Neurotransmitter Receptors

1. Front Matter

   Pages i-xi

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2. Coupling of Neurotransmitter Receptors to Adenylate Cyclase

   1. Selective Blockage by Islet-Activating Protein, Pertussis Toxin, of Negative Signal Transduction from Receptors to Adenylate Cyclase

      • Michio Ui, Toshiaki Katada, Toshihiko Murayama, Hitoshi Kurose

      Pages 1-16

   2. A Central Role for Magnesium in the Regulation of Inhibitory Adenosine Receptors

      • Dermot M. F. Cooper, Siu-Mei Helena Yeung, Edward Perez-Reyes, Linda H. Fossom

      Pages 17-30

   3. Role of Hormone-Sensitive GTPases in Adenylate Cylase Regulation

      • Klaus Aktories, Günter Schultz, Karl H. Jakobs

      Pages 31-45

   4. Reconstitution of the Regulatory Functions of β-Adrenergic Receptors

      • Elliott M. Ross, Tomiko Asano, Steen E. Pedersen, Douglas R. Brandt

      Pages 47-62

   5. Regulation of the Catalytic Unit of Adenylate Cyclase System in Rat Brain

      • S. Ishibashi, T. Kurokawa, K. Higashi, T. Dan’ura

      Pages 63-74

   6. Molecular Regulatory Mechanism of D2 Dopamine Receptor in the Bovine Striatum

      • Chikako Tanaka, Takayoshi Kuno, Osamu Shirakawa, Kiyofumi Saijoh, Nobuo Kubo

      Pages 75-84

   7. Genetic and Functional Studies of Guanine Nucleotide-Binding Regulatory Proteins

      • Henry R. Bourne, Cornelis Van Dop, Gerald F. Casperson

      Pages 85-98

3. Regulation, Interactions, and Coupling to Effectors

   1. Differential Regulation of Putative M1/M2 Muscarinic Receptors: Implications for Different Receptor-Effector Coupling Mechanisms

      • Thomas W. Vickroy, Mark Watson, Henry I. Yamamura, William R. Roeske

      Pages 99-114

   2. Factors Regulating Ligand Binding to 5-Hydroxytryptamine Receptors in Rat Brain

      • Tomio Segawa, Yasuyuki Nomura, Hiroaki Nishio, Jun-ichi Taguchi, Mutsuko Fujita

      Pages 115-125

   3. Evidence for Alpha2 Adrenergic Receptors in Bovine Cerebral Arteries

      • Takashi Taniguchi, Motohatsu Fujiwara, Tetsuya Tsukahara, Hajime Handa

      Pages 127-132

   4. Modulation of Alpha2-Adrenergic Receptors of Rat Vas Deferens by Adenosine Receptors

      • Yashiro Watanabe, Hiroshi Yoshida

      Pages 133-143

   5. Neuromodulatory Roles of Adenosine Receptors Coupling to the Calcium Channel and Adenylate Cyclase

      • Yoichiro Kuroda

      Pages 145-158

   6. Interaction of Enkephalin with Opioid Receptors of Brain Membranes: Regulation by Essential Transition Metals, Guanine Nucleotides and Temperature

      • Norio Ogawa, Sachiko Mizuno, Akitane Mori

      Pages 159-171

   7. Ca2+-Activated, Fatty Acid-Dependent Guanylate Cyclase in Synaptic Plasma Membranes and Its Requirement for Ca2+ and Mg-GTP in the Activation

      • Takeo Asakawa, Masako Takano, Keiichi Enomoto, Kazuko Hayama

      Pages 173-186

   8. Modulation of Neuroreceptor Functions by Lipomodulin, a Phospholipase Inhibitory Protein

      • Fusao Hirata, Yoshitada Notsu, Keiichi Matsuda, Toshio Hattori

      Pages 187-192

4. Receptor Structure, Localization, and Ion Channels

   1. Ontogenetic Development of the Specific [3H]Nitrendipine Binding Sites in the Rat Whole Brain

      • H. Matsubayashi, S. Kito, E. Itoga, K. Mizuno, R. Miyoshi

      Pages 193-204

   2. Biochemical Properties of the GABA/Barbiturate/Benzodiazepine Receptor-Chloride Ion Channel Complex

      • R. W. Olsen, E. H. F. Wong, G. B. Stauber, D. Murakami, R. G. King, J. B. Fischer

      Pages 205-219

   3. Purification of γ-Aminobutyric Acid (GABA) and Benzodiazepine Receptors from Rat Brain Using Benzodiazepine-Affinity Column Chromatography

      • Kinya Kuriyama, Jun-ichi Taguchi

      Pages 221-233

   4. Structure and Properties of the Brain GABA/Benzodiazepine Receptor Complex

      • Eric A. Barnard, F. Anne Stephenson, Erwin Sigel, Cleanthi Mamalaki, Graeme Bilbe, Andrew Constanti et al.

      Pages 235-254

This meeting was held commemorating Dr. Kito's 10th Anniversary as Professor of the Third Department of Internal Medicine, Hiroshima University School of Medicine. Dr. Kito was born in 1927 in Nagoya, graduated from Tokyo University School of Medicine and received his M. D. in 1951. He spent his first academic years as a research associate (1952 - 1968) at the Third Department of Internal Medi­ cine, Tokyo University School of Medicine. During this period he studied for one year (1952 - 1953) at Illinois University School of Medicine, and acquired his Ph. D. in 1959. In 1968 he became Instructor and in 1971 he was appointed as Assistant Professor of Tokyo Women's Medical College. In 1973, he became Professor of the Third Department of Internal Medicine, Hiroshima University School of Medicine. Dr. Kito is a clinician but he is always enthusiastic about basic medicine. His major research field concerns neurotrans­ mitters and their receptors in the central nervous system. He prefers a combination of neurotransmitter immunohistochemistry and receptor autoradiography as research techniques. He is also engaged in biochemical studies on amyloid proteins. When the Eighth Inter­ national Congress of Pharmacology was held in Tokyo in 1981, Dr. Segawa, Dr. Yamamura, and Dr. Kuriyama organized a Satellite Symposium on Neurotransmitter Receptors in Hiroshima. Dr. Kito attended this meeting and was deeply impressed by the active presentations and discussions. In order to make some contribution to the progress of neuro­ sciences, Dr.

• adenosine
• brain
• evolution
• medicine
• nervous system
• proteins
• research
• system
• university

• Third Department of Internal Medicine, Hiroshima University School of Medicine, Minamiku, Hiroshima 734, Japan

  Shozo Kito

• Department of Pharmacology Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Minamiku, Hiroshima 734, Japan

  Tomio Segawa

• Department of Pharmacology, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyoku Kyoto 602, Japan

  Kinya Kuriyama

• Departments of Pharmacology, Biochemistry, Psychiatry and the Arizona Research Laboratories, University of Arizona Health Sciences Center, Tucson, USA

  Henry I. Yamamura

• Department of Pharmacology, University of California, Los Angeles School of Medicine, Los Angeles, USA

  Richard W. Olsen

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