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Assessment of Risk from Low-Level Exposure to Radiation and Chemicals

A Critical Overview

  • Book
  • © 1985

Overview

Editors:
  1. Avril D. Woodhead

    1. Brookhaven National Laboratory, Upton, USA

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  2. Claire J. Shellabarger

    1. Brookhaven National Laboratory, Upton, USA

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  3. Virginia Pond

    1. Brookhaven National Laboratory, Upton, USA

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  4. Alexander Hollaender

    1. Council for Research Planning in Biological Sciences, Inc., USA

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Part of the book series: Basic Life Sciences (BLSC, volume 33)

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Dedication: To Our Colleague and Friend Dr. Charles Little Dunham

    1. Dedication: To Our Colleague and Friend Dr. Charles Little Dunham

      • Avril D. Woodhead, Claire J. Shellabarger, Virginia Pond, Alexander Hollaender
      Pages 1-1

  3. Keynote Address

    1. Epidemiological Reservations about Risk Assessment

      • Richard Peto
      Pages 3-16

  4. Report of National Cancer Institute Symposium: Comparison of Mechanisms of Carcinogenesis by Radiation and Chemical Agents

    1. Common Molecular Mechanisms

      • Donald C. Borg
      Pages 17-42

    2. Cellular and Animal Models

      • R. J. M. Fry
      Pages 43-63

  6. Biological Mechanisms: Single Cells

    1. The Isolation and Characterization of the Blym-1 Transforming Gene

      • Alan Diamond, Joan M. Devine, Mary-Ann Lane, Geoffrey M. Cooper
      Pages 141-152

    2. Retroviral Oncogenes and Human Neoplasia

      • E. Premkumar Reddy
      Pages 153-168

    3. Mutation in Single-Cell Systems Induced by Low-Level Mutagen Exposure

      • Howard L. Liber, Susan L. Danheiser, William G. Thilly
      Pages 169-204

    4. Quantitative Neoplastic Transformation in C3H/10T1/2 Cells

      • John S. Bertram, John E. Martner
      Pages 205-222

  7. Modification of the Response

    1. Risk Estimate for Genetic Effects

      • Seymour Abrahamson
      Pages 223-250

    2. Saturation of Repair

      • R. B. Setlow
      Pages 251-260

    3. Role of Tumor Promotion in Affecting the Multi-Hit Nature of Carcinogenesis

      • James E. Trosko, Chia-cheng Chang
      Pages 261-284

    4. Genetic and Epigenetic Aspects of Tumor Progression and Tumor Heterogeneity

      • R. G. Liteplo, P. Frost, R. S. Kerbel
      Pages 285-305
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Keywords

About this book

The present workshop had its orlglns in discussions among Alexander Hollaender, Oddvar Nygaard, Donald Borg, Richard Setlow and Victor Bond on the need for a symposium that would deal with a broad spectrum of pressing subjects related to the physics, chemistry, and biological actions of ionizing radiations, and the theoretical and practical problems of risk assessment. It soon became apparent that the spectrum of subjects considered was too broad for the desired depth of coverage; in fact, it seemed un­ likely that the conference participants would have the background knowledge to span the gamut. Therefore, two separate meetings were decided upon, the first of which, Comparison of Mechanisms of Carcinogenesis by Radiation and Chemical Agents, was held at the National Bureau of Standards, Gaithersburg on December 6-7, 1983. The meeting was sponsored by the NCI. The second meeting has emerged as the present workshop at Brookhaven National Laboratory. An interface between the two conferences has been provided by Michael Fry and Donald Borg, who have summarized the salient points emanating from the NCI Symposium. We intended that the first conference should focus on the basic mechanisms of radiation and chemical carcinogenesis, while the second, the present meeting, would emphasize exposure-response relationships, particularly the theoretical and practical similar­ ities and differences between exposure to chemical carcinogens compared to exposure to ionizing radiation.

Editors and Affiliations

  • Brookhaven National Laboratory, Upton, USA

    Avril D. Woodhead, Claire J. Shellabarger, Virginia Pond

  • Council for Research Planning in Biological Sciences, Inc., USA

    Alexander Hollaender

Bibliographic Information

  • Book Title: Assessment of Risk from Low-Level Exposure to Radiation and Chemicals

  • Book Subtitle: A Critical Overview

  • Editors: Avril D. Woodhead, Claire J. Shellabarger, Virginia Pond, Alexander Hollaender

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4684-4970-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1985

  • Softcover ISBN: 978-1-4684-4972-3Published: 25 November 2012

  • eBook ISBN: 978-1-4684-4970-9Published: 21 November 2013

  • Edition Number: 1

  • Number of Pages: XII, 529

  • Topics: Public Health

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