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Ionic Channels in Cells and Model Systems

  • Book
  • © 1986

Overview

Editors:
  1. Ramon Latorre

    1. Centro de Estudios Científicos de Santiago and Facultad de Ciencias, Universidad de Chile, Santiago, Chile

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Part of the book series: Series of the Centro De Estudios Científicos (SCEC)

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Introduction

    1. Introduction

      • Ramon Latorre
      Pages 1-2

  3. Methodologies

    1. Front Matter

      Pages 3-3
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    2. Kinetic Models and Channel Fluctuations

      • Osvaldo Alvarez
      Pages 5-15

    3. Single-Channel Currents and Postsynaptic Drug Actions

      • Harold Lecar
      Pages 17-36

    4. Voltage-Dependent Gating

      • Francisco Bezanilla
      Pages 37-52

    5. Characterizing the Electrical Behavior of an Open Channel via the Energy Profile for Ion Permeation

      • George Eisenman, John A. Dani
      Pages 53-87

    6. The Use of Specific Ligands to Study Sodium Channels in Muscle

      • Enrique Jaimovich
      Pages 89-100

    7. Isolation of Muscle Membranes Containing Functional Ionic Channels

      • Cecilia Hidalgo
      Pages 101-125

    8. Methodologies to Study Channel-Mediated Ion Fluxes in Membrane Vesicles

      • Ana Maria Garcia
      Pages 127-140

    9. Optical Studies on Ionic Channels in Intact Vertebrate Nerve Terminals

      • Brian M. Salzberg, Ana Lia Obaid, Harold Gainer
      Pages 141-162

    10. Optical Detection of ATP Release from Stimulated Endocrine Cells

      • Eduardo Rojas, Rosa Maria Santos, Andres Stutzin, Harvey B. Pollard
      Pages 163-178

  4. Channels in Biological Membranes

    1. Front Matter

      Pages 179-179
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    2. Mechanotransducing Ion Channels

      • Frederick Sachs
      Pages 181-193

    3. Ionic Channels in Plant Protoplasts

      • Nava Moran, Gerald Ehrenstein, Kunihiko Iwasa, Charles Bare, Charles Mischke
      Pages 195-205

    4. Channels in Kidney Epithelial Cells

      • Sandra Guggino
      Pages 207-220

    5. Channels in Photoreceptors

      • Juan Bacigalupo
      Pages 221-233

    6. Inactivation of Calcium Currents in Muscle Fibers from Balanus

      • M. Luxoro, V. Nassar-Gentina
      Pages 235-242

    7. Electrophysiological Studies in Endocrine Cells

      • Clay M. Armstrong
      Pages 243-254

  5. Ionic Channel Reconstitution

    1. Front Matter

      Pages 255-255
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Keywords

About this book

This book is based on a series of lectures for a course on ionic channels held in Santiago, Chile, on November 17-20, 1984. It is intended as a tutorial guide on the properties, function, modulation, and reconstitution of ionic channels, and it should be accessible to graduate students taking their first steps in this field. In the presentation there has been a deliberate emphasis on the spe­ cific methodologies used toward the understanding of the workings and function of channels. Thus, in the first section, we learn to "read" single­ channel records: how to interpret them in the theoretical frame of kinetic models, which information can be extracted from gating currents in re­ lation to the closing and opening processes, and how ion transport through an open channel can be explained in terms of fluctuating energy barriers. The importance of assessing unequivocally the origin and purity of mem­ brane preparations and the use of membrane vesicles and optical tech­ niques in the stUGY of ionic channels are also discussed in this section. The patch-clamp technique has made it possible to study ion channels in a variety of different cells and tissues not amenable to more conven­ tional electrophysiological methods. The second section, therefore, deals with the use of this technique in the characterization of ionic channels in different types of cells, ranging from plant protoplasts to photoreceptors.

Editors and Affiliations

  • Centro de Estudios Científicos de Santiago and Facultad de Ciencias, Universidad de Chile, Santiago, Chile

    Ramon Latorre

Bibliographic Information

  • Book Title: Ionic Channels in Cells and Model Systems

  • Editors: Ramon Latorre

  • Series Title: Series of the Centro De Estudios Científicos

  • DOI: https://doi.org/10.1007/978-1-4684-5077-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1986

  • Hardcover ISBN: 978-0-306-42194-5Due: 31 August 1986

  • Softcover ISBN: 978-1-4684-5079-8Published: 14 March 2013

  • eBook ISBN: 978-1-4684-5077-4Published: 11 November 2013

  • Series ISSN: 1571-571X

  • Edition Number: 1

  • Number of Pages: XXIII, 437

  • Number of Illustrations: 37 b/w illustrations

  • Topics: Animal Physiology, Biological and Medical Physics, Biophysics

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