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Sister Chromatid Exchanges

25 Years of Experimental Research Part B Genetic Toxicology and Human Studies

  • Book
  • © 1984

Overview

Editors:
  1. Raymond R. Tice

    1. Medical Department, Brookhaven National Laboratory, Upton, USA

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  2. Alexander Hollaender

    1. Council for Research Planning in Biological Sciences, Inc, NW, USA

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  3. Bo Lambert

    1. Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden

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  4. Kanehisa Morimoto

    1. Department of Public Health, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan

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  5. Claire M. Wilson

    1. Council for Research Planning in Biological Sciences, Inc, USA

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Part of the book series: Basic Life Sciences (BLSC, volume 29)

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Table of contents (38 chapters)

  1. Front Matter

    Pages i-xvii
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  2. SCE and Genetic Toxicology

    3. In Vivo Mammalian Systems

      1. Development of Rodent Peripheral Blood Lymphocyte Culture Systems to Detect Cytogenetic Damage In Vivo
        • A. D. Kligerman, G. L. Erexson, J. L. Wilmer
        Pages 569-584
      2. Accumulation of SCEs in Lymphocytes During Chronic Ingestion of a Mutagen
        • A. F. McFee, M. N. Sherrill
        Pages 585-594
      3. Elimination of Cyclophosphamide-Induced SCE in Lymphocytes of Rats with Time Post-Treatment
        • Armin Basler
        Pages 595-598
      4. Detection of SCE in Rodent Cells Using the Activated Charcoal Bromodeoxyuridine System
        • Pedro Morales-Ramírez, Teresita Vallarino-Kelly, Regina Rodríguez-Reyes
        Pages 599-611
      5. Assessment of Sister Chromatid Exchange in Spermatogonia and Intestinal Epithelium in Chinese Hamsters
        • Steven B. Neal, Gregory S. Probst
        Pages 613-628
      6. Sister Chromatid Exchanges in Mammalian Meiotic Chromosomes
        • J. W. Allen, C. W. Gwaltney
        Pages 629-645

  3. Human Studies

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Keywords

About this book

Chromosomes, being well-defined structures that are easily vis­ ible under the optical microscope, readily lend themselves to in­ tense physical and biochemical study. The understanding of the structure and function of this most critical genetic material has progressed through a number of interesting stages. Often connected with the development of new techniques in staining and photography, using the standard microscope and the electron microscope. It is interesting to look back at the history of cytogenetics. I would like especially to emphasize the work of Karl Sax and many of his students. Work with Tradescantia became feasible after Edgar Anderson straightened out the ecology and Sax took advantage of the small number of chromosomes easily visible under the microscope. As a matter of fact, this development is seen as the foundation for the quantitative analysis of radiation effects on chromosomes. During the 50 years since then, more refined studies have been initiated. The study of cytogenetic mechanisms has become an important tool for the recognition of the effects of environmental factors on all liv­ ing systems and has made SCE studies possible. One of the most important stages in chromosome research was the development, in radiation biology, of radiolabeling the chromosome with tritiated thymidine. This technique, published in 1957 by Dr.

Editors and Affiliations

  • Medical Department, Brookhaven National Laboratory, Upton, USA

    Raymond R. Tice

  • Council for Research Planning in Biological Sciences, Inc, NW, USA

    Alexander Hollaender

  • Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden

    Bo Lambert

  • Department of Public Health, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan

    Kanehisa Morimoto

  • Council for Research Planning in Biological Sciences, Inc, USA

    Claire M. Wilson

Bibliographic Information

  • Book Title: Sister Chromatid Exchanges

  • Book Subtitle: 25 Years of Experimental Research Part B Genetic Toxicology and Human Studies

  • Editors: Raymond R. Tice, Alexander Hollaender, Bo Lambert, Kanehisa Morimoto, Claire M. Wilson

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4684-4892-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1984

  • Softcover ISBN: 978-1-4684-4894-8Published: 16 February 2013

  • eBook ISBN: 978-1-4684-4892-4Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: XVII, 1033

  • Topics: Pharmacology/Toxicology

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