Monoclonal Antibodies and Functional Cell Lines

1. Front Matter

   Pages i-xvii

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Introduction

      • Roger H. Kennett, Kathleen B. Bechtol, Thomas J. McKearn

      Pages 3-14

3. Characterization of the Detailed Antigenic Structure of Macromolecules

   1. Front Matter

      Pages 15-15

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   2. Monoclonal Antibodies Directed against the Nicotinic Acetylcholine Receptor

      • David P. Richman

      Pages 17-31

   3. Monoclonal Antibodies to Enzymes

      • Harry Harris

      Pages 33-65

   4. Monoclonal Antibodies Directed to Cell-Surface Carbohydrates

      • Sen-Itiroh Hakomori

      Pages 67-100

4. Detection and Isolation of Antigens in Complex Biological Systems

   1. Front Matter

      Pages 101-101

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   2. Adhesion-Related Integral Membrane Glycoproteins Identified by Monoclonal Antibodies

      • Alan F. Horwitz, Karen A. Knudsen, Caroline H. Damsky, Cindi Decker, Clayton A. Buck, Nicola T. Neff

      Pages 103-118

   3. Monoclonal Antibodies to Cytoskeletal Proteins

      • J. J. C. Lin, J. R. Feramisco, S. H. Blose, F. Matsumura

      Pages 119-151

   4. Molecular Bases of Neuronal Individuality

      • Lois Alterman Lampson

      Pages 153-189

5. Toward Practical Applications in Medicine

   1. Front Matter

      Pages 191-191

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   2. Monoclonal Antibodies to Human Lymphocytes

      • Ronald Levy, Paul Stratte, Michael Link, David G. Maloney, Alan Oseroff, Richard A. Miller

      Pages 193-214

   3. Monoclonal Antibodies to Human Neuroblastoma Cells and Other Solid Tumors

      • Frank Berthold

      Pages 215-237

   4. Monoclonal Antibodies and Immunoparasitology

      • S. Michael Phillips, Deni M. Zodda

      Pages 239-272

6. Developing Areas of Biotechnology

   1. Front Matter

      Pages 273-273

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   2. Production of Human Monoclonal Antibodies

      • David W. Buck, James W. Larrick, Andrew Raubitschek, Kenneth E. Truitt, G. Senyk, J. Wang et al.

      Pages 275-309

   3. Monoclonal Antibodies and Molecular Genetics

      • Roger H. Kennett, Zdenka L. Jonak, Naohiko Ikegaki

      Pages 311-340

   4. Functional Murine T-Cell Clones

      • Frank W. Fitch, Andrew L. Glasebrook

      Pages 341-363

7. Back Matter

   Pages 365-426

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This volume serves as a follow-up to our previous book, MonoclonalAntibodies­ Hybridomas: A New Dimension in Biological Analyses. We continue the theme of monoclonal antibodies and their applications, attempting to cover some of the areas not covered in the previous volume. We again include an appendix de­ scribing methods useful to those who ar-e beginning to apply these techniques in their own laboratories. This volume will be followed by another concentrating on the combination of monoclonal antibody techniques with molecular genetic techniques to study structure/function relationships at the level of both the gene and gene product. Roger H. Kennett Kathleen B. Bechtol Philadelphia, Pennsylvania Thomas J. McKearn Princeton, New Jersey IX Acknowledgments Roger Kennett acknowledges the patience and support of his wife, Carol, and his family, friends, and colleagues during the work on this volume, and again thanks, above all, the Lord, Jesus Christ. Kathleen Bechtol wishes to thank colleagues and friends for their support and understanding during the months of preparation of this volume. Tom McKearn acknowledges and thanks his wife, Pat, and his family for their support and encouragement. Xl Contents PART I INTRODUCTION 1 Introduction: Reflections on Nine Years of Monoclonal Antibodies from Hybridomas 3 ROGER H. KENNETT, KATHLEEN B. BECHTOL, AND THOMAS J. McKEARN 1. Biotechnology'S "Coming of Age". . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 II. Monoclonal Antibodies-An Overview of Applications. . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 III. Commercialization of Monoclonal Antibody Technology.. . . .. ... . .... .... .. . ... . . 10 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . 13 . . . . . . . . . . . . . . . . . . . . .

• antibody
• antigen
• diseases
• gene
• genetics
• immunization
• immunoglobulin
• leukemia
• lymphocytes
• medicine
• molecular genetics
• parasite
• parasitology
• proteins
• tissue
• antibodies

• University of Pennsylvania School of Medicine, Philadelphia, USA

  Roger H. Kennett

• The Wistar Institute of Anatomy and Biology, Philadelphia, USA

  Kathleen B. Bechtol

• Cytogen Corporation, Princeton, USA

  Thomas J. McKearn

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