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Calcium in Drug Action

  • Book
  • © 1978

Overview

Editors:
  1. George B. Weiss

    1. University of Texas Health Science Center, Southwestern Medical School, Dallas, USA

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-ix
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  2. Analysis and Alteration of Calcium Ion Distribution and Movements

    1. Front Matter

      Pages 1-2
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    2. Calcium, Calcium Translocation, and Specific Calcium Antagonists

      • L. Rosenberger, D. J. Triggle
      Pages 3-31

    3. Surface Calcium in the Heart: Its Function and Role in Drug Action

      • Joy S. Frank
      Pages 33-56

    4. Quantitative Measurement of Binding Sites and Washout Components for Calcium Ion in Vascular Smooth Muscle

      • George B. Weiss
      Pages 57-74

    5. Calcium in Smooth Muscle Function

      • Leon Hurwitz, Linda J. McGuffee
      Pages 75-93

  3. Subcellular Sites and Interactions: Calcium and Drugs

    1. Front Matter

      Pages 95-96
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    2. Effects of Calcium on Adenylate Cyclase, as Part of the Ca2+-cAMP Feedback in Biological Communication

      • Gideon A. Rodan
      Pages 97-133

    3. Prostaglandins, Calcium, and Cyclic Nucleotides in Stimulus-Response Coupling

      • Ronald P. Rubin, Suzanne G. Laychock
      Pages 135-155

    4. Regulation of Calcium by Vascular Smooth Muscle Cellular Components

      • Julius C. Allen
      Pages 157-171

    5. Role of Calcium in the Actions of Agents Affecting Membrane Permeability

      • James W. Putney Jr.
      Pages 173-194

  4. Calcium in Drug Action: Some Specific Biological Systems

    1. Front Matter

      Pages 195-196
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    2. The Role of Calcium in Blood Platelet Function

      • Maurice B. Feinstein
      Pages 197-239

    3. Effects of Opiate Drugs on the Metabolism of Calcium in Synaptic Tissue

      • David H. Ross
      Pages 241-259

    4. Calcium and Neuromuscular Transmission

      • William Van der Kloot
      Pages 261-287

    5. Role of Calcium in Desensitization at the Motor End-Plate of Skeletal Muscle

      • Rodney L. Parsons
      Pages 289-313

    6. Effect of Pharmacological Agents on Calcium Stores in Amphibian Fast and Slow Muscle Fibers

      • C. Paul Bianchi
      Pages 315-330

    7. Calcium Related Basis of Action of Vascular Agents: Cellular Approaches

      • Frank R. Goodman
      Pages 331-354

  5. Back Matter

    Pages 355-366
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Keywords

About this book

Anyone surveying physiological and pharmacological journals can readily see that the biological actions of calcium ion are of increasingly widespread current interest. The scope of investi­ gated actions and reactions in which a role for calcium ion is of some importance is so numerous as to convey the impression that calcium ion is everywhere and interacts with everything. This being so, the challenge in contemporary research is to focus on investigation of those actions of calcium ion which, in some manner, influence either significant physiological parameters or the manner in which pharmacological agents act. This multi-authored book originated from a more limited Symposium on "Importance of Calcium as a Primary Locus of Drug Action" co-chaired by myself and Dr. Frank R. Goodman at the April, 1977 FASEB meeting in Chicago. This Symposium was organized in response to a perceived need for increased communication among 2 workers in different areas of Ca +-related research. In the pro­ cess of selecting the maximum of six areas for presentation within the format provided, it soon became apparent that this would result in only a limited sampling of current research efforts. Expansion of the number of areas to fourteen within a book format appeared to be the most logical mechanism to provide a more coherent inter­ disciplinary approach to consideration of various aspects of the 2 roles of Ca + in drug action. This is not to imply that all rele­ 2 vant Ca +-related areas are surveyed within this volume.

Editors and Affiliations

  • University of Texas Health Science Center, Southwestern Medical School, Dallas, USA

    George B. Weiss

Bibliographic Information

  • Book Title: Calcium in Drug Action

  • Editors: George B. Weiss

  • DOI: https://doi.org/10.1007/978-1-4684-3354-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1978

  • Softcover ISBN: 978-1-4684-3356-2Published: 22 March 2012

  • eBook ISBN: 978-1-4684-3354-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 366

  • Topics: Pharmacology/Toxicology

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