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Molecular Mechanisms for Repair of DNA

Part A

  • Book
  • © 1975

Overview

Editors:
  1. Philip C. Hanawalt

    1. Department of Biology, Stanford University, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Richard B. Setlow

    1. Biology Department, Brookhaven National Laboratory, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Basic Life Sciences (BLSC, volume 5)

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Table of contents (56 chapters)

  1. Front Matter

    Pages i-xxiv
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  2. Repairable Damage in DNA

    1. Front Matter

      Pages 1-1
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    2. Repairable Damage in DNA: Overview

      • Peter A. Cerutti
      Pages 3-12

    3. The Nature of the Alkylation Lesion in Mammalian Cells

      • B. Strauss, D. Scudiero, E. Henderson
      Pages 13-24

    4. “Excision” of Bases from DNA Methylated by Carcinogens in Vivo and Its Possible Significance in Mutagenesis and Carcinogenesis

      • P. D. Lawley
      Pages 25-28

    5. Alkali-Labile Lesions in DNA from Cells Treated with Methylating Agents, 4-Nitroquinoline-N-oxide, or Ultraviolet Light

      • I. G. Walker, R. Sridhar
      Pages 29-30

    6. Apurinic and Apyrimidinic Sites in DNA

      • Tomas Lindahl, Siv Ljungquist
      Pages 31-38

    7. Maintenance of DNA and Repair of Apurinic Sites

      • Walter G. Verly
      Pages 39-46

    8. DNA Turnover and Strand Breaks in Escherichia coli

      • Philip Hanawalt, Anthony Grivell, Hiroaki Nakayama
      Pages 47-50

    9. Excision-Repair of γ-Ray-Damaged Thymine in Bacterial and Mammalian Systems

      • P. V. Hariharan, J. F. Remsen, P. A. Cerutti
      Pages 51-59

    10. Formation of Dimers in Ultraviolet-Irradiated DNA

      • Clifford Brunk
      Pages 61-65

    11. An Enzymatic Assay for Pyrimidine Dimers in DNA

      • Ann Ganesan
      Pages 67-69

  3. Enzymatic Photoreactivation

    1. Front Matter

      Pages 71-71
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    2. Enzymatic Photoreactivation: Overview

      • Claud S. Rupert
      Pages 73-87

    3. Kinetics of Photoreactivation

      • Walter Harm
      Pages 89-101

    4. Purifying the Escherichia coli Photoreactivating Enzyme

      • Betsy M. Sutherland
      Pages 103-106

    5. The Human Leukocyte Photoreactivating Enzyme

      • Betsy M. Sutherland
      Pages 107-113

    6. Photorepair of RNA

      • Milton P. Gordon
      Pages 115-121

  4. Dark Repair in Bacteriophage Systems

    1. Front Matter

      Pages 123-123
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    2. Dark Repair in Bacteriophage Systems: Overview

      • Errol C. Friedberg
      Pages 125-133
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Keywords

About this book

An "age" has passed in the 40 years since we first observed recovery from radiation damage in irradiated bacteria. During the early 1930s, we had been discussing the possibility of rapid changes after radiation exposure with Farring­ ton Daniels, Benjamin Duggar, John Curtis, and others at the University of Wisconsin. After working with living cells, we had concluded that organisms receiving massive insults must have a wide variety of repair mechanisms available for restoration of at least some of the essential properties of the cell. The problem was how to fmd and identify these recovery phenomena. At that time I was working on a problem considered to be of great importance-the existence of the so-called mitogenetic rays. Several hundred articles and a score of books had already appeared dealing with mitogenetic rays, a type of radiation that was thought to exist in the shorter ultraviolet region. Our search for mitogenetic rays necessitated the design of experiments of greatest sensitivity for the detection of ultraviolet. It was vital that conditions be kept as constant as possible during exposure. All the work was done at icewater temperature (3-5°C) during and after exposure. We knew that light was an important factor for cell recovery, so all our experiments were done in dim light, with the plated-out cells being covered with dark cloth. Our statements on the effect of visible light stimulated Kelner to search for "photoreactivation' (as it was later called).

Editors and Affiliations

  • Department of Biology, Stanford University, USA

    Philip C. Hanawalt

  • Biology Department, Brookhaven National Laboratory, USA

    Richard B. Setlow

Bibliographic Information

  • Book Title: Molecular Mechanisms for Repair of DNA

  • Book Subtitle: Part A

  • Editors: Philip C. Hanawalt, Richard B. Setlow

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4684-2895-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1975

  • Softcover ISBN: 978-1-4684-2897-1Published: 27 December 2012

  • eBook ISBN: 978-1-4684-2895-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXIV, 418

  • Topics: Animal Anatomy / Morphology / Histology

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