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Targeting of Drugs

  • Book
  • © 1982

Overview

Editors:
  1. Gregory Gregoriadis

    1. Clinical Research Centre, Harrow, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. Judith Senior

    1. Clinical Research Centre, Harrow, UK

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    You can also search for this editor in PubMed   Google Scholar

  3. André Trouet

    1. International Institute of Cellular and Molecular Pathology, Brussels, Belgium

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Series A: (NSSA, volume 47)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Macromolecular Carriers

    1. Hepatocyte Targeting of Antiviral Drugs Coupled to Galactosyl-Terminating Glycoproteins

      • L. Fiume, C. Busi, A. Mattioli, P. G. Balboni, G. Barbanti-Brodano, Th Wieland
      Pages 1-17

    2. Targeting of Antitumour and Antiprotozoal Drugs by Covalent Linkage to Protein Carriers

      • AndrĂ© Trouet, Roger Baurain, Danièle Deprez-De Campeneere, Michèle Masquelier, Philippe Pirson
      Pages 19-30

    3. Antibodies and Dextran as Anti-Tumour Drug Carriers

      • Ruth Arnon
      Pages 31-54

    4. Targeting of Radionuclides and Drugs for the Diagnosis and Treatment of Cancer

      • T. Ghose, H. Blair, P. Kulkarni, K. Vaughan, S. Norvell, P. Belitsky
      Pages 55-82

    5. Antibody-Toxin Conjugates as Potential Therapeutic Agents

      • D. Caird Edwards, Philip E. Thorpe, Anthony J. S. Davies
      Pages 83-96

    6. Selectivity in Cancer Chemotherapy

      • T. A. Connors
      Pages 97-107

  3. Particulate and Cellular Carriers

    1. Drug Conjugates of Polymeric Microspheres as Tools in Cell Biology

      • I. Pecht, N. Mazurek, A. Petrank, S. Margel
      Pages 109-124

    2. Reconstituted Sendai Virus Envelopes as a Vehicle for the Introduction of Soluble Macromolecules and Membrane Components into Animal Cells

      • M. Beigel, G. Eytan, A. Loyter
      Pages 125-143

    3. Erythrocytes as Carriers for Recombinant Cloned DNA

      • Garret M. Ihler
      Pages 145-153

  4. Liposomal Carriers

    1. Targeting of Liposomes: Study of Influencing Factors

      • Gregory Gregoriadis, Christopher Kirby, Pamela Large, Anne Meehan, Judith Senior
      Pages 155-184

    2. Antibody-Mediated Targeting of Liposomes

      • John N. Weinstein, Lee D. Leserman, Pierre A. Henkart, Robert Blumenthal
      Pages 185-202

    3. Delivery of Drugs in Temperature-Sensitive Liposomes

      • R. L. Magin, J. N. Weinstein
      Pages 203-221

    4. Hyperthermia-Mediated Targeting of Liposome-Associated Anti-Neoplastic Drugs

      • Milton B. Yatvin, Theodore C. Cree, Jerry J. Gipp
      Pages 223-234

    5. Liposomes — Further Considerations of Their Possible Role as Carriers of Therapeutic Agents

      • Brenda E. Ryman, Gillian M. Barratt
      Pages 235-248

    6. Therapeutic Efficacy of Cytosine Arabinoside Trapped in Liposomes

      • E. Mayhew, Y. M. Rustum, F. Szoka
      Pages 249-260

    7. Stimulation of Host Response Against Metastatic Tumors by Liposome-Encapsulated Immunomodulators

      • George Poste, Corazon Bucana, Isaiah J. Fidler
      Pages 261-284

    8. Liposomes and the Reticuloendothelial System: Interactions of Liposomes with Macrophages and Behavior of Liposomes In Vivo

      • R. L. Juliano
      Pages 285-300

    9. Immunoadjuvant Properties of Liposomes

      • N. van Rooijen, Ria van Nieuwmegen
      Pages 301-326

    10. Adjuvant Effect of Liposome Presentation of Soluble Tumour Associated Antigen

      • D. Gerlier, J. F. DorĂ©
      Pages 327-336
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Keywords

About this book

Successful drug use in biology and medicine is often prejudiced by the failure of drugs that are otherwise active in vitro to act as efficiently in vivo. This is because in the living animal drugs must, as a rule, bypass or traverse organs, membranes, cells and molecules that stand between the site of administration and the site of action. In practice, however, drugs can be toxic to normal tissues, have limited or no access to the target and be prematurely excreted or inactivated. There is now growing optimism that such problems may be resolved by the use of carrier systems that will not only protect the non-target environment from the drugs they carry but also deliver them to where they are needed or facilitate their release there. Carrier systems presently under investigation include antibodies, glycoproteins, cells, reconstituted viruses and liposomes. Recent advances in the chemistry of cell receptor and receptor-recognising molecules, llnmunology, and natural and artificial membranes have revealed a multitude of ways in which such carrier systems can be modified or improved upon.

Editors and Affiliations

  • Clinical Research Centre, Harrow, UK

    Gregory Gregoriadis, Judith Senior

  • International Institute of Cellular and Molecular Pathology, Brussels, Belgium

    André Trouet

Bibliographic Information

  • Book Title: Targeting of Drugs

  • Editors: Gregory Gregoriadis, Judith Senior, AndrĂ© Trouet

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-4241-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1982

  • Softcover ISBN: 978-1-4684-4243-4Published: 12 December 2012

  • eBook ISBN: 978-1-4684-4241-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 430

  • Topics: Pharmacology/Toxicology

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