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Structural Molecular Biology

Methods and Applications

  • Book
  • © 1982

Overview

Editors:
  1. David B. Davies

    1. University of Birkbeck, London, England

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  2. Wolfram Saenger

    1. Free University of Berlin, West Berlin, Federal Republic of Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. Steven S. Danyluk

    1. Domtar Inc., Senneville, Canada

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Part of the book series: NATO Science Series A: (NSSA, volume 45)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-x
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  3. Methods

    1. X-ray Fiber Diffraction

      • D. A. Marvin, C. Nave
      Pages 3-44

    2. Recent Developments in the Crystallography of Globular Proteins

      • T. L. Blundell
      Pages 45-61

    3. X-ray and Neutron Small Angle Scattering

      • Bernard Jacrot
      Pages 63-85

    4. Image Reconstruction from Electron Micrographs of Macromolecular Structures

      • R. A. Crowther
      Pages 87-112

    5. Magnetic Resonance Probes of Cells

      • Ian C. P. Smith, Roxanne Deslauriers
      Pages 113-159

    6. High Resolution NMR Studies of Nucleic Acids

      • Cornelis Altona
      Pages 161-214

    7. High Resolution NMR Experiments for Studies of Protein Conformations

      • Kurt Wüthrich
      Pages 215-235

    8. Classical and Resonance Raman Spectroscopy of Biological Macromolecules

      • Warner L. Peticolas
      Pages 237-267

    9. Chiroptical Methods and Their Applications to Biomolecular Systems

      • Ignacio Tinoco Jr., Carlos Bustamente, Marcos F. Maestre
      Pages 269-303

    10. Calorimetric Methods for Studying Biomolecular Structure and Organization

      • Theodor Ackermann
      Pages 305-331

    11. Methods for Studying Fast Kinetics in Biological Systems

      • Dietmar Pörschke
      Pages 333-358

    12. Potential Energy Functions for Structural Molecular Biology

      • Shneior Lifson
      Pages 359-385

  4. Applications

    1. The Structure and Dynamics of Water in Globular Proteins

      • J. L. Finney, J. M. Goodfellow, P. L. Poole
      Pages 387-426

    2. Dynamics of Peptides and Proteins

      • Martin Karplus
      Pages 427-453

    3. DNA-Protein Interactions

      • Juan A. Subirana
      Pages 455-473

    4. The Strucure and Assembly of Simple Viruses

      • Kenneth C. Holmes
      Pages 475-505

  5. Back Matter

    Pages 507-530
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Keywords

About this book

Structural biology is undergoing a revolution in both the sophistication of new biophysical methods and the complexity of problems in biomolecular structure and organization opened up for study. These changes are directly attributable to major advances in computer technology, computational methods, development of high­ intensity synchrotron radiation sources, new magnetic resonance methods, laser optical techniques, etc. Structure-function problems previously considered intractable may now be solved. As this area of specialisation continues to expand, there is a need to review the various physical methods currently being used and developed in struc­ tural molecular biology. At the same time that individual techniques and their applications become more specialized, the need for effect­ ive communication between investigators gains in imperative. It is vital to forge links among sub-disciplines and to emphasise the complementary nature of results observed by different biophysical methods. This publication contains the review lectures given at a meeting on "Current Methods in Structural Molecular Biology" spon­ sored by NATO as an Advanced Study Institute and by FEBS ~s Advanced Course No. 78. The aim of the meeting was to bring together, in a teaching environment, students and specialists in diverse biophysical methodologies with the specific purpose of exploring, questioning and critically assessing the present and future state of biological structure research. The scientific content of the interdisciplinary Study Institute centred around three interrelated aspects; biophysical methods and instrumentation, their application to biological structure problems, and derivation of structural information and insights.

Editors and Affiliations

  • University of Birkbeck, London, England

    David B. Davies

  • Free University of Berlin, West Berlin, Federal Republic of Germany

    Wolfram Saenger

  • Domtar Inc., Senneville, Canada

    Steven S. Danyluk

Bibliographic Information

  • Book Title: Structural Molecular Biology

  • Book Subtitle: Methods and Applications

  • Editors: David B. Davies, Wolfram Saenger, Steven S. Danyluk

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-4220-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1982

  • Softcover ISBN: 978-1-4684-4222-9Published: 28 June 2012

  • eBook ISBN: 978-1-4684-4220-5Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: X, 530

  • Number of Illustrations: 151 b/w illustrations

  • Topics: Biological and Medical Physics, Biophysics

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