Factors in Formation and Regression of the Atherosclerotic Plaque

1. Front Matter

   Pages i-viii

   PDF

2. Physiology and Pathology of the Arterial Wall

   1. Morphology and Physiology of the Arterial Wall

      • Giorgio Weber

      Pages 1-19

   2. Metabolism of the Arterial Wall

      • Elspeth B. Smith

      Pages 21-33

   3. Aortic Lipid Metabolism

      • David Kritchevsky

      Pages 35-43

   4. From the Fatty Streak to the Calcified Lesion

      • Elspeth B. Smith

      Pages 45-57

   5. Progression and Regression of Advanced Atherosclerosis as Studied by Quantitative Methods

      • Robert W. Wissler

      Pages 59-78

   6. Ultrasound Techniques in the Study of Carotid Artery Atheroma

      • Robert J. Lusby

      Pages 79-93

3. Animal Models

   1. Experimental Atherosclerosis: Diet and Drugs

      • David Kritchevsky

      Pages 95-105

   2. On the Selection of Animal Species as Models for Atherosclerosis Research, with Particular Reference to the Common Marmoset (Callithrix Jacchus)

      • M. John Chapman, Patricia Forgez, Sonia Goldstein, Fergus McTaggart

      Pages 107-114

4. Lipoproteins and Atherosclerosis

   1. Smooth Muscle Metabolic Reactivity in Atherogenesis: LDL Metabolism and Response to Serum Mitogens Differ According to Phenotype

      • Julie H. Chamley-Campbell, Paul Nestel, Gordon R. Campbell

      Pages 115-123

   2. Thermodynamics and Mechanism of the Association of Plasma Apolipoproteins with Synthetic Phosphatidylcholines

      • H. J. Pownall, J. B. Massey, A. M. Gotto Jr.

      Pages 125-137

   3. Metabolic Fate of 3H-Cholesteryl Linoleyl Ether, a Nondegradable Analog of Lipoprotein Cholesteryl Ester

      • Yechezkiel Stein, Olga Stein, Gideon Halperin

      Pages 139-153

   4. Interactions Between Lipoproteins and Glycosaminoglycans

      • A. L. Catapano, E. Trezzi, R. Fumagalli

      Pages 155-161

   5. Plasma Lipoprotein Changes Induced by Diets and Drugs

      • Cesare R. Sirtori

      Pages 163-195

5. Platelets and Atherosclerosis

   1. Endogenous Agents in Platelet Thrombosis

      • G. V. R. Born, M. A. A. Kratzer

      Pages 197-207

   2. Platelet and Vascular Prostaglandins in Uraemia, Thrombotic Microangiopathy and Pre-Eclampsia

      • G. de Gaetano, M. Livio, M. B. Donati, G. Remuzzi

      Pages 209-215

   3. Pharmacological and Dietary Control of Platelet Vessel Wall Inter-Actions in Normal and Pathological Conditions

      • E. Tremoli, C. Galli, R. Paoletti

      Pages 217-241

6. Other Factors in Progression and Regression

   1. Tobacco Smoking and Atherosclerosis

      • Constantin J. Miras

      Pages 243-253

   2. Ethanol and Blood Lipids in Man

      • P. Avogaro, G. Bittolo-Bon, F. Belussi, G. Cazzolato

      Pages 255-262

7. Back Matter

   Pages 263-266

   PDF

Interest in the field of atherosclerosis research has broadened in recent years. However the main focus remains on the physiopathology of the arterial wall and on its interaction with blood constituents. The purpose of this NATO Advanced Study Institute on "Factors in Formation and Regression of the Atherosclerotic Plaque" was to discuss the following points: a) The physiopathology of the arterial wall; b) Animal models; c) Methods of studying the progression and regression of atherosclerotic lesions quantitatively; d) The role of lipoproteins, platelets, smoke, alcohol, etc. in the formation of atherosclerotic lesions; e) The pharmacological and dietary control of "risk factors." This volume is a collection of the most relevant presentations on these topics. We hope it will provide a background for young scientists as well as a stimulus for further research to biologists and clinicians. We wish to acknowledge the support of NATO and the Nutrition Foundation of Italy in organizing this Advanced Study Institute.

• Lipoprotein
• atherosclerosis
• nutrition
• pathology
• protein

• University of London King’s College, London, England

  Gustav R. V. Born

• Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy

  Alberico L. Catapano, Rodolfo Paoletti

Policies and ethics