Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures

1. Front Matter

   Pages i-xiii

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2. Short-Term Bioassay Systems-An Overview

   1. Front Matter

      Pages 1-1

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   2. The use of Microbial Assay Systems in the Detection of Environmental Mutagens in Complex Mixtures

      • Herbert S. Rosenkranz, Elena C. McCoy, Monica Anders, William T. Speck, David Bickers

      Pages 3-42

   3. Mutagenesis of Mammalian Cells by Chemical Carcinogens after Metabolic Activation

      • Eliezer Huberman, Robert Langenbach

      Pages 43-62

   4. Oncogenic Transformation of Mammalian Cells by Chemicals and Viral-Chemical Interactions

      • Bruce C. Casto

      Pages 63-97

   5. Higher Plant Systems as Monitors of Environmental Mutagens

      • Frederick J. de Serres

      Pages 99-109

   6. The Role of Drosophila in Chemical Mutagenesis Testing

      • Carroll E. Nix, Bobbie Brewen

      Pages 111-123

   7. The Cellular Toxicity of Complex Environmental Mixtures

      • Michael D. Waters, Joellen L. Huisingh, Neil E. Garrett

      Pages 125-167

3. Collection and Chemical Analysis of Environmental Samples

   1. Front Matter

      Pages 169-169

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   2. Atmospheric Genotoxicants—What Numbers Do We Collect?

      • Eugene Sawicki

      Pages 171-194

   3. State-Of-The-Art Analytical Techniques for Ambient Vapor Phase Organics and Volatile Organics in Aqueous Samples from Energy-Related Activities

      • Edo D. Pellizzari

      Pages 195-225

   4. Strategy for Collection of Drinking Water Concentrates

      • Carl C. Smith

      Pages 227-244

4. Current Research

   1. Front Matter

      Pages 245-245

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   2. Short-Term Bioassay of Complex Organic Mixtures: Part I, Chemistry

      • M. R. Guerin, B. R. Clark, C.-h. Ho, J. L. Epler, T. K. Rao

      Pages 247-268

   3. Short-Term Bioassay of Complex Organic Mixtures: Part II, Mutagenicity Testing

      • J. L. Epler, B. R. Clark, C.-h. Ho, M. R. Guerin, T. K. Rao

      Pages 269-289

   4. Quantitative Mammalian Cell Genetic Toxicology: Study of the Cytotoxicity and Mutagenicity of Seventy Individual Environmental Agents Related to Energy Technologies and Three Subfractions of a Crude Synthetic Oil in the CHO/HGPRT System

      • Abraham W. Hsie, J. Patrick O’Neill, Juan R. San Sebastian, David B. Couch, Patricia A. Brimer, William N. C. Sun et al.

      Pages 291-315

   5. Environmental Testing

      • C. W. Gehrs, B. R. Parkhurst, D. S. Shriner

      Pages 317-330

   6. Integrating Microbiological and Chemical Testing Into the Screening of Air Samples for Potential Mutagenicity

      • Edo D. Pellizzari, Linda W. Little, Charles Sparacino, Thomas J. Hughes, Larry Claxton, Michael D. Waters

      Pages 331-351

   7. Chemical and Microbiological Studies of Mutagenic Pollutants in Real and Simulated Atmospheres

      • James N. Pitts Jr., Karel A. Van Cauwenberghe, Daniel Grosjean, Joachim P. Schmid, Dennis R. Fitz, William L. Belser Jr. et al.

      Pages 353-379

   8. Application of Bioassay to the Characterization of Diesel Particle Emissions

      • J. Huisingh, R. Bradow, R. Jungers, L. Claxton, R. Zweidinger, S. Tejada et al.

      Pages 381-418

vi Williamsburg, Virginia, February 21-23, 1978. This symposium was sponsored by the U. S. Environmental Protection Agency, Office of Energy Minerals and Industry, Washington, DC, and Office of Health and Ecological Effects, Health Effects Re­ search Laboratory, Biochemistry Branch, Research Triangle Park, NC. The symposium consisted of 24 formal presentations that amplify the three major topics discussed during the symposium: an overview of short-term bioassay systems; current methodology involving the collection and chemical analysis of environmental samples; and current research in­ volving the use of short-term bioassays in the fractionation and analysis of complex environmental mixtures. The purpose of this symposium was to present the state-of-the-art tech­ niques in bioassay and chemical analysis as applied to com­ plex mixtures and to foster continued advancement of this important area. Complex mixtures discussed include ambient air and water, waste water, drinking water, shale oil, syn­ thetic fuels, automobile exhaust, diesel particulate, coal fly ash, cigarette smoke condensates, and food products. It is our hope that this volume will serve as a refer­ ence to catalyze and encourage further research in this field. Michael D. Waters, Ph. D. Stephen Nesnow, Ph. D. vii Acknowledgment We would like to thank Gerald Rausa, Office of Energy Minerals and Industry, for his advice, encouragement, and support of this program. We would also like to express our appreciation to Wendy A. Martin, Peter A. Murphy, and David F. Wright of Kappa Systems, Inc.

• Potential
• atmosphere
• chemistry
• energy
• environment
• environmental protection
• health
• toxicology

• U.S. Environmental Protection Agency, Research Triangle Park, USA

  Michael D. Waters, Stephen Nesnow, Joellen L. Huisingh, Shahbeg S. Sandhu, Larry Claxton

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