In Situ Expression of Tumor Immunity

1. Front Matter

   Pages i-xviii

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2. A Review of Data, Problems, and Open Questions Pertaining to in Situ Tumor Immunity

   • Stephen W. Russell, Isaac P. Witz, Ronald B. Herberman

   Pages 1-20

3. Separation of Individual Kinds of Cells from Tumors

   • Thomas G. Pretlow II, Theresa P. Pretlow

   Pages 21-59

4. Immunologic Reactivity of Lymphoid Cells in Tumors

   • Ronald B. Herberman, Howard T. Holden, Luigi Varesio, Tadayoshi Taniyama, Paolo Puccetti, Holger Kirchner et al.

   Pages 61-78

5. Separation and Characteristics of Tumor-Infiltrating Lymphocytes in Man

   • E. Klein, F. Vánky, U. Galili, B. M. Vose, M. Fopp

   Pages 79-107

6. Intratumor Host Cells of Experimental Rat Neoplasms: Characterization and Effector Function

   • M. Moore, K. Moore

   Pages 109-142

7. Evidence for Mononuclear Phagocytes in Solid Neoplasms and Appraisal of Their Nonspecific Cytotoxic Capabilities

   • Stephen W. Russell, G. Yancey Gillespie, Judith L. Pace

   Pages 143-166

8. Mononuclear Cells IgG Associated with Human Malignant Tissue

   • O. Tønder, R. Matre, F. Wesenberg

   Pages 167-176

9. Evidence for Membrane-Bound Antibodies Directed against Antigens Expressed on Tumors

   • S. von Kleist, M. King, C. Huet

   Pages 177-189

10. Tumor-Localizing Lymphocytotoxic Antibodies

    • Maya Ran, Margalit Yaakubowicz, Ora Amitai, Isaac P. Witz

    Pages 191-211

11. Correlations between Tumor Antigenicity, Malignant Potential, and Local Host Immune Response

    • Harry L. Ioachim

    Pages 213-238

12. Host Cell Analysis of a Rapidly Metastasizing Mouse Tumor and Derived Low-Metastatic Variant Lines

    • R. S. Kerbel, R. R. Twiddy, P. Frost

    Pages 239-253

13. Cellular Basis for Regulation of Tumor Growth

    • Robert Evans

    Pages 255-266

14. Immunological Stimulation in Situ: The Acute and Chronic Inflammatory Responses in the Induction of Tumor Immunity

    • M. G. Hanna Jr., C. D. Bucana, V. A. Pollack

    Pages 267-296

15. Tumor Immunity in the Peritoneal Cavity

    • Gideon Berke, Barbara Schick

    Pages 297-315

16. The Multicellular Tumor Spheroid: A Quantitative Model for Studies of in Situ Immunity

    • H. Robson MacDonald, Bernard Sordat

    Pages 317-342

17. Back Matter

    Pages 343-348

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Because of several valid (and some invalid) reasons, the research field of tumor immunology has been declining in popularity. The Simplistic dogmas, articles of faith, and theories of the late 1960s and early 1970s on the immuno­ logical mechanisms of the host-tumor interrelationships have frequently been refuted by some of the new developments in cancer biology, cancer biochem­ istry, and immunology. Furthermore, some of the conventional assays used to monitor "tumor-host immune relations" did not always reflect the host's true clinical situation or his prognosis. Several approaches to immunological interven­ tion were less successful than expected. In addition, the concept of "immune surveillance," which was basic to many researchers in the field of cancer im­ munology, seemed to fall apart. Much of the criticism was based on results from solid, well-performed, and well-controlled experiments, but there was also un­ just criticism based on ill-conceived and badly performed studies, and on misin­ terpretations of experimental data. There are many misconceptions about the tumor-host relationship. It is very often assumed that tumor immunity, as expressed systemically, is truly reflected at the tumor site. Several studies reported in this volume and elsewhere indicate that such is not always the case. Certain immune effectors may be selectively prevented from reaching the tumor site or the close vicinity of the tumor cells because of mechanical or chemical barriers, whereas others may be selectively attracted to the site by chemotaxis or other mechanisms.

• Antigen
• biology
• cancer
• cell
• immunobiology
• lymphocytes
• tissue
• tumor
• tumor growth

• Department of Microbiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

  Isaac P. Witz

• Cancer Biology Program, NCI Frederick Cancer Research Center, Frederick, USA

  M. G. Hanna

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