Contemporary Topics in Immunobiology

1. Front Matter

   Pages i-xiii

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2. Comparative Immunology of Carcinogenesis by DNA Viruses

   • Satvir S. Tevethia, Fred Rapp

   Pages 1-69

3. Immunity to Leukemia, Lymphoma, and Fibrosarcoma in Cats: A Case for Immunosurveillance

   • M. Essex

   Pages 71-106

4. Intracellular and Systemic Regulation of Biologically Distinguishable Endogenous Type C RNA Viruses of Mouse Cells

   • Stuart A. Aaronson, John R. Stephenson

   Pages 107-126

5. Mammalian C-Type Oncornaviruses: Relationships between Viral Structural and Cell-Surface Antigens and Their Possible Significance in Immunological Defense Mechanisms

   • Werner Schäfer, Dani P. Bolognesi

   Pages 127-167

6. Natural Immunity to Endogenous Oncornaviruses in Mice

   • James N. Ihle, M. G. Hanna Jr.

   Pages 169-194

7. Biological and Structural Pleomorphism of the Oncornavirus Envelope Glycoprotein, gp70

   • Bert C. Del Villano, Stephen J. Kennel, Richard A. Lerner

   Pages 195-207

8. Autoimmunity, Oncornaviruses, and Lymphomagenesis

   • Martin S. Hirsch, Max R. Proffitt, Paul H. Black

   Pages 209-227

9. Natural Immunity to Murine Mammary Tumor Viruses

   • P. Bentvelzen, P. C. Creemers

   Pages 229-238

10. Immunogenicity and MuMTV-like Antigenicity of Human Breast Cancer Tissues

    • Maurice M. Black

    Pages 239-262

11. Clinical Implications of Immunity to Oncogenic Viruses

    • Paul H. Levine

    Pages 263-286

12. Back Matter

    Pages 287-289

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It has long been suspected, and recently confirmed, that there is an etiologic relationship between several viruses and naturally occurring neoplasias. Virus precursors in the form of nucleic acids or antigens have consistently been associated with certain neoplasias. However, the role of these virus-specified precursors in etiology remains obscure. Recent studies of virus-associated neo­ plasias have led to advances in molecular techniques, which have yielded increas­ ingly sensitive assays for detection of virus-specific nucleic acids, and which have enabled the disruption of virus particles without concomitant loss in antigenicity of the components. These procedures have, in turn, resulted in molecular probes that allow more definitive evaluation of the host response to its virus and to the tumor cell with which the virus or its precursors are associated. Evaluations of the immune response and status of the host have provided important informa­ tion about carcinogenesis and the tools for seroepidemiological studies of a variety of cancers. These seroepidemiological studies have demonstrated that several human cancers, e. g. , Burkitt's lymphoma and nasopharyngeal carcinoma, are probably virus-induced, and that antibodies that are diagnostic and prog­ nostic for these diseases are detectable. The conclusion that feline leukemia is a disease transmitted horizontally by a virus resulted primarily from immunologi­ cal experiments.

• antibody
• antigen
• diseases
• immune response
• immunobiology
• leukemia
• virus

• Basic Research Program, NCI Frederick Cancer Research Center, Frederick, USA

  Michael G. Hanna

• Department of Microbiology and Specialized Cancer Research Center The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, USA

  Fred Rapp

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