New World Primates as Animal Models of Glucocorticoid Resistance

      • George P. Chrousos, D. Lynn Loriaux, Masako Tomita, David D. Brandon, David Renquist, Barry Albertson et al.

      Pages 129-144

4. Mineralocorticoid Action and Resistance

   1. Aldosterone Receptors

      • John W. Funder

      Pages 145-152

   2. Models of Aldosterone Action on Sodium Transport: Emerging Concepts

      • Diana Marver

      Pages 153-171

   3. Pseudohypoaldosteronism: A Review and Report of Two New Cases

      • P. W. Speiser, E. Stoner, M. I. New

      Pages 173-195

   4. Animal Models of Mineralocorticoid Resistance

      • Walter J. Meyer III

      Pages 197-211

5. Androgen Action and Resistance

   1. Differential Regulation of Specific Gene Expression in Mouse Kidney by Androgens and Antiandrogens

      • James F. Catterall, Cheryl S. Watson, Kimmo K. Kontula, Olli A. Janne, C. Wayne Bardin

      Pages 213-226

   2. Androgen Receptors in Normal and Abnormal Male Sexual Differentiation

      • Terry R. Brown, Claude J. Migeon

      Pages 227-255

   3. Androgen Resistance in Man

      • William J. Kovacs, James E. Griffin, Jean D. Wilson

      Pages 257-267

   4. Animal Models of Androgen Insensitivity

      • Leslie P. Bullock

      Pages 269-278

   5. High Plasma Steroid Levels in the Squirrel Monkey: Deficient Receptors or Metabolism?

      • Pentti K. Siiteri

      Pages 279-289

6. Female Sex Steroids: New Aspects on the Mechanism of Action and Resistance States

   1. Progesterone Receptor Interaction in the 5’-Flanking Regulatory Region of the Ovalbumin Gene

      • John G. Compton, William T. Schrader, Bert W. O’Malley

      Pages 291-304

This volume represents the first attempt to present in one place the clinical syndromes and the pathophysiologic basis for the "resistance states" to each of the classes of steroid hormones. Glucocorticoids, mineralocorticoids, androgens, estrogens, progesterone and vitamin D have widely diverse roles ranging from the control of homeostasis to reproduction and bone formation. They are similar in that they share a chemical structure and that their action is in the cell nucleus where they induce transcription of specific genes leading to synthesis of function-specific proteins. Clinical syndromes of steroid hormone resistance to androgens (complete and partial testicular feminization), aldosterone (pseudo­ hypoaldosteronism) and vitamin D (vitamin D-dependent rickets type II) have been known for many years. Progesterone and glucocorticoid resistance syndromes have been described only recently. Resistance to estrogens has not been reported in man or in animals. It is hoped that a detailed reexamination of what is known about each of these conditions at the clinical and molecular levels will enhance our understanding of the function of these hormones and their mechanisms of action. New insight and research initiatives should result. G.P. Chrousos D.L. Loriaus M.B. Lipsett vii ACKNOWLEDGMENTS The contents of this volume are based in part on the proceedings of an International Conference held in Bethesda in the summer of 1984. This conference was sponsored by the National Institute of Child Health and Human Development, Bethesda, Maryland.

• Vitamin D
• protein
• proteins
• synthesis
• transcription

• National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA

  George P. Chrousos, D. Lynn Loriaux, Mortimer B. Lipsett

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