Immunobiology of Parasites and Parasitic Infections

1. Front Matter

   Pages i-xx

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2. Natural Resistance to Animal Parasites

   • Joseph F. Albright, Julia W. Albright

   Pages 1-52

3. Intracellular Mechanisms of Killing

   • Nadia Nogueira

   Pages 53-69

4. Induction and Expression of Mucosal Immune Responses and Inflammation to Parasitic Infections

   • Dean Befus, John Bienenstock

   Pages 71-108

5. Antigenic Characterization of Plasmodia

   • Luc H. Perrin, L. Rodriguez da Silva, R. Dayal

   Pages 109-125

6. Roles of Surface Antigens on Malaria-Infected Red Blood Cells in Evasion of Immunity

   • Russell J. Howard, John W. Barnwell

   Pages 127-200

7. Murine T-Cell Responses to Protozoan and Metazoan Parasites: Functional Analysis of T-Cell Lines and Clones Specific for Leishmania tropica and Schistosoma mansoni

   • J. A. Louis, G. Lima, J. Pestel, R. Titus, H. D. Engers

   Pages 201-224

8. Immunobiology of African Trypanosomiasis

   • Georges E. Roelants, Margaret Pinder

   Pages 225-274

9. Rodent Models of Filariasis

   • Mario Philipp, M. J. Worms, R. M. Maizels, Bridget M. Ogilvie

   Pages 275-321

10. Examination of Strategies for Vaccination against Parasitic Infection or Disease Using Mouse Models

    • Graham F. Mitchell, Robin F. Anders, Colin B. Chapman, Ian C. Roberts-Thomson, Emanuela Handman, Kathy M. Cruise et al.

    Pages 323-358

11. Immunity in Schistosomiasis: A Holistic View

    • Raymond T. Damian

    Pages 359-420

12. Immunopathology of Parasitic Diseases: A Conceptual Approach

    • S. Michael Phillips, Edward G. Fox

    Pages 421-461

13. Cellular Immunity to Malaria and Babesia Parasites: A Personal Viewpoint

    • Anthony C. Allison

    Pages 463-490

14. Back Matter

    Pages 491-497

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The phenomena involved in infections of man and domestic animals with metazoan or protozoan parasites present formidable practical problems as well as a theoretical challenge to immunologists, molecular biologists, and evolu­ tionary biologists. With respect to the public health and economic problems, malaria, for example, remains a major health problem with approximately 200 million people being infected yearly and, on the basis of World Health Organiza­ tion estimates, more than 1 million children die each year of malaria infections (Chapter 4). This volume addresses state-of-the-art immunologic approaches to the development of vaccines for parasitic diseases (Chapter 9) and analyses of studies bearing on the antigenic characterization of protozoan and metazoan parasites (Chapters 4, 5, and 7), on investigations of the role of precise mecha­ nisms underlying natural resistance or non permissiveness of the host to parasitic infections (Chapters 1, 2, and 12), on induced mechanisms including the genera­ tion of parasite-specific T-cell lines and clones (Chapter 6), and on the generation of monoclonal antibodies (Chapters 4 and 5) to parasite antigens of distinct de­ velopmental stages. Great progress has been made in characterizing parasite antigens capable of inducing a protective response in the vaccinated host; further progress in this area strongly depends on biochemistry and molecular biology with the long-term goal of synthesizing such antigens chemically or producing them by means of recombinant DNA technology (Chapter 4).

• DNA
• antibody
• antigen
• biochemistry
• biology
• diseases
• immunobiology
• infection
• infections
• malaria
• molecular biology
• parasite
• protozoa
• resistance
• vaccine

• Medical University of South Carolina, Charleston, USA

  John J. Marchalonis

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