The Biology of Idiotypes

1. Front Matter

   Pages i-xv

   PDF

2. Molecular Genetic Aspects of Idiotypes

   1. Front Matter

      Pages 1-1

      PDF

   2. Idiotypic Determinants, Minigenes, and the Antibody Combining Site

      • Elvin A. Kabat

      Pages 3-17

   3. The Genes Encoding Anti-NP Antibodies in Inbred Strains of Mice

      • Alfred L. M. Bothwell

      Pages 19-34

   4. Structural and Genetic Basis of the Major Cross-Reactive Idiotype of the A Strain Mouse

      • Clive A. Slaughter, J. Donald Capra

      Pages 35-58

   5. The Molecular Genetics of Phosphocholine-Binding Antibodies

      • Roger M. Perlmutter

      Pages 59-74

   6. Genetic Rearrangements of Human Immunoglobulin Genes

      • Stanley J. Korsmeyer, Ajay Bakhshi, Andrew Arnold, Katherine A. Siminovitch, Thomas A. Waldmann

      Pages 75-95

   7. Analysis of the GAT B Repertoire

      • Michel Fougereau, José Rocca-Serra, Claudine Schiff, Cécile Tonnelle

      Pages 97-114

   8. Structural Correlates of Idiotypes Expressed on Galactan-Binding Antibodies

      • Stuart Rudikoff

      Pages 115-128

3. Serologic and Structural Correlates of Idiotypes

   1. Front Matter

      Pages 129-129

      PDF

   2. Idiotypic Markers and the Three-Dimensional Structure of Immunoglobulins

      • Roberto J. Poljak

      Pages 131-139

   3. Combining Site Specificity and Idiotypy

      • Edgar Haber, Michael N. Margolies

      Pages 141-170

   4. The Murine Antibody Response to Phosphocholine

      • J. Latham Claflin, Jacqueline Wolfe, Anne Maddalena, Susan Hudak

      Pages 171-195

   5. The Limiting Dilution Approach to the Analysis of the Idiotypic Repertoire

      • Daniélé Primi, Dominique Juy, Pierre-André Cazenave

      Pages 197-212

   6. Antibody Diversity in the Response to Streptococcal Group A Carbohydrate

      • R. Jerrold Fulton, Moon H. Nahm, Neil S. Greenspan, Joseph M. Davie

      Pages 213-223

   7. Idiotypes of Ir Gene-Controlled Anti-GAT Response

      • Shyr-Te Ju

      Pages 225-236

   8. Cross-Reacting Idiotypes in the Human System

      • Henry G. Kunkel

      Pages 237-246

4. Regulation of Idiotypes

   1. Front Matter

      Pages 247-247

      PDF

   2. Genetic and Environmental Control of B-Cell Idiotype Expression

      • Dorith Zharhary, Richard L. Riley, Barbara G. Froscher, Norman R. Klinman

      Pages 249-259

   3. Quantitative Estimates of Diversity, Degeneracy, and Connectivity in an Idiotypic Network among T Cells

      • K. Fey, M. M. Simon, I. Melchers, K. Eichmann

      Pages 261-277

The phenomenon of idiotypy was discovered almost thirty years ago, but it was only during the past decade that it attracted widespread interest and became the subject of numerous research investigations. From the outset, much of the interest in idiotypy was based on its implications with respect to the repertoire of antibodies. Kunkel showed, for example, that idiotypes associated with certain human myeloma or Bence-Jones proteins were present in normal human globulins at levels of less than one part per million. Also, Oudin's original definition of idiotypy implied that idiotypes could be uniquely associated with individual rabbits as well as with particular antigen-binding specificities. Such observations provided some of the earliest evidence for an extensive repertoire of immunoglobulin molecules. The implications of these findings have been amply confirmed by recent studies of protein struc­ ture and molecular genetics; many of these studies are reviewed in the present volume. It is known now that the diversity of antibodies is based on the presence of numerous V and L V H genes, on recombinatorial events involving D and] segments, on somatic mutations, and on processes involving deletion of DNA followed by repair with errors, including inser­ tions. Each of these parameters is capable of influencing the idiotype expressed by the final immunoglobulin product. Regulation of the immune response is another area in which idiotypy has significantly influenced modern immunology.

• antibody
• antigen
• genetics
• immune response
• immunoglobulin
• immunology
• molecular genetics
• proteins

• Department of Pathology, Harvard Medical School, Boston, USA

  Mark I. Greene

• Rosenstiel Research Center, Brandeis University, Waltham, USA

  Alfred Nisonoff

Policies and ethics