Biological Regulation and Development

1. Front Matter

   Pages i-xvii

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2. Strategies of Genetic Regulation in Prokaryotes

   • Robert F. Goldberger

   Pages 1-18

3. Structure of Complex Operons

   • Allan Campbell

   Pages 19-55

4. Autogenous and Classical Regulation of Gene Expression: A General Theory and Experimental Evidence

   • Michael A. Savageau

   Pages 57-108

5. Regulation of Enzyme Synthesis in the Bacteria: A Comparative and Evolutionary Study

   • Patricia H. Clarke

   Pages 109-170

6. Importance of Symmetry and Conformational Flexibility in DNA Structure for Understanding Protein-DNA Interactions

   • Henry M. Sobell

   Pages 171-199

7. Some Aspects of the Regulation of DNA Replication in Escherichia coli

   • Karl G. Lark

   Pages 201-217

8. Genetic Control Signals in DNA

   • David Pribnow

   Pages 219-277

9. On the Molecular Bases of the Specificity of Interaction of Transcriptional Proteins with Genome DNA

   • Peter H. von Hippel

   Pages 279-347

10. Genetic Signals and Nucleotide Sequences in Messenger RNA

    • Joan Argetsinger Steitz

    Pages 349-399

11. The Role of tRNA in Regulation

    • Riccardo Cortese

    Pages 401-432

12. Suppression

    • Deborah A. Steege, Dieter G. Söll

    Pages 433-485

13. Regulation of the Protein-Synthesizing Machinery—Ribosomes, tRNA, Factors, and So On

    • O. Maaløe

    Pages 487-542

14. Back Matter

    Pages 543-558

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The motivation for us to produce a treatise on regulation was mainly our convic­ tion that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We had ourselves written reviews for various volumes over the years, most of them bringing together all possible facts relevant to a particular operon, virus, or biosynthetic system. And we were not convinced of the value of such reviews for anyone but the expert in the field reviewed. We thought it might be more interesting and more instructive-for both author and reader-to avoid reviewing topics that anyone scientist might work on, but instead to review the various parts of what many different scientists work on. Cutting across the traditional boundaries that have separated the subjects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who possess sufficient breadth of knowledge and who are willing to write about areas outside those pursued in their own laboratories. For example, no one scientist works on suppression per se. He may study the structure of suppressor tRNAs in Escherichia coli, he may study phenotypic suppression of various characters in drosophila, he may study polarity in gene expression, and so on.

• DNA
• Glutamin
• Nucleotide
• RNA
• amino acid
• biology
• enzyme
• enzymes
• gene expression
• metabolism
• mutation
• nucleic acid
• tRNA
• transcription
• translation

• Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, USA

  Robert F. Goldberger

Policies and ethics