Basic and Applied Mutagenesis

1. Front Matter

   Pages i-xi

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Welcoming Address

      • Amir Muhammed

      Pages 3-6

   3. Inaugural Address

      • M. F. Janjua

      Pages 7-10

   4. Toxins in the Human Food System

      • Roger Revelle

      Pages 11-26

3. Risks to Human Health Induced by Pesticides

   1. Front Matter

      Pages 27-27

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   2. General Human Health Risks Associated with the Use of Chemicals

      • Larry L. Deaven

      Pages 29-41

   3. Water Contamination and Environmental Mutagens

      • John C. Loper

      Pages 43-61

   4. Problems Associated with the Use of Chemicals by Agricultural Workers

      • Umar Khan Baloch

      Pages 63-78

   5. Mechanism of Contamination from Agricultural Chemicals in Mammals

      • M. Ataur Rahman

      Pages 79-85

   6. Mycotoxins as Carcinogens

      • Amin M. Hussain

      Pages 87-96

4. Basic Studies Related to Mutagenesis and Carcinogenesis

   1. Front Matter

      Pages 97-97

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   2. Cytotoxicity as a Mechanism of Carcinogenesis

      • Matthews O. Bradley

      Pages 99-109

   3. Mutagenesis-Enhancement by Plasmids in Mutagenesis Tester Strains

      • Graham C. Walker

      Pages 111-120

   4. Situation-Dependent Repair of DNA Damage in Yeast

      • R. C. von Borstel, P. J. Hastings

      Pages 121-145

   5. A Possible Role for Deoxyribonucleotide Pool Imbalances in Carcinogenesis

      • Robert H. Haynes, Bernard A. Kunz

      Pages 147-156

   6. Polysubstrate Monooxygenases in Drosophila, Mammals and Man

      • F. E. Würgler

      Pages 157-182

5. Mutagenic, Teratogenic, and Predictive Carcinogenic Studies of Pesticides

   1. Front Matter

      Pages 183-183

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   2. Evaluation of the Genotoxic Potential of Certain Pesticides Used in Pakistan

      • Shahbeg S. Sandhu, Michael D. Waters, Vincent F. Simmon, Kristien E. Mortelmans, Ann D. Mitchell, Ted Jorgenson et al.

      Pages 185-219

   3. Mutagen Testing of Agricultural Chemicals with Yeast

      • Friederike Eckardt, R. C. von Borstel

      Pages 221-248

The aim of the editors of this volume is to use basic and ap­ plied studies in the field of mutagenesis to approach a problem of especial concern. The problem is that of the usage of toxic chemi­ cals, particularly agricultural chemicals, in ever-increasing quan­ tities in those parts of the world that feed the most people. Agri­ cultural chemicals that are in use in Pakistan are emphasized here. These are the same chemicals that are in use throughout the develop­ ing world, although the quantities of the different types that are used may vary from country to country, and from region to region within countries. A number of these chemicals can no longer be sold in Europe or in the United States, and it is often difficult to iden­ tify a scientific reason as to why they are sold at all. It is ironic that toxic chemicals are used as a humanitarian device to rid the world of Pestilence and Famine -- two of the Horsemen of the Apocalypse. If we do not wish poisonous chemicals to become the fifth Horseman of the Apocalypse, then we must begin now to identify and regulate the large-scale usage of toxic sub­ stances everywhere.

• DNA
• mutagen
• mutagenesis

• Pakistan Agricultural Research Council, Islamabad, Pakistan

  Amir Muhammed

• The University of Alberta, Edmonton, Canada

  R. C. Borstel, Dorothy Woslyng

Policies and ethics