Brain Chemistry and Mental Disease

1. Front Matter

   Pages i-xiii

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2. Enzymes: Implications in Mental Disease

   1. Introduction

      • A. Horita

      Pages 1-2

   2. Multiple Forms of Monoamine Oxidase in Developing Tissues: The Implications for Mental Disorder

      • Jean-Hung C. Shih, Samuel Eiduson

      Pages 3-20

   3. Regulation of Catecholamine Biosynthesis: Tyrosine Hydroxylase and Dihydropteridine Reductase

      • José M. Musacchio

      Pages 21-35

   4. Behavioral, Metabolic, and Enzymatic Studies of a Brain Indoleethylamine N-Methylating System

      • Arnold J. Mandell, Bruce Buckingham, David Segal

      Pages 37-60

   5. Transmethylation Processes in Schizophrenia

      • F. Antun, D. Eccleston, J. R. Smythies

      Pages 61-71

3. Psychoactive Agents: Biological Actions

   1. Effects of Drugs on Catecholamine Synthesis

      • Irwin J. Kopin

      Pages 73-82

   2. Pharmacological Implications of the Effects of Amphetamine and Its Analogs on the Turnover Rate of Tissue Catecholamines

      • E. Costa, M. K. Naimzada, A. Revuelta

      Pages 83-96

   3. Studies on the Mechanism of Action of 6-Methoxytetrahydro-β-Carboline in Elevating Brain Serotonin

      • Beng T. Ho, Dorothy Taylor, William M. McIsaac

      Pages 97-112

   4. Comparison of the Effects of Electrical Stimulation and Iontophoretic Dopamine on Neurons of the Nigro-Neostriatal Pathway

      • John D. Connor

      Pages 113-122

4. Biological Aspects of Affective Disorders

   1. Biogenic Amines and Affective Disorders

      • Alec Coppen

      Pages 123-133

   2. Catecholamines and Affective Illness: Studies with L-DOPA and Alpha-Methyl-Para-Tyrosine

      • Elliot S. Gershon, William E. Bunney Jr., Frederick K. Goodwin, Dennis L. Murphy, David L. Dunner, George M. Henry

      Pages 135-161

   3. Relationships between Stress and Brain 5-Hydroxytryptamine and Their Possible Significance in Affective Disorders

      • G. Curzon

      Pages 163-176

   4. Interactions between Adrenocortical Steroid Hormones, Electrolytes, and the Catecholamines

      • James W. Maas

      Pages 177-195

   5. Thyroid-Imipramine Interaction: Clinical Results and Basic Mechanism

      • Arthur J. Prange Jr., Ian C. Wilson, Angelina E. Knox, Thomas K. McClane, George R. Breese, Billy R. Martin et al.

      Pages 197-213

   6. Effects of Tricyclic Antidepressants on Norepinephrine Metabolism: Basic and Clinical Studies

      • Joseph J. Schildkraut, Paul R. Draskoczy, Elliot S. Gershon, Peter Reich, Edwin L. Grab

      Pages 215-236

5. Brain Amines and Affective Disorders

   1. Overview

      • Seymour Kety

      Pages 237-244

   2. Discussion

      • Beng T. Ho, William M. McIsaac

      Pages 245-263

6. Genetic and Metabolic Factors in Mental Disorders

   1. Heterogeneous Distributions of Schizophrenia

      • George Wilson McBee

      Pages 265-274

   2. Frequency of Genetic Polymorphism: Implications for Mental Disease

      • Charles R. Shaw

      Pages 275-280

This volume contains the proceedings of the fourth international symposium held in November 1970 at the Texas Research Institute of Mental Sciences in Houston. Leading psychiatrists, biochemists, and pharmacologists from the United States and Great Britain presented new material and reviewed current concepts concerning schizophrenia and the affective disorders, with particular reference to the neurochemical basis of the etiology and chemotherapy of these diseases. Although the multiple mechanisms of mental disease are still not fully understood, substantial progress has definitely been made. The greatest contribution has come through the development of new therapeutic agents that not only provide invaluable help to the mentally ill but serve as chemical tools for studying the biological mechanisms associated with the disease state. Studies concerning the proposed catecholamine and indolealkylamine hypotheses for affective disorders and the possible formation of endogenous. toxins in schizophrenia have stimulated significant new research. This book presents new studies of schizophrenia and the affective disorders in one volume. It is our hope that it represents an effective integration of basic biochemical and pharmacological research with current clinical findings and that it will increase understanding of the etiology of mental disease and provide an impetus for the development of more effective therapeutic agents. We thank Drs. Gordon Farrell, Samuel Gershon, A. Horita, Irwin Kopin, and Joseph Schildkraut for their help with the organization of the meeting and for chairing the corresponding sessions.

• brain
• catecholamines
• depression
• neurons
• organization
• research
• schizophrenia
• toxin

• Texas Research Institute of Mental Sciences, Texas Medical Center, Houston, USA

  Beng T. Ho, William M. McIsaac

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