Mechanisms in Fibre Carcinogenesis

1. Front Matter

   Pages i-xiii

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2. The Carcinogenicity of Mineral Fibres

   1. Front Matter

      Pages 1-1

      PDF

   2. Human studies

      1. Gaps in Knowledge of Fibre Carcinogenesis: An Epidemiologist’s View

         • Douglas Liddell

         Pages 3-15

      2. Health Effects of Insulation Wools (Rock/Slag Wool and Glass Wool) and Future Research Needs

         • David Douglas

         Pages 17-27

      3. Non-Asbestos Fibre Burden in Individuals Exposed to Asbestos

         • R. F. Dodson, M. G. Williams Jr., C. J. Corn, A. Brollo, C. Bianchi

         Pages 29-37

      4. Influence of Long-Lasting Asbestos Exposure on Immunological Status of Asbestos Exposed Shipyard Workers

         • I. Trosic, M. Saric, Z. Pisl, L. Stilinovic

         Pages 39-42

   3. Animal studies

      1. Mesotheliomas in Man and Experimental Animals

         • J. C. Wagner

         Pages 45-49

      2. Experimental Studies on Mineral Fibre Carcinogenesis: An Overview

         • J. M. G. Davis

         Pages 51-58

      3. The Relevance of Animal Bioassays to Assess Human Health Hazards to Inorganic Fibrous Materials

         • Neil F. Johnson

         Pages 59-69

      4. Relative Intrinsic Potency of Asbestos and Erionite Fibers: Proposed Mechanism of Action

         • David L. Coffin, Andrew J. Ghio

         Pages 71-80

      5. Histopathological Analysis of Tumour Types after Intraperitoneal Injection of Mineral Fibres in Rats

         • S. Rittinghausen, H. Ernst, H. Muhle, R. Fuhst, U. Mohr

         Pages 81-89

      6. Radiation-Induced Mesotheliomas in Rats

         • F. F. Hahn, P. J. Haley, A. F. Hubbs, M. D. Hoover, D. L. Lundgren

         Pages 91-99

3. Chemical and Physical Properties

   1. Front Matter

      Pages 101-101

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   2. Fibre Size and Chemistry

      1. Carcinogenic Effect Related to the Fiber Physics and Chemistry

         • K. R. Spurny

         Pages 103-113

      2. Fibre Size and Chemistry Effects <i>in Vitro</i> and <i>in Vivo</i> Compared

         • R. C. Brown, J. A. Hoskins, E. A. Sara, C. E. Evans, K. J. Cole

         Pages 115-120

      3. Inflammation and Immunomodulation Caused by Short and Long Amosite Asbestos Samples

         • K. Donaldson, S. Szymaniec, X. Y. Li, D. M. Brown, G. M. Brown

         Pages 121-130

      4. Fiber Dimensions and Mesothelioma: A Reappraisal of the Stanton Hypothesis

         • Agnes B. Kane

         Pages 131-141

      5. Acute Pulmonary Effects of Inhaled Wollastonite Fibers are Dependent on Fiber Dimensions and Aerosol Concentrations

         • David B. Warheit, Kimberly A. Moore, Michael C. Carakostas, Mark A. Hartsky

         Pages 143-156

      6. Toxicological Aspects of the Pathogenesis of Fiber-Induced Pulmonary Effects

         • G. Oberdörster, B. E. Lehnert

         Pages 157-179

      7. Durability of Various Mineral Fibres in Rat Lungs

         • H. Muhle, B. Bellmann, F. Pott

         Pages 181-187

The Editors are sorry that the production of this volume was delayed by the ill­ health of one of them and we hope that this does not detract from the value of the con­ tents. For once this delay is not the fault of any of the authors only the editors are to blame. Many of the workers in the field of fibre toxicology became convinced by the middle 1980's that the worst of the furore over asbestos was over although we were left with an intriguing problem - how does asbestos cause disease? It was expected that the future impact of fibres on human health would be very small since asbestos exposure would be controlled and there was little chance that man-made fibres would prove haz­ ardous. These man-made fibres are much thicker than asbestos and, in most cases, they are less durable in the body. Both of these properties are believed to make them much less likely to cause disease. However many of us had fallen into the habit of calling these materials "asbestos substitutes" and thus they have acquired a little of the notoriety at­ tached to the natural fibrous minerals. Very few of these man-made fibres are actually used as replacements for asbestos. Asbestos was not suitable for the uses to which the insulation wools are usually put and the ceramic fibres are replacements for fire brick not asbestos which is destroyed at the temperatures at which these materials are used.

• Pathogene
• carcinogenesis
• cell
• gene expression
• mesothelioma
• pathogenesis
• toxicity
• toxicology

• Medical Research Council Toxicology Unit, Carshalton, Surrey, UK

  Robert C. Brown, John A. Hoskins

• Inhalation Toxicology Research Institute, Albuquerque, USA

  Neil F. Johnson

Policies and ethics