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Hemoglobin and Red Cell Structure and Function

Proceedings of the Second International Conference on Red Cell Metabolism and Function held at the University of Michigan Ann Arbor, April 27–29, 1972

  • Conference proceedings
  • © 1972

Overview

Editors:
  1. George J. Brewer

    1. Department of Human Genetics and Medicine (Simpson Memorial Institute), University of Michigan, Ann Arbor, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 28)

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Table of contents (38 papers)

  1. Front Matter

    Pages i-xxxii
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  2. Hemoglobin Structure and Function

    1. Front Matter

      Pages 1-1
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    2. Structure of Haemoglobin M Milwaukee, A Mutant Form Exhibiting Interaction Between Ferrous and Ferric Subunits

      • M. F. Perutz, P. D. Pulsinelli, Helen M. Ranney
      Pages 3-18

    3. The Interaction Between Hemoglobin and Its “Oxygen-Linked” Ligands

      • O. Brenna, M. Luzzana, M. Pace, M. Perrella, F. Rossi, L. Rossi-Bernardi et al.
      Pages 19-40

    4. The Interaction of Sickle Hemoglobin with DPG, CO2 and with Other Hemoglobins: Formation of Asymmetrical Hybrids

      • H. Franklin Bunn
      Pages 41-53

    5. Enhancement of the Acid and Alkaline Bohr Effects of Hemoglobin by Organic Phosphates

      • Austen Riggs, Takashi Imamura
      Pages 55-63

    6. Functional Non-Equivalence of α and β Hemes in Human Hemoglobins

      • Chien Ho, Ted R. Lindstrom
      Pages 65-76

  3. Red Cell Metabolism and Function

    1. Front Matter

      Pages 77-77
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    2. Hemoglobin Casper G8 β106 Leu→ Pro: Further Evidence that Hemoglobin Mutations are Not Random

      • R. T. Jones, R. D. Koler, M. Duerst, Z. Stocklen
      Pages 79-98

    3. Potential Effects of Hemoglobin Concentration on Red Cell Metabolism Together with Observations on Red Cell Metabolic Differences Between Men and Women

      • George J. Brewer, Fred J. Oelshlegel Jr., Eric B. Schoomaker, Conrad A. Knutsen
      Pages 99-119

    4. Catalase Activity and Red Cell Metabolism

      • John W. Eaton, Martin Boraas, Nina L. Etkin
      Pages 121-131

    5. Red Cell Hexosemonophosphate Shunt Deficiency in Uremia

      • Harry Jacob, Yoshihito Yawata, Robert Howe
      Pages 133-143

    6. Effect of Inorganic Phosphate on Red Cell Metabolism: In Vitro and In Vivo Studies

      • Michael C. Brain, Robert T. Card
      Pages 145-154

    7. Studies of the Metabolic Basis of the ATP-DPG Differences in Genetically Selected High and Low ATP-DPG Rat Strains

      • Nancy A. Noble, George J. Brewer
      Pages 155-164

  4. Carbonic Anhydrase and Carbon Dioxide Transport

    1. Front Matter

      Pages 165-165
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    2. Introductory Remarks at the Beginning of Session III

      • Richard E. Tashian
      Pages 167-168

    3. Functional Aspects of the Three-Dimensional Structure of the Active Site of Carbonic Anhydrase

      • Ivar Waara, Seved Lövgren, Anders Liljas, K. K. Kannan, Per-Christer Bergstén
      Pages 169-187

    4. The Effect of Temperature on the Catalytic Activity of Bovine Carbonic Anhydrase

      • John C. Kernohan
      Pages 189-199

    5. Carbonic Anhydrase, Red Cell Membranes, and CO2 Transport

      • Theodore Enns
      Pages 201-208

    6. Effect of Chlorthalidone Binding on the Electrophoretic Properties of Human Red Cell Carbonic Anhydrase Isozymes

      • Richard E. Tashian, Ya-Shiou L. Yu
      Pages 209-213
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Keywords

About this book

Hemoglobin and the red cell have continued to set a dizzying pace as the objects of research in the two and one-half year interval since the First International Conference on Red Cell Metabolism and Function. Most exciting perhaps, is a beginning molecular attack on sickle cell disease. The story of the inter­ action of red cell metabolism and oxygen transport has continued to unfold, and we can now infer that patients with hypoxia usually utilize red cell metabolic adjustments to improve oxygenation. This puts the red cell squarely in the center of medical practice, since much of medicine-heart, pulmonary, and blood disease- deals with inadequate oxygenation. On April 27th through the 29th, 1972, crystallographers, chemists, biochemists, physiologists, geneticists, and physi­ cians from many medical disciplines met in the Towsley Center for Continuing Medical Education at the University of Michigan, Ann Arbor to present new data, to review recent developments, and to try to piece together additional features of the red cell puzzle. The meeting was dedicated to Dr. Francis John Worsley Roughton, Professor Emeritus of Colloid Science, University of Cambridge, England, in recognition of his numerous excellent contributions to the understanding of hemoglobin and red cell function. The program got off to a good start with a paper from M. F. Perutz, Nobel Laureate, on the structure of hemoglobin. Dr.

Editors and Affiliations

  • Department of Human Genetics and Medicine (Simpson Memorial Institute), University of Michigan, Ann Arbor, USA

    George J. Brewer

Bibliographic Information

  • Book Title: Hemoglobin and Red Cell Structure and Function

  • Book Subtitle: Proceedings of the Second International Conference on Red Cell Metabolism and Function held at the University of Michigan Ann Arbor, April 27–29, 1972

  • Editors: George J. Brewer

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-3222-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1972

  • Softcover ISBN: 978-1-4684-3224-4Published: 13 April 2012

  • eBook ISBN: 978-1-4684-3222-0Published: 08 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXXII, 526

  • Topics: Hematology

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