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Organ and Species Specificity in Chemical Carcinogenesis

  • Book
  • © 1983

Overview

Editors:
  1. Robert Langenbach

    1. U.S. Environmental Protection Agency, Research Triangle Park, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Stephen Nesnow

    1. U.S. Environmental Protection Agency, Research Triangle Park, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Jerry M. Rice

    1. National Cancer Institute, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Basic Life Sciences (BLSC, volume 24)

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Table of contents (35 chapters)

  1. Front Matter

    Pages i-ix
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  2. The Nature of Organ Specificity in Chemical Carcinogenesis

    • Jerry M. Rice, Charles H. Frith
    Pages 1-22

  3. Species Differences in Response to Aromatic Amines

    • Elizabeth K. Weisburger
    Pages 23-47

  4. Aflatoxin B1: Correlations of Patterns of Metabolism and DNA Modification with Biological Effects

    • Robert G. Croy, John M. Essigmann, Gerald N. Wogan
    Pages 49-62

  5. Species Specificity in Nitrosamine Carcinogenesis

    • William Lijinsky
    Pages 63-75

  6. Organ Specificity and Interspecies Differences in Carcinogenesis by Metabolism-Independent Alkylating Agents

    • Jerry M. Rice, Alan Perantoni
    Pages 77-105

  7. Organ and Species Specificity in Nickel Subsulfide Carcinogenesis

    • F. William Sunderman Jr.
    Pages 107-127

  8. Chemical Carcinogenesis Studies in Nonhuman Primates

    • R. H. Adamson, S. M. Sieber
    Pages 129-156

  9. Organ Specificity and Tumor Promotion

    • Stuart H. Yuspa, Henry Hennings, Ulrike Lichti, Molly Kulesz-Martin
    Pages 157-171

  10. Skin Tumor Promotion: A Comparative Study of Several Stocks and Strains of Mice

    • John Reiners Jr., Kowetha Davidson, Kay Nelson, Mark Mamrack, Thomas Slaga
    Pages 173-188

  11. The Role of Phorbol Ester Receptor Binding in Responses to Promoters by Mouse and Human Cells

    • N. H. Colburn, T. D. Gindhart, B. Dalal, G. A. Hegamyer
    Pages 189-200

  12. Tissue and Species Specificity for Phorbol Ester Receptors

    • Peter M. Blumberg, K. Barry Delclos, Susan Jaken
    Pages 201-229

  13. Liver as a Model System for Analyzing Mechanisms of Tumor Initiation and Promotion

    • Fred J. Stevens, Carl Peraino
    Pages 231-252

  14. Promotion of Urinary Bladder Carcinogenesis

    • Samuel M. Cohen
    Pages 253-272

  15. Species and Organ Differences in the Biotransformation of Chemical Carcinogens

    • Mont R. Juchau
    Pages 273-281

  16. Species Heterogeneity in the Metabolic Processing of Benzo[a]pyrene

    • James K. Selkirk, Michael C. MacLeod, Betty K. Mansfield, Patsy A. Nikbakht, Kris C. Dearstone
    Pages 283-294

  17. Endocrine Regulation of Xenobiotic Conjugation Enzymes

    • Coral A. Lamartiniere, George W. Lucier
    Pages 295-312

  18. Multiple Effects and Metabolism of α-Naphthoflavone in Induced and Uninduced Hepatic Microsomes

    • Stephen Nesnow
    Pages 313-329

  19. Species Differences in the Activation of Benzo[a]pyrene in the Tracheal Epithelium of Rats and Hamsters

    • Marc J. Mass, David G. Kaufman
    Pages 331-351

  20. Subcellular Metabolic Activation Systems: Their Utility and Limitations in Predicting Organ and Species Specific Carcinogenesis of Chemicals

    • Helmut Bartsch, Christian Malaveille, Anne-Marie Camus
    Pages 353-375
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About this book

The Symposium on Organ and Species Specificity in Chemical Carcinogenesis was held March 1981 in Raleigh, North Carolina. Dr. James Miller concluded this Symposium with these remarks: "Without a doubt all of us would agree this has been a very successful symposium in illustrating a very wide range of chemical, stereochemical, biochemical, metabolic, molecular, and biological factors in chemical carcinogenesis. I think it is noteworthy that many of the discussions have dealt with pharmacodynamic, or toxicodynamic, factors that can influence the biological activities of the extremely wide range of structures that we choose to call chemical carcinogens. I sincerely hope that after this symposium everyone here will realize the very great need we have for further information on these agents in the species we profess to be working for, the human species. We badly need an adequate data base on human organs, human tissues, human cells, human subcellular preparations, and human body fluids. I don't think we can rely on extrapolations of data on chemical carcinogenesis from experimental animals to humans, no matter how sophisticated or plausible these extrapolations may seem, until we know far more about chemical carcinogenesis in humans. Now, I'd like to add a somewhat personal note. As many of you know, my wife and I have shared a joint career of some 40 years in this field, and I'd like to emphasize in these closing remarks the factor of youth.

Editors and Affiliations

  • U.S. Environmental Protection Agency, Research Triangle Park, USA

    Robert Langenbach, Stephen Nesnow

  • National Cancer Institute, Bethesda, USA

    Jerry M. Rice

Bibliographic Information

  • Book Title: Organ and Species Specificity in Chemical Carcinogenesis

  • Editors: Robert Langenbach, Stephen Nesnow, Jerry M. Rice

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4684-4400-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1983

  • Softcover ISBN: 978-1-4684-4402-5Published: 24 April 2012

  • eBook ISBN: 978-1-4684-4400-1Published: 21 November 2013

  • Edition Number: 1

  • Number of Pages: IX, 693

  • Topics: Veterinary Medicine/Veterinary Science

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