Nitroimidazoles

1. Front Matter

   Pages i-xii

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2. The Pharmacology and Toxicology of 5-Nitroimidazoles

   • G. L. Biagi

   Pages 1-7

3. Nitroimidazole Chemistry I: Synthetic Methods

   • Bruno Cavalleri

   Pages 9-33

4. Chemical Properties and Reaction Mechanisms of Nitroimidazoles

   • A. Breccia

   Pages 35-48

5. In Vivo Testing of Radiosensitizers

   • Juliana Denekamp

   Pages 49-66

6. Nitroimidazoles as Hypoxia-Mediated Drugs in Cancer Chemotherapy

   • I. J. Stratford, G. E. Adams

   Pages 67-81

7. Metronidazole and Misonidazole in Cancer Chemotherapy: Effect of Cell Density on Drug Activity

   • J. S. Mahood, R. L. Willson

   Pages 83-89

8. Metabolism of Nitroimidazoles

   • D. E. Schwartz, W. Hofheinz

   Pages 91-104

9. Mechanism of Cytotoxicity of Nitroimidazoles

   • D. I. Edwards, R. J. Knox, D. A. Rowley, I. M. Skolimowski, R. C. Knight

   Pages 105-114

10. Nitroimidazoles as Antiparasitic Agents

    • I. de Carneri

    Pages 115-132

11. Resistance to 5-Nitroimidazoles in Pathogenic Microorganisms

    • Miklos Müller

    Pages 133-148

12. Pharmacokinetics of Nitroimidazoles

    • T. R. Marten, R. J. Ruane, J. A. White, L. Clarke

    Pages 149-155

13. The Clinical Pharmacology of Misonidazole in Radiation Therapy Oncology Group Trials

    • Theodore L. Phillips, Todd H. Wasserman

    Pages 157-170

14. Metronidazole and Misonidazole: Absence of Cytogenetic Effects in a Euoxic Bacterial and a Mammalian Cell System In Vitro

    • J. R. Dunlop, J. S. Mahood, R. L. Willson

    Pages 171-179

15. Investigations with Nitroimidazoles in Clinical Oncology

    • Raul C. Urtasun

    Pages 181-188

16. Pharmacokinetic and Therapeutic Studies with Misonidazole and Desmethylmisonidazole in Man

    • Norman M. Bleehen

    Pages 189-201

17. Back Matter

    Pages 203-211

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In July 1979, the Faculty of Pharmacy of the University of Bologna received a proposal from Professor Breccia to hold an International Conference on "Nitroimidazoles: Chemistry, Pharmacology and Clinical Application". Because of the great interest in these drugs in various fields, I was very pleased to accept the proposal and to give to the Conference, the sponsorship of the University of Bologna. It was an added pleasure to accept the chairmanship of the meeting, together with Professors Sensi and Adams. At the same time, the Minister of Education approved the proposal also from the Faculty of Pharmacy, to offer an advanced Course on the tOpic: "Radiosensitizers of Hypoxic Cells". This Course was subsequently approved by a special Committee of the NATO Scientific Programme as an Advanced Study Institute. Since the subject matter of both the Conference and the Course are closely inter-related, it was logical to plan the Conference as part of the overall Course. Bringing together specialists from quite different and apparently unrelated fields of research, but all with an interest in the study and application of one single group of drugs, is a novel idea with intriguing possibilities. The volumes of the proceedings include contributions from experts with such diverse interests as synthetic chemistry, mechanism of drug action, parasitology, anaerobic bacteria and protozoa, pharmacology and toxicology, radiation sensitizers for use in radiotherapy and the development of drugs for use in cancer chemotherapy generally.

• cancer
• chemistry
• chemotherapy
• drug
• pharmacology
• pharmacy
• research
• toxicology

• University of Bologna, Bologna, Italy

  A. Breccia

• Gruppo Lepetit SpA, Milan, Italy

  B. Cavalleri

• Institute of Cancer Research, Sutton, England

  G. E. Adams

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