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Biomedical Applications of Immobilized Enzymes and Proteins

Volume 1

  • Book
  • © 1977

Overview

Editors:
  1. Thomas Ming Swi Chang

    1. Medical Research Council of Canada, Artificial Organs Research Unit, McGill University, Montreal, Canada

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xx
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  2. Introduction

    1. Introduction

      • T. M. S. Chang
      Pages 1-4

  4. Experimental Applications in Therapy

    1. Front Matter

      Pages 91-91
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    2. Rationale and Strategies for the Therapeutic Applications of Immobilized Enzymes

      • T. M. S. Chang
      Pages 93-104

    3. l-Asparaginase as a Model for Enzyme Therapy of Substrate-Dependent Tumors

      • E. D. Siu Chong, T. M. S. Chang
      Pages 105-120

    4. A Biomedical View of Enzyme Replacement Strategies in Genetic Disease

      • Charles R. Scriver
      Pages 121-146

    5. Experimental Therapy Using Semipermeable Microcapsules Containing Enzymes and Other Biologically Active Material

      • T. M. S. Chang
      Pages 147-162

    6. Stabilized Urease Microencapsulated

      • David L. Gardner, Donald C. Emmerling
      Pages 163-170

    7. Liquid-Membrane-Encapsulated Enzymes

      • Sheldon W. May, Norman N. Li
      Pages 171-190

    8. Liposomes as Carriers of Enzymes and Proteins in Medicine

      • Gregory Gregoriadis
      Pages 191-218

    9. Enzyme-Loaded Erythrocytes

      • Garret Ihler, Robert Glew
      Pages 219-226

    10. Enzyme Entrapment in Erythrocytes and Liposomes for the Treatment of Lysosomal Storage Diseases

      • R. J. Desnick, Morris B. Fiddler, Suzanne R. Thorpe, Lynn D. Steger
      Pages 227-244

    11. Strategy for Enzyme Therapy: Immobilization in Hypoallergenic Gel Versus Entrapment in Red Blood Cell

      • Stuart Updike
      Pages 245-255
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Keywords

About this book

I) ADSORPTION EEEEEEEE E E carrier 2) COVALENT LINKAGE a) Insoluble support b) Intermolecular linkage N'E~ ~~ c) Soluble support 0 \:)....m 3) tM TRIX (MOLECULAR) ENTRAPMENT ~~~~~;;..,J~-polymer matrix 4) ENCAPSULATION membrane FIGURE I. Classification of immobilized enzymes. Covalently linked, adsorbed, and matrix-entrapped enzymes represent stage II, research on the microenvironment. Microencapsulation represents stage III, research on the intracellular environment. Further subdivision of microencapsulated enzymes will be found in Chapter 12. 4 T. M. S. CHANG matrix entrapment. In this section, detailed discussions will center on clinical analysis, urine analysis, monitoring of environmental pollution, radioimmune assay, enzyme-linked immunosorbent assay, enzyme electrodes, and other approaches involving immobilized enzymes, antibodies, and antigens. In the final section, research workers describe and discuss the perspectives of immobilized enzymes and proteins. Here, they speculate on the future potential of possible approaches, even though these may not have been extensively studied or tested at the laboratory stage. The biomedical applications of enzymes and proteins, especially in the thera­ peutic area, is in a very early stage of development. Much remains to be explored and studied, and the area is wide open for investigators interested in original research in a new interdisciplinary area. References Chang, T. M. S., 1972, Artificial Cells, Charles C. Thomas, Publisher, Springfield, Ill. Dunlop, R. B. (ed.), 1974, Immobilized Biochemicals and Affinity ChrOTIULtography, Plenum Press, N ew York.

Editors and Affiliations

  • Medical Research Council of Canada, Artificial Organs Research Unit, McGill University, Montreal, Canada

    Thomas Ming Swi Chang

Bibliographic Information

  • Book Title: Biomedical Applications of Immobilized Enzymes and Proteins

  • Book Subtitle: Volume 1

  • Editors: Thomas Ming Swi Chang

  • DOI: https://doi.org/10.1007/978-1-4684-2610-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1977

  • Softcover ISBN: 978-1-4684-2612-0Published: 30 March 2012

  • eBook ISBN: 978-1-4684-2610-6Published: 21 November 2013

  • Edition Number: 1

  • Number of Pages: XX, 448

  • Number of Illustrations: 58 b/w illustrations

  • Topics: Biomedical Engineering and Bioengineering

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