Molecular Biology, Pathogenicity, and Ecology of Bacterial Plasmids

1. Front Matter

   Pages i-xii

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2. Epidemiology and Ecology of Bacterial Plasmids

   1. Evolution among Antibiotic Resistance Plasmids in the Hospital Environment

      • W. Edmund Farrar Jr.

      Pages 1-10

   2. R Factors Present in Epidemic Strains of Shigella and Salmonella Species Found in Mexico

      • Jorge Olarte

      Pages 11-19

   3. Trimethoprim-Resistant Bacteria in Hospital and in the Community: Spread of Plasmids and Transposons

      • Naomi Datta, Hilary Richards

      Pages 21-30

   4. Ecological Factors That Affect the Survival, Establishment, Growth and Genetic Recombination of Microbes in Natural Habitats

      • G. Stotzky, V. N. Krasovsky

      Pages 31-42

   5. Epidemiology and Genetics of Hemolysin Formation in Escherichia coli

      • Werner Goebel, Angelica Noegel, Ursula Rdest, Dorothee Müller, Colin Hughes

      Pages 43-50

   6. Chromosomal and Plasmid-Mediated Transfer of Clindamycin Resistance in Bacteroides fragilis

      • F. P. Tally, M. J. Shimell, G. R. Carson, M. H. Malamy

      Pages 51-59

   7. Campylobacter jejuni: Characteristic Features of the Organism and Identification of Transmissible Plasmids in Tetracycline-Resistant Clinical Isolates

      • Diane E. Taylor

      Pages 61-70

   8. Studies on Drug Resistance Transposons in Haemophilus influenzae R Plasmids

      • R. Laufs, R. Fock, P.-M. Kaulfers

      Pages 71-80

   9. Plasmids in Streptococci: A Review

      • Donald J. LeBlanc

      Pages 81-90

3. Pathogenicity: Mechanisms and Contributing Factors

   1. Bacterial Pathogenicity, an Overview

      • Stanley Falkow

      Pages 91-100

   2. Cloning and Expression of the Genes Encoding for the Adhesive Antigens K88 and K99

      • J. D. A. van Embden, F. K. de Graaf, F. R. Mooi, W. Gaastra, I. G. W. Bijlsma

      Pages 101-109

   3. Invasive Bacterial Pathogens of the Intestine: Shigella Virulence Plasmids and Potential Vaccine Approaches

      • Dennis J. Kopecko, Philippe J. Sansonetti, Louis S. Baron, Samuel B. Formal

      Pages 111-121

   4. Plasmid-Specified Iron Uptake by Bacteraemic Strains of Escherichia coli

      • Peter H. Williams, Philip J. Warner

      Pages 123-132

   5. Serum Resistance in E.coli

      • Kenneth N. Timmis, Paul A. Manning, Christine Echarti, Joan K. Timmis, Albrecht Moll

      Pages 133-144

4. Mechanisms of Resistance

   1. Antibiotic Resistance — A Survey

      • Julian E. Davies

      Pages 145-156

   2. Regulation of Plasmid Specified MLS-Resistance in Bacillus subtilis by Conformational Alteration of RNA Structure

      • D. Dubnau, G. Grandi, R. Grandi, T. J. Gryczan, J. Hahn, Y. Kozloff et al.

      Pages 157-167

   3. Control and DNA Structure of the ampC β-Lactamase Gene of Escherichia coli

      • Bengtåke Jaurin, Thomas Grundström, Sven Bergström, Staffan Normark

      Pages 169-178

   4. Mechanisms of Plasmid-Determined Heavy Metal Resistances

      • Simon Silver

      Pages 179-189

5. Transfer and Mobilization of Plasmids

   1. Conjugation and Resistance Transfer in Streptococci and Other Gram Positive Species: Plasmids, Sex Pheromones and “Conjugative Transposons” (A Review)

      • Don B. Clewell

      Pages 191-205

This book resulted from presentations at an international conference on bacterial p1asmids held January 5-9, 1981 in Santo Domingo, Dominican Republic. This was the first meeting of its kind in the Southern Hemisphere. The meeting place was selected for its relaxed and comfortable climate, conducive to interactions among participants. More importantly the locale facilitated the participation of nearby Latin American clinical and research scientists who deal directly with the health manifestations of pathogenic p1asmids. Diseases and socio-economic practices of developing countries exist in the Dominican Republic whose scientific community could directly benefit from having the meeting there. The book includes the talks as well as extended abstracts of poster presentations from the meeting. This combination, which provides readers with reviews as well as recent findings, captures the full scientific exchange which took place during the 5-day meeting. As one indication of pathogenicity related to p1asmids, the conferees were surveyed for gastro-intestina1 problems during and after their stay in the Dominican Republic. The results are summarized at the end of this book.

• biology
• climate
• ecology
• molecular biology

• Tufts University School of Medicine, Boston, USA

  Stuart B. Levy

• The University of Texas at Dallas, Richardson, USA

  Royston C. Clowes

• Universidad Nacional Pedro Henriquez Urena, Santo Domingo, Dominican Republic

  Ellen L. Koenig

Policies and ethics