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Host Defenses to Intracellular Pathogens

Proceedings of a conference held in Philadelphia, Pennsylvania, June 10-12, 1981

  • Conference proceedings
  • © 1983

Overview

Editors:
  1. Toby K. Eisenstein

    1. Temple University School of Medicine, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Paul Actor

    1. Smith, Kline, and French Laboratories, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Herman Friedman

    1. College of Medicine, University of South Florida, Tampa, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 162)

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Table of contents (48 papers)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Introduction and Historical Perspective

    1. Introduction and Historical Perspective

      • Toby K. Eisenstein
      Pages 1-4

  3. Microbicidal Mechanisms of Leukocytes in Host Defenses

    1. Oxygen Independent Microbicidal Mechanisms of Human Polymorphonuclear Leukocytes

      • John K. Spitznagel, Noburu Okamura
      Pages 5-17

    2. Oxidative Metabolism of Leukocytes and Its Relationship to Bactericidal Activity

      • Lawrence R. DeChatelet, Pamela S. Shirley, Linda C. McPhail
      Pages 19-30

    3. Some Paradoxes of Macrophage Function

      • Mayer B. Goren
      Pages 31-50

    4. Genetic Disorders of Granulocyte Function: What they Tell Us about Normal Mechanisms

      • Richard K. Root
      Pages 51-59

  4. The Immune System and Phagocytic Cell Function

    1. Modulation of Effector Lymphokines

      • Stanley Cohen, Tohru Baba, Matsunobu Suko, Helen D’Silva, Takeshi Yoshida
      Pages 61-68

    2. Stimulation of Host Resistance to Metastatic Tumors by Macrophage Activating Agents Encapsulated in Liposomes

      • Richard Kirsh, George Poste
      Pages 69-75

    3. Effect of Prostaglandins on the Production of Interleukin-2

      • R. S. Rappaport, G. R. Dodge
      Pages 77-82

    4. Interaction of Mycobacteria with Normal and Immunologically Activated Alveolar Macrophages

      • Quentin N. Myrvik, Eva S. Leake, Klara Tenner-Racz
      Pages 83-98

    5. Guinea Pig Alveolar Macrophages Probably Kill M. Tuberculosis H37Rv and H37Ra In Vivo by Producing Hydrogen Peroxide

      • P. S. Jackett, P. W. Andrew, V. R. Aber, D. B. Lowrie
      Pages 99-104

    6. Interferon and Host Defense Systems

      • Howard M. Johnson
      Pages 105-119

    7. Mediator Interactions Regulating Macrophage Secretion of Interleukin 1 and Interferon

      • Robert N. Moore, Patricia S. Steeg, Stephan E. Mergenhagen
      Pages 121-126

    8. Macrophage Oxygen-Dependent Killing of Intracellular Parasites: Toxoplasma and Leishmania

      • Henry W. Murray
      Pages 127-143

    9. Immunologic Lesions During Toxoplasma Gondii Infection

      • Edmond A. Goidl, Urban Ramstedt, Thomas C. Jones
      Pages 145-150

    10. Immunodepression in BALB/c Mice Infected with Leishmania Tropica

      • Phillip A. Scott, Jay P. Farrell
      Pages 151-155

  5. Host Defenses to Intracellular Bacteria

    1. Cellular Mechanisms of Anti-Mycobacterial Immunity

      • Frank M. Collins
      Pages 157-182

    2. Host Response to Infection with Mycobacterium Bovis (BCG) in Mice: Genetic Study of Natural Resistance

      • Philippe Gros, Emil Skamene, Adrien Forget, Ben Taylor
      Pages 183-188

    3. Cell Mediated Lysis of Lymphocytes Expressing Bacterial Antigens

      • J. A. Hank, P. M. Sondel
      Pages 189-195

    4. Improvement of Abnormal Lymphocyte Responses in “Atypical” Mycobacteriosis with Indomethacin

      • U. G. Mason III, L. E. Greenberg, S. S. Yen, C. H. Kirkpatrick
      Pages 197-201
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Keywords

About this book

The subject matter of this volume was the basis for a confer­ ence held in Philadelphia in June, 1981, and is an important one in the contemporary area of how the host interacts with micro­ organisms. In conception, it grew out of a graduate course entitled, "The Infectious Process," which has been taught in the Department of Microbiology and Immunology at Temple University School of Medicine during the past twelve years. This course has explored the broad areas of mechanisms of microbial pathogenesis and host resistance by in-depth consideration of selected models of experimental infection and immunity, as well as the clinical literature. It is noteworthy that there is no adequate text for this material, as the subject matter naturally crosses a wide spectrum of traditional disciplinary lines, encompassing topics as diverse as the mechanisms of action of bacterial toxins, the role of complement and antibody in phagocytosis, and the importance of cross-reacting bacterial polysaccharide antigens in vaccine development. A major portion of the course has always considered "cellular immunity" as it applies to host defenses to intracellular pathogens. It is in this area that the necessity for amalgamation of information from different disciplines is most evident, for one must be intimately concerned with the interactions between the microbe and the phagocyte, both before and after specific immune recognition.

Editors and Affiliations

  • Temple University School of Medicine, Philadelphia, USA

    Toby K. Eisenstein

  • Smith, Kline, and French Laboratories, Philadelphia, USA

    Paul Actor

  • College of Medicine, University of South Florida, Tampa, USA

    Herman Friedman

Bibliographic Information

  • Book Title: Host Defenses to Intracellular Pathogens

  • Book Subtitle: Proceedings of a conference held in Philadelphia, Pennsylvania, June 10-12, 1981

  • Editors: Toby K. Eisenstein, Paul Actor, Herman Friedman

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-4481-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1983

  • Softcover ISBN: 978-1-4684-4483-4Published: 25 February 2012

  • eBook ISBN: 978-1-4684-4481-0Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XV, 538

  • Topics: Cell Biology, Immunology, Microbiology

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