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Drug Metabolite Isolation and Determination

  • Book
  • © 1983

Overview

Editors:
  1. Eric Reid

    1. University of Surrey, UK

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  2. J. P. Leppard

    1. University of Surrey, UK

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Methodological Surveys in Biochemistry and Analysis (MSBA, volume 12)

Part of the book sub series: A: Analysis (ANAY)

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-xii
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  3. NOTES and COMMENTS relating to Techniques applicable to metabolite investigation

    1. Front Matter

      Pages 63-63
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    2. A Note on TLC Densitometry for Drug and Metabolite Determination

      • D. A. Stopher
      Pages 65-67

    3. A Note on Taking Aliquots from Small Volumes of Upper Phases

      • H. de Bree
      Pages 69-69

    4. A Note on Rapid Removal of Fine Particles from Alumina for Column Chromatography

      • B. L. Goodwin
      Pages 71-73

    5. A Note on Assessment of Radioactivity Measurements on HPLC Effluents

      • B. F. H. Drenth, T. Jagersma, F. Overzet, R. T. Ghijsen, R. A. de Zeeuw
      Pages 75-80

    6. A Note on Quantitation of14C Radioactivity in HPLC Eluates

      • D. W. Roberts
      Pages 81-88

  4. Investigation of Metabolites, Especially Phase I

    1. Front Matter

      Pages 95-95
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    2. Examples of Approaches to Isolating and Identifying Phase I Metabolites

      • G. R. Bourne, S. R. Moss
      Pages 97-102

    3. The Identification of Amitriptyline and Benzodiazepine Metabolites

      • Ian D. Watson, David R. Jarvie, Anne Chambers, Michael J. Stewart
      Pages 103-110

    4. A Novel Use of RIA and HPLC in the Identification of Plasma Metabolites of HR 158

      • J. D. Robinson, I. D. Wilson, C. D. Bevan, J. Chamberlain
      Pages 111-118

    5. Investigation of Pesticide Metabolites in the Human

      • C. V. Eadsforth
      Pages 119-133
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Keywords

About this book

Scope of the book, and acknowledgements.- The articles are focused on 'real problems' in body-fluid analysis, typically with a final chromatographic separation of ~g or often ng amounts if the aim is quantitation. The pitfalls may not be realized by a typical chemist (cf. remarks in #A-3), but he may excel in metabolite iden­ tification - which this book covers to a fair extent. Where identity is known, and the metabolite could interfere in therapeutic drug monitoring or in diagnosis or itself have clinical relevance, useful guidance will come from articles that follow. Authors have gone to much trouble, and are not to be blamed by any reader who would have liked an introduction to chromatography or to metabolic pathways (cf. list of conjugation reactions at end of concluding article). Appre­ ciation is also expressed for permission to reproduce published mat­ erial; the acknowledged sources include 1. Chroma tog. (Elsevier; e. g. in #A-l) , Anal. Chem. (American Chemical Society; #A-2) and Wiley.

Editors and Affiliations

  • University of Surrey, UK

    Eric Reid, J. P. Leppard

Bibliographic Information

  • Book Title: Drug Metabolite Isolation and Determination

  • Editors: Eric Reid, J. P. Leppard

  • Series Title: Methodological Surveys in Biochemistry and Analysis

  • DOI: https://doi.org/10.1007/978-1-4684-4484-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1983

  • Softcover ISBN: 978-1-4684-4486-5Published: 26 November 2012

  • eBook ISBN: 978-1-4684-4484-1Published: 08 March 2013

  • Edition Number: 1

  • Number of Pages: XII, 290

  • Number of Illustrations: 5 b/w illustrations

  • Topics: Physical Chemistry

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