Myocardial Biology

1. Front Matter

   Pages i-xii

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2. Isolation of Canine Cardiac Sarcolemmal Vesicles

   • Larry R. Jones, Henry R. Besch Jr.

   Pages 1-12

3. Isolation of Sarcolemmal Membranes from Smooth Muscle

   • Mohammed A. Matlib

   Pages 13-24

4. Isolation of Cardiac Muscle Mitochondria: An Update

   • Mohammed A. Matlib, William Rouslin, Pal L. Vaghy, Arnold Schwartz

   Pages 25-37

5. Cardiac Sarcoplasmic Reticulum

   • Taitzer Wang, Jun Nakamura, Arnold Schwartz

   Pages 39-47

6. Methods for Measuring Functional Properties of Sarcoplasmic Reticulum and Myofibrils in Small Samples of Myocardium

   • Edward D. Pagani, R. John Solaro

   Pages 49-61

7. The Regulation of Free Ca2+ Ion Concentration by Metal Chelators

   • Steven Robertson, James D. Potter

   Pages 63-75

8. Study of Cardiac Autonomic Receptors by Radiolabeled Ligand Binding Assays

   • Allan S. Manalan, Larry R. Jones, Henry R. Besch Jr., August M. Watanabe

   Pages 77-94

9. Indicators of Calcium and Calcium Fluxes in Muscle, Its Subcellular Systems, and in Model Membranes

   • J. David Johnson, Denise E. Robinson, Laura A. Wittenauer, Douglas A. Fugman

   Pages 95-110

10. Isolated Heart Preparations Perfused or Superfused with Balanced Salt Solutions

    • Ingrid L. Grupp, Gunter Grupp

    Pages 111-128

11. Derived Indices of Myocardial Function in Isolated Work-Performing Hearts

    • Gunter Grupp

    Pages 129-139

12. Isolation and Characterization of Plasma Lipoproteins and Apolipoproteins

    • Alan D. Cardin, George Holdsworth, Richard L. Jackson

    Pages 141-166

13. Cardiac and Vascular Measurements in Conscious and Anesthetized Animals

    • R. W. Millard

    Pages 167-174

14. Applications of Nuclear Magnetic Resonance to the Study of Myocardial Metabolism and Pharmacology

    • P. M. Matthews, G. K. Radda

    Pages 175-228

15. Back Matter

    Pages 229-236

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It is a pleasure to introduce Volume 5 in the Methods in Pharmacology series. In 1971, Volume 1 of this series was published while I was Head of the Division of Myocardial Biology in the Department of Pharmacology at Baylor College of Medicine in Houston, Texas. I dedicated that first volume to Sir Henry Hallet Dale, who died on July 23, 1968. In the Preface I pointed out that many of the pharmacological advancements that occurred during the last century were direct descendants from the classic paper published in 1910 by Professor Dale and his colleague, Dr. Barger. In this paper, the concept of "specific receptor sites" was introduced by the statement that "the relationship of the recepted mechanism to the base [i. e. , drug base] may well be one of solid solution of adsorption and, therefore, more analogous to that of an enzyme to its substrate . . . . " I also pointed out at that time that the search for drug receptors continues and that fundamental knowledge of the nature of receptors and drug-receptor interaction will eventually lead to a rational approach to drug design. Since 1971, the study of receptors and their interaction with specific chemical substances has continued at an accelerated pace and this is due, in particular, to the introduction of new and exciting methodologies. The death last year of Professor Raymond P. Ahl­ quist, who pioneered the introduction of specific adrenergic receptors, represents the close of yet another era.

• drug
• lead
• pharmacology

• Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, USA

  Arnold Schwartz

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