Shock: Biochemical, Pharmacological, and Clinical Aspects

1. Front Matter

   Pages i-xiii

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2. Pathogenesis of Shock

   1. Front Matter

      Pages 1-1

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   2. Effects of Hemorrhagic and Catecholamine Shock on Canine Forelimb Transcapillary Fluid Fluxes and Segmental Vascular Resistances

      • George J. Grega, James M. Schwinghamer, Francis J. Haddy

      Pages 3-14

   3. Renal Failure in Hemorrhagic Shock

      • Kurt Kramer

      Pages 15-25

   4. A Consideration of the Role of the Reticuloendothelial System (RES) in Endotoxin Shock

      • N. R. Di Luzio, Clifford G. Crafton

      Pages 27-57

   5. Behaviour of Histidine Decarboxylase (HDC) in Various Forms of Shock

      • A. Schauer, L. Gielow, G. Geissl

      Pages 59-72

   6. Extrinsic Versus Intrinsic, Coagulation-Fibrinolysis: In the Pathophysiology of Shock and Exsanguinating Diatheses

      • Charles L. Schneider

      Pages 73-92

   7. Complement and Shock

      • Desiree Armstrong

      Pages 93-101

   8. The Role of Splancnic Adrenergic Vasoconstriction in the Development of Irreversibility of Hemorrhagic Shock

      • Gian Paolo Novelli, Camillo Cortesini, Elio Pagni

      Pages 103-116

   9. Circulatory Function in the Early Postoperative Period After Pulmonary Surgery

      • Bengt Wranne

      Pages 117-124

   10. Proposed Mechanisms for the Ameliorative Effects of Corticosteroids in Shock

       • J. C. Houck, J. A. Gladner

       Pages 125-132

3. Biochemical Pathology of Shock

   1. Front Matter

      Pages 133-133

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   2. Participation of the Kinin-System in Different Kinds of Shock

      • M. Rocha e Silva

      Pages 135-151

   3. The Generation of Kinins in the Circulation of the Dog During Hypotension Due to Blood Loss

      • H. Berry, J. G. Collier, J. R. Vane

      Pages 153-157

   4. Pathophysiologic Mechanisms in Endotoxin Shock and its Therapeutic Approaches

      • H. Neuhof, E. Glaser, D. Hey, H. G. Lasch

      Pages 159-170

   5. Several Pharmacologic and Biochemical Aspects of Cysteamine- and Cystamine-Induced Shock

      • P. van Caneghem, J. Lecomte, Z. M. Bacq, M. L. Beaumariage

      Pages 171-187

   6. Effect of Varying Blood Sugar Level in Anaphylactic Shock

      • H. L. Dhar

      Pages 189-197

4. Pharmacology of Shock

   1. Front Matter

      Pages 199-199

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   2. The Influence of Blood pH on Peripheral Vascular Tone: Possible Role of Proteases and Vaso-Active Polypeptides

      • H. Wilkens, N. Back, R. Steger, J. Karn

      Pages 201-214

   3. The Influence of Some Enzymes and Enzyme Inhibitors in Shock

      • A. Bertelli, L. Donati

      Pages 215-225

Few pathologie phenomena, as shock, can originate from so many causes and involve so many complex physiologie mechanisms: The complexity of the phenomenon, thus, has resulted in extensive study and raised many uncertainties. Different conditions, such as hemorrhage, trauma, burns, bacterial infection, and anaphylaxis, can cause a shock state which initiates a chain of biochemical events that tends to maintain the shock. Recent progress in bio­ chemistry, physiology, and pharmacology has tended to clarify this chain of events, and elucidate the possible trigger mechanism. Besides the hormonal and catecholamine involvement, the possible intervention of various protease and lysosomal enzyme septems and kinin release introduces new elements into the characteristic mosaic of the shock state. This International Symposium, organized at Lake Corno by the Italian Society of Clinical Pharmacology and the International Society of Biochemical Pharmacology, is another in aseries of symposia under the joint auspices of the School of Pharmacy, State University of New York at Buffalo, and the Institute of Pharma­ cology, University of Milan, Italy. The Symposium has gathered together eminent scientists from such varied disciplines as surgery and pharmacology, internal medicine and biochemistry, physiology and pathology, all focusing on the question of shock. The many researchers in these specialities had the possibility of meeting and discussing together in a multidisciplinary fashion the many theories and experiences associated with this problem.

• Focusing
• biochemistry
• chemistry
• intervention
• pharmacology
• pharmacy
• physiology
• research
• trauma

• Institute of Pharmacology, University of Milan, Milan, Italy

  Aldo Bertelli

• Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, USA

  Nathan Back

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