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Modulators, Mediators, and Specifiers in Brain Function

Interactions of Neuropeptides, Cyclic Nucleotides, and Phosphoproteins in Mechanisms Underlying Neuronal Activity, Behavior, and Neuropsychiatric Disorders

  • Book
  • © 1979

Overview

Editors:
  1. Yigal H. Ehrlich

    1. The Missouri Institute of Psychiatry, University of Missouri - Columbia School of Medicine, St. Louis, USA

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  2. Jan Volavka

    1. The Missouri Institute of Psychiatry, University of Missouri - Columbia School of Medicine, St. Louis, USA

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  3. Leonard G. Davis

    1. The Missouri Institute of Psychiatry, University of Missouri - Columbia School of Medicine, St. Louis, USA

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  4. Eric G. Brunngraber

    1. The Missouri Institute of Psychiatry, University of Missouri - Columbia School of Medicine, St. Louis, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 116)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xv
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  2. Mechanisms of Neuronal Communication

    1. Front Matter

      Pages 1-1
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    2. Three Modes of Communication in the Nervous System

      • Jeffery L. Barker, Thomas G. Smith Jr.
      Pages 3-25

    3. Do Behaviorally Active Polypeptide Hormones Act at Crucial “Command” Sites or at Many Sites, from “Command” Down to “Final Common Paths”?

      • Jeffrey L. Ram
      Pages 27-39

    4. Neurotransmitters and Neuromodulators and their Mediation by Cyclic Nucleotides

      • G. R. Siggins
      Pages 41-64

    5. Metabolic Factors Affecting Brain Cyclic Nucleotides

      • L. Volicer, R. Mirin, R. Meichner
      Pages 65-74

    6. Phosphoproteins as Specifiers for Mediators and Modulators in Neuronal Function

      • Yigal H. Ehrlich
      Pages 75-101

    7. Phosphoproteins as Proposed Modulators of Visual Function

      • D. B. Farber, R. N. Lolley
      Pages 103-115

    8. Evidence for the Presence of Substrates for cGMP Dependent Protein Phosphorylation in Human Synaptosomal Membranes

      • D. H. Boehme, R. Kosecki, N. Marks
      Pages 117-129

  3. Interaction of Neuropeptides, Cyclic Nucleotides and Phosphoproteins in Mechanisms Underlying Receptor Function

    1. Front Matter

      Pages 131-131
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    2. Regulation of Central Adrenergic Receptors

      • David B. Bylund
      Pages 133-162

    3. Regulation of the Neuroblastoma X Glioma Hybrid Opiate Receptors by Na+ and Guanine Nucleotides

      • Arthur J. Blume, Gloria Boone, David Lichtshtein
      Pages 163-174

    4. Phosphorylation of the Acetylcholine Receptor

      • A. S. Gordon, I. Diamond
      Pages 175-198

    5. The Behaviorally Active Neuropeptide ACTH as Neurohormone and Neuromodulator: The Role of Cyclic Nucleotides and Membrane Phosphoproteins

      • W. H. Gispen, H. Zwiers, V. M. Wiegant, P. Schotman, J. E. Wilson
      Pages 199-224

    6. Opioid Peptides as Modulators of Cyclic AMP Levels

      • Werner A. Klee
      Pages 225-231

    7. Opioid Peptides and Protein Phosphorylation

      • Leonard G. Davis, Yigal H. Ehrlich
      Pages 233-244
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Keywords

About this book

While neuroanatomy and neurophysiology were defining the unique features of the synapse as a site for cell to cell signaling in the late fifties, neurochemistry was establishing the identity and studying the biosynthetic pathways of monoamine neurotransmitters. Meanwhile, neuropsychiatry was keeping a vigilant eye on the outcome of this concerted effort with the untold hope that a genetic defect in neurotransmitter metabolism would ac­ count for the pathogenesis of certain psychiatric ill­ nesses. Thus, when neurochemists in the early sixties began to study the feasibility of measuring the metabolism of brain neurotransmitters in vivo, clinical biochemists eagerly adopted these methods to their needs and sought to verify whether inborn errors of transmitter biogenesis were a cause for at least certain forms of depression, mania and schizophrenia. Undoubtedly, it is still too early to evaluate the outcome of these studies. However, current opinion holds that gross inborn errors in transmitter metabolism do not anpear to be operative as a primary cause of psychia­ tric disorders. Though monoamine metabolism appears to be defective in certain groups of psychiatric disorders, the cause of these changes can at best be associated with changes in patterns of neuronal firing. It is generally believed that these persistent changes are determined by a number of unknown factors operative in various psychia­ tric illnesses. In the attempt to identify the molecular nature of these unknown factors, the focus of current research is directed toward transmitter receptors.

Editors and Affiliations

  • The Missouri Institute of Psychiatry, University of Missouri - Columbia School of Medicine, St. Louis, USA

    Yigal H. Ehrlich, Jan Volavka, Leonard G. Davis, Eric G. Brunngraber

Bibliographic Information

  • Book Title: Modulators, Mediators, and Specifiers in Brain Function

  • Book Subtitle: Interactions of Neuropeptides, Cyclic Nucleotides, and Phosphoproteins in Mechanisms Underlying Neuronal Activity, Behavior, and Neuropsychiatric Disorders

  • Editors: Yigal H. Ehrlich, Jan Volavka, Leonard G. Davis, Eric G. Brunngraber

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-3503-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1979

  • Softcover ISBN: 978-1-4684-3505-4Published: 31 August 2012

  • eBook ISBN: 978-1-4684-3503-0Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XV, 327

  • Topics: Neurosciences

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