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Immune Deficiency and Cancer

Epstein-Barr Virus and Lymphoproliferative Malignancies

  • Book
  • © 1984

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Editors:
  1. David T. Purtilo

    1. University of Nebraska Medical Center, Omaha, USA

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Immune Deficiency, Epstein-Barr Virus (EBV) and Lymphoproliferative Disorders

    1. Immune Deficiency, Epstein-Barr Virus (EBV) and Lymphoproliferative Disorders

      • David T. Purtilo
      Pages 1-10

  3. Classical Epstein-Barr Virus Associated Disorders

    1. Infectious Mononucleosis and Complications

      • James Linder, David T. Purtilo
      Pages 11-36

    2. Nasopharyngeal Carcinoma

      • Gerhard R. F. Krueger
      Pages 37-68

    3. Burkitt’s Lymphoma

      • James Linder, David T. Purtilo
      Pages 69-99

  4. Inherited Immune Deficiency and Lymphoproliferative Malignancies

    1. Hematopathology of X-Linked Lymphoproliferative Syndrome

      • David T. Purtilo
      Pages 101-122

    2. Responses to Epstein-Barr Virus in Immune Deficient Patients

      • Shinji Harada, Eiji Tatsumi, Helen Lipscomb, David T. Purtilo
      Pages 123-141

    3. Immunodeficiency to Epstein-Barr Virus in Chediak-Higashi Syndrome

      • Fernando Merino
      Pages 143-164

  6. Acquired Immune Deficiency and Lymphoproliferative Disorders

    1. Allograft Transplant cancer Registry

      • Israel Penn
      Pages 281-308

    2. Lymphoma in Cardiac Transplant Recipients Associated with Cyclosporin A, Prednisone and Anti-Thymocyte Globulin (ATG)

      • Charles P. Bieber, Richard L. Heberling, S. W. Jamieson, Phillip E. Oyer, Michael Cleary, Roger Warnke et al.
      Pages 309-320

    3. Lymphoproliferative Diseases in Renal Allograft Recipients

      • Douglas W. Hanto, Glauco Frizzera, Kazimiera J. Gajl-Peczalska, David T. Purtilo, Richard L. Simmons
      Pages 321-347

    4. Chronic Mononucleosis

      • Martin Tobi, Abraham Morag
      Pages 349-366

    5. The Syndrome of Acquired Immunodeficiency Among a Subset of Homosexual Men

      • Joseph A. Sonnabend, Steven S. Witkin, Ruth B. Purtilo, David T. Purtilo
      Pages 367-384

    6. Lymphoproliferative Diseases and Kaposi’s Sarcoma in Homosexual Males

      • Donald Abrams
      Pages 385-400
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Keywords

About this book

The discoveries of Burkitt, Epstein, and Henle have laid the foundation for continuing generation of information regarding the mechanisms of induction of diseases by Epstein-Barr virus. The discovery of the virus two decades ago resulted from clinical and basic science collaborative studies on Burkitt lymphoma. Subse­ quently, nasopharyngeal carcinoma and infectious mononucleosis have been linked etiologically with the virus. During the first decade of research following the discovery of the virus, the mechanisms for the induction of BL, NPC, and IM were sought. At that time one prevailing view was that individual oncogenic strains of EBV were responsible for the different disorders. Paralleling the development of immunology in the 1970's was the accrual of knowledge about immunological events occurring during IM. These studies suggest that immune defense mechanisms deter­ mine the outcome of this viral infection rather than different viral strains. During the early 1970's, Starzl and Penn and Gatti and Good had noted an increased frequency of malignancy in renal allograft recipients and children with primary immune deficiency disorders, respectively. These observations provoked investigators to restudy the role of immune surveillance against malignancy. At that time immune surveillance was thought to occur against tumor-specific antigens; thereby neoplasms were eliminated.

Editors and Affiliations

  • University of Nebraska Medical Center, Omaha, USA

    David T. Purtilo

Bibliographic Information

  • Book Title: Immune Deficiency and Cancer

  • Book Subtitle: Epstein-Barr Virus and Lymphoproliferative Malignancies

  • Editors: David T. Purtilo

  • DOI: https://doi.org/10.1007/978-1-4684-4760-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Publishing Corporation 1984

  • Softcover ISBN: 978-1-4684-4762-0Published: 22 March 2012

  • eBook ISBN: 978-1-4684-4760-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 488

  • Topics: Oncology

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