Gene Expression in Muscle

1. Front Matter

   Pages i-x

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2. Background

   1. Front Matter

      Pages 1-1

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   2. Clinical Perspective: Phenotypic Expression in Muscular Dystrophy

      • Lewis P. Rowland

      Pages 3-14

   3. Ontologic Perspective: Terminal Differentiation and Maturation as Differently Regulated Stages in Muscle Development

      • Richard C. Strohman, Stewart Wolf

      Pages 15-22

3. Phenotypic Expression & Molecular Markers for Muscle Diseases

   1. Front Matter

      Pages 23-23

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   2. Hereditary Metabolic Myopathies

      • Armand F. Miranda, Tiziana Mongini, Salvatore DiMauro

      Pages 25-42

   3. Myosin Isoforms in Normal and Dystrophic Human and Murine Muscles

      • Joseph F. Y. Hoh, R. B. Fitzsimons

      Pages 43-62

   4. Distribution of Slow Myosin in Dystrophic Chicken Muscle

      • Everett Bandman

      Pages 63-72

   5. Satellite Cells in Normal, Regenerating and Dystrophic Muscle

      • Edward Schultz

      Pages 73-84

   6. Evidence for Defective Myoblasts in Duchenne Muscular Dystrophy

      • Helen M. Blau, Cecilia Webster, Grace K. Pavlath, Choy-Pik Chiu

      Pages 85-110

4. Regulatory Influences on Muscle Growth

   1. Front Matter

      Pages 111-111

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   2. Trophic Influences on Developing Muscle

      • S. Hauschka, R. Lim, C. Clegg, J. Chamberlain, C. Bulinski, T. Linkhart

      Pages 113-122

   3. Trophic and Myogenic Effects with Special Reference to Transferrin

      • Eijiro Ozawa

      Pages 123-127

   4. Stimulation of the Synthesis of Fructose 1,6-Diphosphate Aldolase by Transferrin

      • T. H. Oh, G. J. Markelonis, T. Dion Guidera, S. L. Hobbs, L. P. Park

      Pages 129-135

   5. Myotrophic Factor(s) in Normal and Dystrophic Chicken Skeletal Muscle

      • Ryoichi Matsuda, Richard C. Strohman

      Pages 137-140

   6. Control of Myosin Isozymes during Myogenesis in the Rat

      • Neal A. Rubinstein, Gary E. Lyons, Brigitte Gambke, Alan Kelly

      Pages 141-153

   7. Influences of Testosterone on Contractile Proteins of the Guinea Pig Temporalis Muscle

      • A. Kelly, G. Lyons, B. Gambki, N. Rubinstein

      Pages 155-168

   8. Alterations in Phenotype Expression of Muscle by Chronic Nerve Stimulation

      • Dirk Pette, Annegard Heilig, Gary Klug, Heinz Reichmann, Udo Seedorf, Walter Wiehrer

      Pages 169-177

   9. Induction of Incoordinate Synthesis of Muscle Proteins by the Tumor Promoter TPA and the Carcinogen EMS

      • H. Holtzer, S. Forry-Schaudies, P. Antin, G. Dubyak, V. Nachmias

      Pages 179-192

   10. Synthesis and Accumulation of Myosin Isozymes in Tissue Culture

       • Robert G. Whalen, Lawrence B. Bugaisky, Gillian S. Butler-Browne, Marion S. Ecob, Christian Pinset

       Pages 193-199

This volume contains the edited transcript of an interdisci­ plinary colloquium held at Totts Gap Medical Research Laboratories, Bangor, Pennsylvania on October 12-14, 1983 under the sponsorship of the Muscular Dystrophy Association. The aim was to illuminate the pathogenic mechanism of Duchenne Muscular Dystrophy through a synthesis of available data on gene expression in muscle. In the informal give and take ot the collo­ quium, the participants found themselves engaged in mutual education and enlightenment as they attempted to put together what is known and to highlight what is not known about the subject. Significant research into muscle as a tissue and muscle disease began only about 50 years ago although the description of muscular dystrophy by Guillaume Benjamin Amand Duchenne de Boulogne had been published in 1862. By 1943 it was clear that Duchenne muscular dystrophy was an X-linked genetic disorder. Up to the present, however, the offending gene has not been identified although its location on the short arm of the X chromosome has been approximately determined. The gene product associated with the initial disturbance in skeletal muscle has also remained elusive up to now. Moreover, investigations into the mechanisms of the muscle degeneration have been hampered by ignorance of the fundamental phenotypic expression of the genetic disorder.

• chromosome
• gene expression
• genes

• University of California, Berkeley, USA

  Richard C. Strohman

• Totts Gap Medical Research Laboratories, Bangor, USA

  Stewart Wolf

• Temple University, Philadelphia, USA

  Stewart Wolf

Policies and ethics