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Genotoxicology of N-Nitroso Compounds

  • Book
  • © 1984

Overview

Editors:
  1. T. K. Rao

    1. Environmental Health Research and Testing, Inc., Research Triangle Park, USA
      Biology Division, Oak Ridge National Laboratory, Oak Ridge, USA

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  2. W. Lijinsky

    1. Chemical Carcinogenesis Program, NCI-Frederick Cancer Research Facility, Frederick, USA

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  3. J. L. Epler

    1. Biology Division, Oak Ridge National Laboratory, Oak Ridge, USA

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Part of the book series: Topics in Chemical Mutagenesis (TCM)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Formation of N-Nitroso Compounds and Their Significance

    • William Lijinsky
    Pages 1-11

  3. N-Nitrosamine Mutagenicity Using the Salmonella/Mammalian-Microsome Mutagenicity Assay

    • A. W. Andrews, W. Lijinsky
    Pages 13-43

  4. Structural Basis for Mutagenic Activity of N-Nitrosamines in the Salmonella Histidine Reversion Assay

    • T. K. Rao
    Pages 45-58

  5. Effects of pH and Structure on the Mutagenic Activity of N-Nitroso Compounds

    • Joseph B. Guttenplan
    Pages 59-90

  6. Induction of Bacteriophage Lambda by N-Nitroso Compounds

    • Rosalie K. Elespuru
    Pages 91-118

  7. The Relationship between the Carcinogenicity and Mutagenicity of Nitrosamines in a Hepatocyte-Mediated Mutagenicity Assay

    • Carol A. Jones, Eliezer Huberman
    Pages 119-127

  8. Mutagenic Activity of Nitrosamines in Mammalian Cells

    • Ti Ho, Juan R. San Sebastian, Abraham W. Hsie
    Pages 129-147

  9. Dimethylnitrosamine Demethylase and the Mutagenicity of Dimethylnitrosamine

    • Michael J. Prival, Valerie D. Mitchell
    Pages 149-165

  10. The Relationship between Metabolism and Mutagenicity of Two Cyclic Nitrosamines

    • James G. Farrelly, Lanny I. Hecker
    Pages 167-187

  11. Structure-Activity Relations in Carcinogenesis by N-Nitroso Compounds

    • William Lijinsky
    Pages 189-231

  12. Comparison of Mutagenic and Carcinogenic Properties

    • W. Lijinsky, J. L. Epler, T. K. Rao
    Pages 233-263

  13. Back Matter

    Pages 265-271
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Keywords

About this book

Toph's in Chemical Mutagenesis is a new series dedicated to studies in the areas of environmental chemical mutagenesis and genetic toxicology. In this series we will explore some of many topics that are emerging in these rapidly developing fields. The purpose of the present volume is to attempt to organize and compare the genotoxic properties of the N-nitroso compounds. This is a particularly interesting class of compounds because of the problems encountered with the Salmonella assay of Ames in generating both false positive and false negative results. The battery approach using a number of assay systems seems more appropriate to evaluate chemicals in this class. Topics to be discussed in other volumes in this series include single-cell mutation monitoring systems, the detection of genetic damage in mammalian germ cells, the mutagenicity of pesticides, problems in monitoring human populations in genetic toxicology, and a glossary of terms in genetic toxicology. All of these books are in various stages of development and should appear within the next few years. Frederick J. de Serres Series Editor vii Preface During the past ten years there has been an explosive development in the number of short-term tests to predict the biological risks, especially risks of cancer, in exposure to xenobiotic chemicals. The number of published articles in this area has reached many thousands a year and there are several new journals devoted almost entirely to the presentation of the results obtained in these tests.

Editors and Affiliations

  • Environmental Health Research and Testing, Inc., Research Triangle Park, USA

    T. K. Rao

  • Biology Division, Oak Ridge National Laboratory, Oak Ridge, USA

    T. K. Rao, J. L. Epler

  • Chemical Carcinogenesis Program, NCI-Frederick Cancer Research Facility, Frederick, USA

    W. Lijinsky

Bibliographic Information

  • Book Title: Genotoxicology of N-Nitroso Compounds

  • Editors: T. K. Rao, W. Lijinsky, J. L. Epler

  • Series Title: Topics in Chemical Mutagenesis

  • DOI: https://doi.org/10.1007/978-1-4684-4595-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1984

  • Softcover ISBN: 978-1-4684-4597-8Published: 29 April 2012

  • eBook ISBN: 978-1-4684-4595-4Published: 11 November 2013

  • Edition Number: 1

  • Number of Pages: XVI, 271

  • Number of Illustrations: 24 b/w illustrations

  • Topics: Veterinary Medicine/Veterinary Science

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