Insecticide Action

1. Front Matter

   Pages i-viii

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2. Insecticide Actions on Gaba Receptors and Voltage-Dependent Chloride Channels

   • Mohyee E. Eldefrawi, Amira T. Eldefrawi

   Pages 1-11

3. Antagonism of Insect Muscle Glutamate Receptors — with Particular Reference to Arthropod Toxins

   • Peter N. R. Usherwood, Ian S. Blagbrough

   Pages 13-31

4. Molecular Interactions of Organophosphates (OPs), Oximes and Carbamates at Nicotinic Receptors

   • Edson X. Albuquerque, Manickavasagom Alkondon, Sharad S. Deshpande, Vanga K. Reddy, Yasco Aracava

   Pages 33-53

5. The Role of Ion Channels in Insecticide Action

   • Toshio Narahashi

   Pages 55-84

6. Pharmacological Characterization of Insecticide-Binding Domains of the Voltage-Sensitive Sodium Channel

   • David M. Soderlund, Jeffrey R. Bloomquist, Gregory T. Payne, James A. Ottea

   Pages 85-97

7. Drosophila Sodium Channel Mutations Affect Pyrethroid Sensitivity

   • Linda M. Hall, Durgadas P. Kasbekar

   Pages 99-114

8. Actions of Insecticides in Mammalian Central Nervous System — Use of in Vivo Hippocampal Evoked Potentials

   • T. E. Albertson, R. M. Joy

   Pages 115-137

9. Enhanced Neurotransmitter Release by Pyrethroid Insecticides

   • J. Marshall Clark, Jacques R. Marion

   Pages 139-168

10. Mechanism of Action of the Cytolytic Toxin of Bacillus thuringiensis israelensis

    • Sarjeet S. Gill, Edward Chow, Gur Jai Pal Singh, Patricia Pietrantonio, Shu-Mai Dai, Liu Shi et al.

    Pages 169-188

11. Synaptic Toxins from Arachnid Venoms: Probes for New Insecticide Targets

    • Michael E. Adams, Vytautas P. Bindokas, Eliahu Zlotkin

    Pages 189-203

12. Studies on the Molecular Pathogenesis of Organophosphorus Compound-Induced Delayed Neurotoxicity (OPIDN)

    • Mohamed B. Abou-Donia, Daniel M. Lapadula

    Pages 205-216

13. Physiological Compensation for Toxic Actions of Organophosphate Insecticides

    • Janice E. Chambers, Howard W. Chambers

    Pages 217-232

14. Monooxygenations: Interactions and Expression of Toxicity

    • Patricia E. Levi, Ernest Hodgson

    Pages 233-244

15. Non-Catalytic Detoxication of Acetylcholinesterase Inhibitors by Liver and Plasma Proteins

    • Howard W. Chambers, Janice E. Chambers

    Pages 245-251

16. Use of Resistance Phenomena as a Research Tool for Studying the Mechanisms of Action of Insecticides

    • Fumio Matsumura

    Pages 253-266

17. Back Matter

    Pages 267-275

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Intoxication of humans and animals has become increasingly important in recent years as has contamination of the environment by a variety of chemicals. In order to develop effective means by which such intoxication and contamination can be properly handled, it is imperative to know how these environmental agents act in humans and animals. Despite studies conducted by various investigators, the mechanisms of action of these environmental agents have not been fully elucidated. Insecticides are by no means an exception in terms of the seriousness of the problem and of the urgency of the need for such information. In order to complete a picture of the effects of any particular insecticide, it is of utmost importance that its actions at various levels ranging from those of molecules to whole animals be analyzed and synthesized. To understand the toxicological action on animals or humans, it is not sufficient to know the action at each level only. The actions at various levels must be integrated to construct a picture of the toxic effect on the intact organism. However, in spite of the large body of information that has been accumulated during the past few decades, little or no attempt has been made to integrate experimental data obtained at the molecular, cellular, organ, and animal levels together in order to define the whole picture of insecticidal action.

• GABA
• Glutamat
• Mammalia
• Nicotin
• animals
• insects
• mutation
• nervous system
• pharmacology
• phosphorus
• protein
• receptor
• research
• system
• toxicity

• Northwestern University Medical School, Chicago, USA

  Toshio Narahashi

• Mississippi State University, Mississippi State, USA

  Janice E. Chambers

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