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Regulation of Hepatic Metabolism

Intra- and Intercellular Compartmentation

  • Book
  • © 1986

Overview

Editors:
  1. Ronald G. Thurman

    1. Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, USA

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  2. Frederick C. Kauffman

    1. Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, USA

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  3. Kurt Jungermann

    1. Georg-August Universität, Göttingen, Federal Republic of Germany

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xix
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  2. Liver Structure

    1. Front Matter

      Pages 1-1
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    2. Liver Structure and Innervation

      • Dieter Sasse
      Pages 3-25

    3. Hepatic Hemodynamics and Microcirculation

      • P. G. Withrington, P. D. I. Richardson
      Pages 27-53

  3. Methods

    1. Front Matter

      Pages 55-55
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    2. Histology and Histochemistry

      • Dieter Sasse
      Pages 57-86

    3. Immunohistochemistry

      • Jeffrey Baron, Jeffrey M. Voigt, Thomas T. Kawabata, Jan A. Redick
      Pages 87-118

    4. Quantitative Histochemical Measurements within Sublobular Zones of the Liver Lobule

      • Frederick C. Kauffman, Franz M. Matschinsky
      Pages 119-136

    5. Separation of Functionally Different Liver Cell Types

      • Kai O. Lindros, Gunnar Bengtsson, Mikko Salaspuro, Hannu Väänänen
      Pages 137-158

    6. New Micromethods for Studying Sublobular Structure and Function in the Isolated, Perfused Rat Liver

      • John J. Lemasters, Sungchul Ji, Ronald G. Thurman
      Pages 159-184

    7. Redox Scanning in the Study of Metabolic Zonation of Liver

      • Bjørn Quistorff, Britton Chance
      Pages 185-207

  4. Distribution of Metabolic Functions

    1. Front Matter

      Pages 209-209
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    2. Metabolism of Carbohydrates

      • Kurt Jungermann, Norbert Katz
      Pages 211-235

    3. Metabolism of Lipids

      • Norbert Katz
      Pages 237-252

    4. Metabolism of Amino Acids and Ammonia

      • Dieter Häussinger, Wolfgang Gerok
      Pages 253-291

    5. Lobular Oxygen Gradients: Possible Role in Alcohol-Induced Hepatotoxicity

      • Ronald G. Thurman, Sungchul Ji, John J. Lemasters
      Pages 293-320

    6. Biotransformation and Zonal Toxicity

      • Ronald G. Thurman, Frederick C. Kauffman, Jeffrey Baron
      Pages 321-382

    7. Protein Synthesis and Secretion

      • A. V. LeBouton
      Pages 383-410

    8. Bile Acid Metabolism

      • Jorge J. Gumucio, William F. Balistreri, Fred J. Suchy
      Pages 411-441

  5. Induction of Liver Cell Heterogeneity

    1. Front Matter

      Pages 443-443
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Keywords

About this book

The liver is an exceptionally complex and diverse organ that functions both as an exocrine and an endocrine gland. It secretes bile, which contains many con­ stituents in addition to bile salts, and it synthesizes and releases many substances in response to the body's demands, including prohormones, albumin, clotting factors, glucose, fatty acids, and various lipoproteins. It has a dual blood supply providing a rich mixture of nutrients and other absorbed substances via the portal vein and oxygen-rich blood via the hepatic artery. This functional heterogeneity is accompanied by cellular heterogeneity. The liver contains many cell types including hepatic parachymal cells, Kiipffer cells, Ito cells, and endothelial cells. The most abundant cell type, the parenchymal cells, are biochemically and structurally heterogeneous. The cells in the oxygen-rich areas of the portal triad appear more dependent on oxidative metabolism, whereas those around the central vein (pericentral, perivenous, or centrolobular areas) are more dependent upon an anaerobic mechanism. Throughout this volume the latter three terms are used synonymously by various authors to indicate the five to eight layers of cells radiating from the central vein. Structural and metabolic heterogeneity of hepatic parenchymal cells has been demonstrated by a variety of approaches, including histochemical, ultra­ structural, and ultramicrobiochemical studies. This microheterogeneity is linked to the physiological functions of the liver and its response to injurious substances.

Editors and Affiliations

  • Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, USA

    Ronald G. Thurman

  • Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, USA

    Frederick C. Kauffman

  • Georg-August Universität, Göttingen, Federal Republic of Germany

    Kurt Jungermann

Bibliographic Information

  • Book Title: Regulation of Hepatic Metabolism

  • Book Subtitle: Intra- and Intercellular Compartmentation

  • Editors: Ronald G. Thurman, Frederick C. Kauffman, Kurt Jungermann

  • DOI: https://doi.org/10.1007/978-1-4684-5041-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1986

  • Softcover ISBN: 978-1-4684-5043-9Published: 30 March 2012

  • eBook ISBN: 978-1-4684-5041-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 510

  • Topics: Gastroenterology, Hepatology, Pharmacology/Toxicology

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