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Pharmacology and Pharmacokinetics

  • Book
  • © 1974

Overview

Editors:
  1. Torsten Teorell

    1. Institute of Physiology and Medical Biophysics, University of Uppsala, Uppsala, Sweden
      Fogarty International Center, National Institutes of Health, Bethesda, USA

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  2. Robert L. Dedrick

    1. Biomedical Engineering and Instrumentation Branch Division of Research Services, National Institutes of Health, Bethesda, USA

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  3. Peter G. Condliffe

    1. Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism, and Digestive Diseases National Institutes of Health, Bethesda, USA

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Introduction

    • G. Segre
    Pages 1-1

  3. Classical Pharmacokinetics to the Frontier

    • Edward R. Garrett
    Pages 3-25

  4. A Modern View of Pharmacokinetics

    • John G. Wagner
    Pages 27-68

  5. Translation of Pharmacokinetics to Clinical Medicine

    • L. Dettli
    Pages 69-85

  6. Effect of Route of Administration on Drug Disposition

    • S. Riegelman, M. Rowland
    Pages 87-103

  7. Interspecies Scaling

    • R. T. Williams
    Pages 105-115

  8. Animal Scale-Up

    • Robert L. Dedrick
    Pages 117-145

  9. Drug Metabolism in Normal and Disease States

    • A. H. Conney, B. Craver, R. Kuntzman, E. J. Pantuck
    Pages 147-162

  10. Drug Action: Target Tissue, Dose-Response Relationships, and Receptors

    • E. J. Ariëns, A. M. Simonis
    Pages 163-189

  11. Pharmacokinetics and Pharmacodynamics of Acetazolamide in Relation to its Use in the Treatment of Glaucoma

    • Per J. Wistrand
    Pages 191-194

  12. The Role of the Lungs in the Metabolism of Vasoactive Substances

    • John R. Vane
    Pages 195-207

  13. The Importance of Tissue Distribution in Pharmacokinetics

    • James R. Gillette
    Pages 209-231

  14. Physiological and Physical Factors Governing the Initial Stages of Drug Distribution

    • Seymour S. Kety
    Pages 233-240

  15. Target Organ Modification in Pharmacology: Reversible Osmotic Opening of the Blood-Brain Barrier by Opening of Tight Junctions

    • Stanley I. Rapoport
    Pages 241-251

  16. Pharmacogenetics: Single Gene Effects

    • Bert N. La Du
    Pages 253-260

  17. Application of Pharmacokinetic Principles to the Elucidation of Polygenically Controlled Differences in Drug Response

    • Elliot S. Vesell
    Pages 261-280

  18. Immediate Immunologic Reactions: Noncytolytic Mediator Release and Cytolytic Cell Destruction

    • Edward J. Goetzl, Shaun Ruddy, Daniel J. Stechschulte, K. Frank Austen
    Pages 281-296

  19. Pharmacokinetic Studies with Amphetamines: Relationship to Neuropsychiatric Disorders

    • Lars-M. Gunne, Erik Änggård
    Pages 297-313

  20. A Pharmacokinetic Approach to the Treatment of Depression

    • Folke Sjöqvist
    Pages 315-320
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Keywords

About this book

This collection of papers by leading pharmacokineticists and pharmacolo­ gists is the proceedings of a conference held at the John E. · Fogarty International Center for Advanced Study in the Health Sciences, National Institutes of Health, October 30 to November 1, 1972. As part of its advanced study program, the Center conducts workshops, seminars, and conferences on topics related to the biomedical interests of the Scholars-in­ Residence. Professor Torsten Teorell came to the Center in 1970 as one of the first Scholars. In 1971 and 1972, he spent several months at the Center devoting his attention to contemporary problems in the application of pharmacoki­ netics to experimental and clinical pharmacology. As one of the founders of pharmacokinetics, Professor Teorell has made many contributions to the field since he first presented a formal multicompartment model for the analysis of drug action and drug metabolism in 1937 (Teorell, 1937). Since the appearance of his original paper, pharmacodynamics, or pharmacoki­ netics, has become increasingly important as a tool for the study of drug action in patients. The translation of experimental pharmacological findings into therapeutic regimens is today increasingly dependent on ade qua te models of drug action. The purpose of the conference, of which this book is the proceedings, was to discuss contemporary findings in this important biomedical research field. The conference program was designed by Professor Teorell with the help of a small committee which included Drs. Edward R.

Editors and Affiliations

  • Institute of Physiology and Medical Biophysics, University of Uppsala, Uppsala, Sweden

    Torsten Teorell

  • Fogarty International Center, National Institutes of Health, Bethesda, USA

    Torsten Teorell

  • Biomedical Engineering and Instrumentation Branch Division of Research Services, National Institutes of Health, Bethesda, USA

    Robert L. Dedrick

  • Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism, and Digestive Diseases National Institutes of Health, Bethesda, USA

    Peter G. Condliffe

Bibliographic Information

  • Book Title: Pharmacology and Pharmacokinetics

  • Editors: Torsten Teorell, Robert L. Dedrick, Peter G. Condliffe

  • DOI: https://doi.org/10.1007/978-1-4684-2055-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1974

  • Softcover ISBN: 978-1-4684-2057-9Published: 12 June 2012

  • eBook ISBN: 978-1-4684-2055-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 388

  • Topics: Pharmacology/Toxicology

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