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Purine Metabolism in Man

Enzymes and Metabolic Pathways

  • Book
  • © 1974

Overview

Editors:
  1. Oded Sperling

    1. Division of Metabolic Disease, Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Petah-Tikva, Israel

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  2. Andre Vries

    1. Division of Metabolic Disease, Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Petah-Tikva, Israel

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    You can also search for this editor in PubMed   Google Scholar

  3. James B. Wyngaarden

    1. Department of Medicine, Duke University Medical Center, Durham, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 41A)

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Table of contents (43 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Enzymes and Metabolic Pathways in Purine Metabolism

    1. Front Matter

      Pages 1-1
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    2. Purine Phosphoribosyltransferases

      1. Human Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT): Purification and Properties
        • W. J. Arnold, R. V. Lamb III, W. N. Kelley
        Pages 5-14
      2. Stabilization by PRPP of Cellular Purine Phosphoribosyltransferases Against Inactivation by Freezing and Thawing. Study of Normal and Hypoxanthine-Guanine Phosphoribosyltransferase Deficient Human Fibroblasts
        • E. Zoref, O. Sperling, A. de Vries
        Pages 15-18
      3. Purification and Characterization of a Neural Hypo-Xanthine-Guanine-Phosphoribosyltransferase (HGPRT)
        • Wolf Gutensohn
        Pages 19-22
      4. Human Adenine Phosphoribosyltransferase: Purification, Subunit Structure and Substrate Specificity
        • C. B. Thomas, W. J. Arnold, W. N. Kelley
        Pages 23-32
      5. Genetic Control of Bacterial Purine Phosphoribosyltransferases and an Approach to Gene Enrichment
        • Joseph S. Gots, Charles E. Benson
        Pages 33-39

    3. Glutamine-PRPP Amidotransferase

      1. Human Glutamine Phosphoribosylpyrophosphate (PP-ribose-P) Amidotransferase: Kinetic, Regulation and Configurational Changes
        • E. W. Holmes Jr., J. B. Wyngaarden, W. N. Kelley
        Pages 43-53

    4. Xanthine Oxidase

      1. Xanthine Oxidase and Aldehyde Oxidase in Purine and Purine Analogue Metabolism
        • Thomas A. Krenitsky
        Pages 57-64
      2. Regulation of Xanthine Dehydrogenase and Purine Nucleoside Phosphorylase Levels in Chick Liver
        • J. R. Fisher, W. D. Woodward, P. C. Lee, J. Wu
        Pages 65-74
      3. Xanthine Oxidase Activity of Mammalian Cells
        • H. Brunschede, R. S. Krooth
        Pages 75-76

    6. Nucleoside and Nucleotide Metabolism

      1. Purine Salvage in Spleen Cells
        • G. Partsch, H. Altmann, R. Eberl
        Pages 103-111
      2. Purine Nucleotide Synthesis, Interconversion and Catabolism in Human Leukocytes
        • J. F. Henderson, E. E. McCoy, J. H. Fraser
        Pages 113-116
      3. Incorporation of Purine Analogs into the Nucleotide Pools of Human Erythrocytes
        • R. E. Parks Jr., Phyllis R. Brown, Chong M. Kong
        Pages 117-127
      4. A Role of Liver Adenosine in the Renewal of the Adenine Nucleotides of Human and Rabbit Erythrocytes
        • Bertram A. Lowy, Marvin H. Lerner
        Pages 129-139
      5. Purine Nucleoside Metabolism in Escherichia Coli
        • Bjarne Jochimsen
        Pages 141-146
      6. Synthesis of Purine Nucleotides in Human and Leukemic Cells. Interaction of 6-Mercaptopurine and Allopurinol
        • W. Wilmanns
        Pages 147-158
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Keywords

About this book

Gout and uric acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of uric acid excretion, although still posing difficult problems, appears to approach clari­ fication.

Editors and Affiliations

  • Division of Metabolic Disease, Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Petah-Tikva, Israel

    Oded Sperling, Andre Vries

  • Department of Medicine, Duke University Medical Center, Durham, USA

    James B. Wyngaarden

Bibliographic Information

  • Book Title: Purine Metabolism in Man

  • Book Subtitle: Enzymes and Metabolic Pathways

  • Editors: Oded Sperling, Andre Vries, James B. Wyngaarden

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-3294-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1974

  • Softcover ISBN: 978-1-4684-3296-1Published: 25 February 2013

  • eBook ISBN: 978-1-4684-3294-7Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXIII, 366

  • Topics: Biochemistry, general

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